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Sodium in PDB 5lz2: Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2
Enzymatic activity of Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2
All present enzymatic activity of Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2:
3.1.1.47;
3.1.1.47;
Protein crystallography data
The structure of Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2, PDB code: 5lz2
was solved by
A.Woolford,
P.Day,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 32.42 / 2.10 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 99.971, 90.649, 51.321, 90.00, 111.82, 90.00 |
| R / Rfree (%) | 16.7 / 22.8 |
Other elements in 5lz2:
The structure of Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2 also contains other interesting chemical elements:
| Chlorine | (Cl) | 1 atom |
Sodium Binding Sites:
The binding sites of Sodium atom in the Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2
(pdb code 5lz2). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2, PDB code: 5lz2:
In total only one binding site of Sodium was determined in the Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2, PDB code: 5lz2:
Sodium binding site 1 out of 1 in 5lz2
Go back to
Sodium Binding Sites List in 5lz2
Sodium binding site 1 out
of 1 in the Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Sodium with other atoms in the Na binding
site number 1 of Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2 within 5.0Å range:
|
Reference:
A.J.Woolford,
P.J.Day,
V.Beneton,
V.Berdini,
J.E.Coyle,
Y.Dudit,
P.Grondin,
P.Huet,
L.Y.Lee,
E.S.Manas,
R.L.Mcmenamin,
C.W.Murray,
L.W.Page,
V.K.Patel,
F.Potvain,
S.J.Rich,
Y.Sang,
D.O.Somers,
L.Trottet,
Z.Wan,
X.Zhang.
Fragment-Based Approach to the Development of An Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2). J. Med. Chem. V. 59 10738 2016.
ISSN: ISSN 1520-4804
PubMed: 27933945
DOI: 10.1021/ACS.JMEDCHEM.6B01427
Page generated: Mon Oct 7 22:26:42 2024
ISSN: ISSN 1520-4804
PubMed: 27933945
DOI: 10.1021/ACS.JMEDCHEM.6B01427
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