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Sodium in PDB 5o2b: Crystal Structure of WNK3 Kinase Domain in A Diphosphorylated State and in A Complex with the Inhibitor Pp-121

Enzymatic activity of Crystal Structure of WNK3 Kinase Domain in A Diphosphorylated State and in A Complex with the Inhibitor Pp-121

All present enzymatic activity of Crystal Structure of WNK3 Kinase Domain in A Diphosphorylated State and in A Complex with the Inhibitor Pp-121:
2.7.11.1;

Protein crystallography data

The structure of Crystal Structure of WNK3 Kinase Domain in A Diphosphorylated State and in A Complex with the Inhibitor Pp-121, PDB code: 5o2b was solved by D.M.Pinkas, J.C.Bufton, J.A.Newman, O.Borkowska, R.Chalk, N.A.Burgess-Brown, F.Von Delft, C.H.Arrowsmith, A.M.Edwards, C.Bountra, A.Bullock, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.05 / 2.04
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 60.160, 71.253, 67.800, 90.00, 103.88, 90.00
R / Rfree (%) 19.9 / 24

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure of WNK3 Kinase Domain in A Diphosphorylated State and in A Complex with the Inhibitor Pp-121 (pdb code 5o2b). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of WNK3 Kinase Domain in A Diphosphorylated State and in A Complex with the Inhibitor Pp-121, PDB code: 5o2b:

Sodium binding site 1 out of 1 in 5o2b

Go back to Sodium Binding Sites List in 5o2b
Sodium binding site 1 out of 1 in the Crystal Structure of WNK3 Kinase Domain in A Diphosphorylated State and in A Complex with the Inhibitor Pp-121


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of WNK3 Kinase Domain in A Diphosphorylated State and in A Complex with the Inhibitor Pp-121 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na502

b:47.2
occ:1.00
O A:HOH614 2.2 39.5 1.0
O A:HOH673 2.3 51.5 1.0
O A:HOH688 2.4 49.0 1.0
OD1 A:ASP150 3.6 38.1 1.0
OD2 A:ASP150 4.1 35.2 1.0
CG A:ASP150 4.2 32.4 1.0
O A:HOH650 4.3 45.4 1.0
OE1 A:GLU152 4.7 47.1 1.0

Reference:

D.M.Pinkas, G.M.Daubner, J.C.Bufton, S.G.Bartual, C.E.Sanvitale, D.R.Alessi, A.Bullock. Crystal Structure of WNK3 Kinase Domain in A Diphosphorylated State and in A Complex with the Inhibitor Pp-121 To Be Published.
Page generated: Tue Dec 15 11:22:49 2020

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