Sodium in PDB 5udp: High Resolution X-Ray Crystal Structure of Synthetic Insulin Lispro

The structure of High Resolution X-Ray Crystal Structure of Synthetic Insulin Lispro, PDB code: 5udp was solved by K.Mandal, B.Dhayalan, S.B.H.Kent, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	25.72 / 1.35
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	46.644, 61.470, 59.148, 90.00, 110.60, 90.00
R / Rfree (%)	16 / 19.4

The structure of High Resolution X-Ray Crystal Structure of Synthetic Insulin Lispro also contains other interesting chemical elements:

Chlorine	(Cl)	2 atoms
Zinc	(Zn)	2 atoms

The binding sites of Sodium atom in the High Resolution X-Ray Crystal Structure of Synthetic Insulin Lispro (pdb code 5udp). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the High Resolution X-Ray Crystal Structure of Synthetic Insulin Lispro, PDB code: 5udp:

Sodium binding site 1 out of 1 in the High Resolution X-Ray Crystal Structure of Synthetic Insulin Lispro


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of High Resolution X-Ray Crystal Structure of Synthetic Insulin Lispro within 5.0Å range: probe atom residue distance (Å) B Occ C:Na102 b:33.4 occ:1.00 O C:ASN18 2.3 25.8 1.0 O C:HOH206 2.5 30.0 1.0 O C:HOH203 2.5 37.7 1.0 O C:CYS20 2.7 31.3 1.0 C C:ASN18 3.2 23.3 1.0 C C:CYS20 3.8 29.5 1.0 N C:CYS20 3.9 24.7 1.0 N C:TYR19 4.0 22.9 1.0 CA C:ASN18 4.0 22.6 1.0 C C:TYR19 4.1 24.1 1.0 O C:GLU17 4.1 27.0 0.5 O C:GLU17 4.1 24.8 0.6 CA C:TYR19 4.2 23.1 1.0 O D:HOH201 4.2 65.2 1.0 CA C:CYS20 4.4 24.9 1.0 OD1 C:ASN18 4.5 22.9 1.0 CG C:ASN18 4.8 22.0 1.0 O C:TYR19 4.8 25.9 1.0 N C:ASN21 4.9 32.8 1.0 O C:ASN21 5.0 48.1 1.0

B.Dhayalan, K.Mandal, N.Rege, M.A.Weiss, S.H.Eitel, T.Meier, R.O.Schoenleber, S.B.Kent. Scope and Limitations of Fmoc Chemistry Spps-Based Approaches to the Total Synthesis of Insulin Lispro Via Ester Insulin. Chemistry V. 23 1709 2017.
ISSN: ISSN 1521-3765
PubMed: 27905149
DOI: 10.1002/CHEM.201605578