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Sodium in PDB 6qds: Crystal Structure of 14-3-3SIGMA in Complex with A PAK6 PT99 Phosphopeptide Stabilized By Semi-Synthetic Fusicoccane Fc-Ncpc

Enzymatic activity of Crystal Structure of 14-3-3SIGMA in Complex with A PAK6 PT99 Phosphopeptide Stabilized By Semi-Synthetic Fusicoccane Fc-Ncpc

All present enzymatic activity of Crystal Structure of 14-3-3SIGMA in Complex with A PAK6 PT99 Phosphopeptide Stabilized By Semi-Synthetic Fusicoccane Fc-Ncpc:
2.7.11.1;

Protein crystallography data

The structure of Crystal Structure of 14-3-3SIGMA in Complex with A PAK6 PT99 Phosphopeptide Stabilized By Semi-Synthetic Fusicoccane Fc-Ncpc, PDB code: 6qds was solved by S.A.Andrei, A.Kaplan, A.E.Fournier, C.Ottman, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.52 / 1.72
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 82.420, 111.770, 62.620, 90.00, 90.00, 90.00
R / Rfree (%) 16.8 / 19.8

Other elements in 6qds:

The structure of Crystal Structure of 14-3-3SIGMA in Complex with A PAK6 PT99 Phosphopeptide Stabilized By Semi-Synthetic Fusicoccane Fc-Ncpc also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure of 14-3-3SIGMA in Complex with A PAK6 PT99 Phosphopeptide Stabilized By Semi-Synthetic Fusicoccane Fc-Ncpc (pdb code 6qds). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Crystal Structure of 14-3-3SIGMA in Complex with A PAK6 PT99 Phosphopeptide Stabilized By Semi-Synthetic Fusicoccane Fc-Ncpc, PDB code: 6qds:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in 6qds

Go back to Sodium Binding Sites List in 6qds
Sodium binding site 1 out of 2 in the Crystal Structure of 14-3-3SIGMA in Complex with A PAK6 PT99 Phosphopeptide Stabilized By Semi-Synthetic Fusicoccane Fc-Ncpc


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of 14-3-3SIGMA in Complex with A PAK6 PT99 Phosphopeptide Stabilized By Semi-Synthetic Fusicoccane Fc-Ncpc within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na303

b:41.8
occ:0.97
 O A:LYS77 2.3 71.7 1.0
OE1 A:GLU80 2.6 15.6 1.0
O A:HOH530 2.9 24.8 1.0
OE2 A:GLU80 3.0 17.5 1.0
CD A:GLU80 3.0 13.0 1.0
HA3 A:GLY78 3.2 45.7 1.0
C A:LYS77 3.4 62.5 1.0
CA A:GLY78 4.0 38.1 1.0
N A:GLY78 4.1 45.1 1.0
HD2 A:PRO79 4.1 22.0 1.0
HB3 A:LYS77 4.2 70.2 1.0
HA A:LYS77 4.3 67.8 1.0
CG A:GLU80 4.4 12.3 1.0
CA A:LYS77 4.4 56.5 1.0
HB2 A:GLU80 4.4 14.3 1.0
HG2 A:GLU80 4.5 14.5 1.0
H A:GLU80 4.6 15.1 1.0
HA2 A:GLY78 4.7 45.7 1.0
C A:GLY78 4.8 23.4 1.0
CB A:LYS77 4.8 58.5 1.0
CB A:GLU80 5.0 12.1 1.0
H A:GLY78 5.0 54.1 1.0
CD A:PRO79 5.0 18.5 1.0

Sodium binding site 2 out of 2 in 6qds

Go back to Sodium Binding Sites List in 6qds
Sodium binding site 2 out of 2 in the Crystal Structure of 14-3-3SIGMA in Complex with A PAK6 PT99 Phosphopeptide Stabilized By Semi-Synthetic Fusicoccane Fc-Ncpc


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Crystal Structure of 14-3-3SIGMA in Complex with A PAK6 PT99 Phosphopeptide Stabilized By Semi-Synthetic Fusicoccane Fc-Ncpc within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na304

b:33.1
occ:0.76
 O A:HOH680 2.2 54.3 1.0
O A:HOH432 2.3 2.0 0.5
O A:HOH598 2.5 15.2 1.0
OE1 A:GLU2 2.8 15.6 1.0
H A:ARG3 3.7 8.6 1.0
HB3 A:ARG3 3.7 8.6 1.0
O A:HOH726 3.9 16.8 1.0
CD A:GLU2 4.0 15.9 1.0
HB3 A:GLU2 4.3 10.6 1.0
HB2 A:ARG3 4.3 8.6 1.0
H A:ALA4 4.4 10.2 1.0
N A:ARG3 4.4 7.3 1.0
O A:HOH708 4.4 41.9 1.0
CB A:ARG3 4.4 7.3 1.0
O A:HOH462 4.5 11.9 1.0
HA A:GLU2 4.5 15.9 1.0
OE2 A:GLU2 4.5 16.6 1.0
O A:HOH450 4.7 24.2 1.0
CB A:GLU2 4.9 8.8 1.0

Reference:

A.Kaplan, S.A.Andrei, C.Ottmann, A.E.Fournier. A Single-Agent Polypharmacological Approach to Stimulate Axon Regeneration To Be Published.
Page generated: Tue Oct 8 12:53:20 2024

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