Sodium in PDB 6aei: Cryo-Em Structure of the Receptor-Activated TRPC5 Ion Channel

The binding sites of Sodium atom in the Cryo-Em Structure of the Receptor-Activated TRPC5 Ion Channel (pdb code 6aei). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 5 binding sites of Sodium where determined in the Cryo-Em Structure of the Receptor-Activated TRPC5 Ion Channel, PDB code: 6aei:
Jump to Sodium binding site number: 1; 2; 3; 4; 5;

Sodium binding site 1 out of 5 in the Cryo-Em Structure of the Receptor-Activated TRPC5 Ion Channel


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Cryo-Em Structure of the Receptor-Activated TRPC5 Ion Channel within 5.0Å range: probe atom residue distance (Å) B Occ A:Na801 b:30.0 occ:1.00 N A:GLY581 4.0 37.5 1.0 CA A:GLY581 4.0 37.5 1.0 CA D:GLY581 4.4 27.0 1.0 N D:GLY581 4.5 27.0 1.0 CA C:GLY581 4.8 31.8 1.0 N C:GLY581 4.9 31.8 1.0

Sodium binding site 2 out of 5 in the Cryo-Em Structure of the Receptor-Activated TRPC5 Ion Channel


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Cryo-Em Structure of the Receptor-Activated TRPC5 Ion Channel within 5.0Å range: probe atom residue distance (Å) B Occ A:Na802 b:30.0 occ:1.00 OD1 A:ASN436 2.2 88.8 1.0 OE1 A:GLU421 2.7 0.6 1.0 OD2 A:ASP439 2.7 79.7 1.0 OE2 A:GLU418 2.8 0.1 1.0 CG A:ASN436 3.4 88.8 1.0 OE1 A:GLU418 3.5 0.1 1.0 CD A:GLU421 3.5 0.6 1.0 CD A:GLU418 3.5 0.1 1.0 OE2 A:GLU421 3.6 0.6 1.0 CG A:ASP439 3.9 79.7 1.0 ND2 A:ASN436 4.2 88.8 1.0 CB A:ASN436 4.5 88.8 1.0 CA A:ASN436 4.5 88.8 1.0 CB A:ASP439 4.7 79.7 1.0 OD1 A:ASP439 4.8 79.7 1.0 CG A:GLU421 4.9 0.6 1.0

Sodium binding site 3 out of 5 in the Cryo-Em Structure of the Receptor-Activated TRPC5 Ion Channel


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of Cryo-Em Structure of the Receptor-Activated TRPC5 Ion Channel within 5.0Å range: probe atom residue distance (Å) B Occ B:Na801 b:30.0 occ:1.00 OD1 B:ASN436 2.7 90.9 1.0 OD2 B:ASP439 2.7 82.2 1.0 OE2 B:GLU418 2.8 0.5 1.0 OE1 B:GLU421 3.0 0.1 1.0 OE2 B:GLU421 3.5 0.1 1.0 CD B:GLU421 3.7 0.1 1.0 CD B:GLU418 3.7 0.5 1.0 OE1 B:GLU418 3.8 0.5 1.0 CG B:ASN436 3.9 90.9 1.0 CG B:ASP439 3.9 82.2 1.0 ND2 B:ASN436 4.7 90.9 1.0 OD1 B:ASP439 4.7 82.2 1.0 CB B:ASP439 4.8 82.2 1.0 NH2 B:ARG492 4.8 64.7 1.0 CA B:ASN436 4.9 90.9 1.0 CB B:ASN436 4.9 90.9 1.0

Sodium binding site 4 out of 5 in the Cryo-Em Structure of the Receptor-Activated TRPC5 Ion Channel


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 4 of Cryo-Em Structure of the Receptor-Activated TRPC5 Ion Channel within 5.0Å range: probe atom residue distance (Å) B Occ C:Na801 b:30.0 occ:1.00 OD1 C:ASN436 2.2 86.8 1.0 OD2 C:ASP439 2.3 78.3 1.0 OE2 C:GLU418 3.0 97.2 1.0 OE1 C:GLU421 3.3 0.6 1.0 CG C:ASN436 3.4 86.8 1.0 CG C:ASP439 3.6 78.3 1.0 OE1 C:GLU418 3.7 97.2 1.0 CD C:GLU418 3.7 97.2 1.0 OE2 C:GLU421 4.0 0.6 1.0 CD C:GLU421 4.1 0.6 1.0 ND2 C:ASN436 4.3 86.8 1.0 CA C:ASN436 4.3 86.8 1.0 CB C:ASN436 4.4 86.8 1.0 OD1 C:ASP439 4.4 78.3 1.0 CB C:ASP439 4.5 78.3 1.0 NH2 C:ARG492 4.6 60.2 1.0 O C:TRP435 4.7 76.4 1.0 N C:ASN436 4.7 86.8 1.0 NH1 C:ARG492 4.9 60.2 1.0 C C:TRP435 4.9 76.4 1.0

Sodium binding site 5 out of 5 in the Cryo-Em Structure of the Receptor-Activated TRPC5 Ion Channel


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 5 of Cryo-Em Structure of the Receptor-Activated TRPC5 Ion Channel within 5.0Å range: probe atom residue distance (Å) B Occ D:Na801 b:30.0 occ:1.00 OD1 D:ASN436 2.3 79.5 1.0 OD2 D:ASP439 2.7 70.7 1.0 OE1 D:GLU421 2.9 96.3 1.0 OE2 D:GLU418 2.9 89.2 1.0 CG D:ASN436 3.5 79.5 1.0 OE2 D:GLU421 3.6 96.3 1.0 CD D:GLU421 3.6 96.3 1.0 OE1 D:GLU418 3.7 89.2 1.0 CD D:GLU418 3.7 89.2 1.0 CG D:ASP439 3.9 70.7 1.0 ND2 D:ASN436 4.3 79.5 1.0 CB D:ASN436 4.6 79.5 1.0 CA D:ASN436 4.6 79.5 1.0 CB D:ASP439 4.8 70.7 1.0 OD1 D:ASP439 4.8 70.7 1.0 NH2 D:ARG492 5.0 53.4 1.0

J.Duan, J.Li, G.L.Chen, Y.Ge, J.Liu, K.Xie, X.Peng, W.Zhou, J.Zhong, Y.Zhang, J.Xu, C.Xue, B.Liang, L.Zhu, W.Liu, C.Zhang, X.L.Tian, J.Wang, D.E.Clapham, B.Zeng, Z.Li, J.Zhang. Cryo-Em Structure of TRPC5 at 2.8- Angstrom Resolution Reveals Unique and Conserved Structural Elements Essential For Channel Function. Sci Adv V. 5 2019.
ISSN: ESSN 2375-2548
PubMed: 31355338
DOI: 10.1126/SCIADV.AAW7935