Sodium in PDB 6fgb: Human Fcrn Extra-Cellular Domain Complexed with Fab Fragment of Rozanolixizumab

The structure of Human Fcrn Extra-Cellular Domain Complexed with Fab Fragment of Rozanolixizumab, PDB code: 6fgb was solved by K.Sarkar, T.Ceska, C.Meier, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 2.90
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	150.100, 150.100, 89.150, 90.00, 90.00, 120.00
R / Rfree (%)	23.2 / 28.4

The structure of Human Fcrn Extra-Cellular Domain Complexed with Fab Fragment of Rozanolixizumab also contains other interesting chemical elements:

Chlorine

(Cl)

2 atoms

The binding sites of Sodium atom in the Human Fcrn Extra-Cellular Domain Complexed with Fab Fragment of Rozanolixizumab (pdb code 6fgb). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Human Fcrn Extra-Cellular Domain Complexed with Fab Fragment of Rozanolixizumab, PDB code: 6fgb:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Human Fcrn Extra-Cellular Domain Complexed with Fab Fragment of Rozanolixizumab


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Human Fcrn Extra-Cellular Domain Complexed with Fab Fragment of Rozanolixizumab within 5.0Å range: probe atom residue distance (Å) B Occ A:Na402 b:46.9 occ:1.00 OE1 A:GLU151 2.4 46.0 1.0 CD A:GLU151 3.6 45.1 1.0 CZ A:PHE110 3.8 29.8 1.0 CE2 A:PHE110 4.1 31.1 1.0 CZ3 A:TRP141 4.1 53.3 1.0 OE2 A:GLU151 4.2 44.6 1.0 NE1 A:TRP127 4.3 38.0 1.0 CE1 A:PHE75 4.3 40.1 1.0 CD2 A:LEU94 4.4 38.3 1.0 CD1 A:LEU74 4.4 44.1 1.0 CG A:LYS71 4.4 43.1 1.0 CH2 A:TRP141 4.4 53.1 1.0 CZ2 A:TRP127 4.5 38.0 1.0 CE3 A:TRP141 4.5 53.1 1.0 NZ A:LYS71 4.6 42.2 1.0 CG A:GLU151 4.8 43.2 1.0 CE2 A:TRP127 4.8 37.7 1.0 CE1 A:PHE110 5.0 29.2 1.0 CD1 A:PHE75 5.0 41.0 1.0

Sodium binding site 2 out of 2 in the Human Fcrn Extra-Cellular Domain Complexed with Fab Fragment of Rozanolixizumab


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Human Fcrn Extra-Cellular Domain Complexed with Fab Fragment of Rozanolixizumab within 5.0Å range: probe atom residue distance (Å) B Occ H:Na301 b:58.6 occ:1.00 OG H:SER53 3.3 52.2 1.0 CB H:SER53 3.3 52.8 1.0 O H:ASN31 3.4 40.1 1.0 NZ A:LYS109 3.5 40.7 1.0 OE2 A:GLU116 3.5 34.1 1.0 N H:GLY33 3.6 39.0 1.0 CG1 H:ILE100 3.7 40.8 1.0 OE1 A:GLU116 3.9 33.1 1.0 N H:SER53 3.9 52.8 1.0 CD A:GLU116 3.9 33.4 1.0 CD1 H:ILE100 3.9 42.0 1.0 O H:ILE100 4.0 40.3 1.0 CE A:LYS109 4.1 38.8 1.0 C H:TYR32 4.2 39.0 1.0 CA H:SER53 4.2 53.0 1.0 C H:ASN31 4.3 39.7 1.0 CA H:GLY33 4.3 39.3 1.0 CA H:TYR32 4.5 38.9 1.0 N H:TYR32 4.6 39.1 1.0 CD A:LYS109 4.7 36.2 1.0 C H:ILE100 4.8 40.1 1.0

B.Smith, A.Kiessling, R.Lledo-Garcia, K.L.Dixon, L.Christodoulou, M.C.Catley, P.Atherfold, L.E.D'hooghe, H.Finney, K.Greenslade, H.Hailu, L.Kevorkian, D.Lightwood, C.Meier, R.Munro, O.Qureshi, K.Sarkar, S.P.Shaw, R.Tewari, A.Turner, K.Tyson, S.West, S.Shaw, F.R.Brennan. Generation and Characterization of A High Affinity Anti-Human Fcrn Antibody, Rozanolixizumab, and the Effects of Different Molecular Formats on the Reduction of Plasma Igg Concentration. Mabs V. 10 1111 2018.
ISSN: ESSN 1942-0870
PubMed: 30130439
DOI: 10.1080/19420862.2018.1505464