Sodium in PDB 6bcj: Cryo-Em Structure of TRPM4 in Apo State with Short Coiled Coil at 3.1 Angstrom Resolution

The binding sites of Sodium atom in the Cryo-Em Structure of TRPM4 in Apo State with Short Coiled Coil at 3.1 Angstrom Resolution (pdb code 6bcj). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 4 binding sites of Sodium where determined in the Cryo-Em Structure of TRPM4 in Apo State with Short Coiled Coil at 3.1 Angstrom Resolution, PDB code: 6bcj:
Jump to Sodium binding site number: 1; 2; 3; 4;

Sodium binding site 1 out of 4 in the Cryo-Em Structure of TRPM4 in Apo State with Short Coiled Coil at 3.1 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Cryo-Em Structure of TRPM4 in Apo State with Short Coiled Coil at 3.1 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Na1301 b:15.3 occ:1.00 NA A:NA1302 3.1 33.5 1.0 O C:GLY972 3.8 13.7 1.0 O A:GLY972 3.9 14.8 1.0 O B:GLY972 3.9 13.6 1.0 O D:GLY972 3.9 11.2 1.0 NE2 D:GLN973 4.7 13.4 1.0 NE2 A:GLN973 4.7 15.0 1.0 NE2 C:GLN973 4.7 14.2 1.0 NE2 B:GLN973 4.7 14.0 1.0 C C:GLY972 4.8 13.7 1.0 C A:GLY972 4.8 14.8 1.0 C B:GLY972 4.8 13.6 1.0 C D:GLY972 4.9 11.2 1.0

Sodium binding site 2 out of 4 in the Cryo-Em Structure of TRPM4 in Apo State with Short Coiled Coil at 3.1 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Cryo-Em Structure of TRPM4 in Apo State with Short Coiled Coil at 3.1 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Na1302 b:33.5 occ:1.00 NA A:NA1301 3.1 15.3 1.0 CA C:GLY972 4.4 13.7 1.0 CA B:GLY972 4.4 13.6 1.0 CA A:GLY972 4.4 14.8 1.0 CA D:GLY972 4.4 11.2 1.0 O B:GLY972 4.6 13.6 1.0 O C:GLY972 4.6 13.7 1.0 O A:GLY972 4.6 14.8 1.0 O D:GLY972 4.6 11.2 1.0 O A:PHE971 4.6 10.8 1.0 O C:PHE971 4.6 9.3 1.0 O D:PHE971 4.6 9.6 1.0 O B:PHE971 4.6 9.5 1.0 O B:HOH1301 4.8 29.9 1.0 O C:HOH1301 4.8 47.4 1.0 O D:HOH2001 4.8 41.0 1.0 O A:HOH1401 4.8 24.5 1.0 C B:GLY972 5.0 13.6 1.0 C C:GLY972 5.0 13.7 1.0 C A:GLY972 5.0 14.8 1.0 C D:GLY972 5.0 11.2 1.0

Sodium binding site 3 out of 4 in the Cryo-Em Structure of TRPM4 in Apo State with Short Coiled Coil at 3.1 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of Cryo-Em Structure of TRPM4 in Apo State with Short Coiled Coil at 3.1 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Na1303 b:67.6 occ:1.00 O B:HOH1301 4.4 29.9 1.0 O C:HOH1301 4.4 47.4 1.0 O D:HOH2001 4.4 41.0 1.0 O A:HOH1401 4.4 24.5 1.0 NA A:NA1304 4.5 51.6 1.0

Sodium binding site 4 out of 4 in the Cryo-Em Structure of TRPM4 in Apo State with Short Coiled Coil at 3.1 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 4 of Cryo-Em Structure of TRPM4 in Apo State with Short Coiled Coil at 3.1 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Na1304 b:51.6 occ:1.00 O A:HOH1402 3.2 15.5 1.0 O C:HOH1302 3.2 26.4 1.0 O B:HOH1302 3.2 44.6 1.0 O D:HOH2002 3.2 42.1 1.0 NA A:NA1303 4.5 67.6 1.0 CD1 A:ILE1036 4.9 18.3 1.0 CD1 C:ILE1036 4.9 11.1 1.0 CD1 D:ILE1036 4.9 16.5 1.0 CD1 B:ILE1036 4.9 14.1 1.0

J.Guo, J.She, W.Zeng, Q.Chen, X.C.Bai, Y.Jiang. Structures of the Calcium-Activated, Non-Selective Cation Channel TRPM4. Nature V. 552 205 2017.
ISSN: ESSN 1476-4687
PubMed: 29211714
DOI: 10.1038/NATURE24997