Sodium in PDB 6hr8: Hmg-Coa Reductase From Methanothermococcus Thermolithotrophicus in Complex with Nadph at 2.9 A Resolution

All present enzymatic activity of Hmg-Coa Reductase From Methanothermococcus Thermolithotrophicus in Complex with Nadph at 2.9 A Resolution:
1.1.1.34;

The structure of Hmg-Coa Reductase From Methanothermococcus Thermolithotrophicus in Complex with Nadph at 2.9 A Resolution, PDB code: 6hr8 was solved by T.Wagner, B.Voegeli, T.J.Erb, S.Shima, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	24.99 / 2.90
Space group	P 4 21 2
Cell size a, b, c (Å), α, β, γ (°)	231.790, 231.790, 98.714, 90.00, 90.00, 90.00
R / Rfree (%)	21.1 / 24.3

The binding sites of Sodium atom in the Hmg-Coa Reductase From Methanothermococcus Thermolithotrophicus in Complex with Nadph at 2.9 A Resolution (pdb code 6hr8). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Hmg-Coa Reductase From Methanothermococcus Thermolithotrophicus in Complex with Nadph at 2.9 A Resolution, PDB code: 6hr8:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Hmg-Coa Reductase From Methanothermococcus Thermolithotrophicus in Complex with Nadph at 2.9 A Resolution


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Hmg-Coa Reductase From Methanothermococcus Thermolithotrophicus in Complex with Nadph at 2.9 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ D:Na503 b:81.4 occ:1.00 O D:CYS118 2.9 98.6 1.0 OE2 D:GLU261 3.2 91.9 1.0 OE1 D:GLU261 3.5 89.6 1.0 C D:CYS118 3.7 98.8 1.0 CD D:GLU261 3.7 90.7 1.0 CE D:LYS258 3.8 0.9 1.0 O D:PHE256 4.1 75.2 1.0 CA D:CYS118 4.2 0.8 1.0 CG D:LYS258 4.3 0.8 1.0 CB D:CYS118 4.4 0.5 1.0 CD D:LYS258 4.7 0.3 1.0 N D:GLY119 4.7 97.6 1.0 NZ D:LYS258 4.8 0.5 1.0 CA D:GLY119 5.0 95.6 1.0

Sodium binding site 2 out of 2 in the Hmg-Coa Reductase From Methanothermococcus Thermolithotrophicus in Complex with Nadph at 2.9 A Resolution


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Hmg-Coa Reductase From Methanothermococcus Thermolithotrophicus in Complex with Nadph at 2.9 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ D:Na504 b:0.5 occ:1.00 OE2 D:GLU28 2.5 0.9 1.0 CD D:GLU28 3.6 0.2 1.0 CG D:GLU28 4.0 0.2 1.0 O D:ASP23 4.5 0.2 1.0 OE1 D:GLU28 4.7 0.5 1.0 CB D:ASP23 4.9 0.9 1.0

B.Vogeli, S.Shima, T.J.Erb, T.Wagner. Crystal Structure of Archaeal Hmg-Coa Reductase: Insights Into Structural Changes of the C-Terminal Helix of the Class-I Enzyme. Febs Lett. V. 593 543 2019.
ISSN: ISSN 0014-5793
PubMed: 30702149
DOI: 10.1002/1873-3468.13331