Sodium in PDB 5llm: Structure of the Thermostabilized EAAT1 Cryst Mutant in Complex with L-Asp and the Allosteric Inhibitor UCPH101

The structure of Structure of the Thermostabilized EAAT1 Cryst Mutant in Complex with L-Asp and the Allosteric Inhibitor UCPH101, PDB code: 5llm was solved by J.Canul-Tec, R.Assal, P.Legrand, N.Reyes, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	34.50 / 3.25
Space group	P 63
Cell size a, b, c (Å), α, β, γ (°)	123.270, 123.270, 89.870, 90.00, 90.00, 120.00
R / Rfree (%)	21.9 / 24

The binding sites of Sodium atom in the Structure of the Thermostabilized EAAT1 Cryst Mutant in Complex with L-Asp and the Allosteric Inhibitor UCPH101 (pdb code 5llm). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Structure of the Thermostabilized EAAT1 Cryst Mutant in Complex with L-Asp and the Allosteric Inhibitor UCPH101, PDB code: 5llm:

Sodium binding site 1 out of 1 in the Structure of the Thermostabilized EAAT1 Cryst Mutant in Complex with L-Asp and the Allosteric Inhibitor UCPH101


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Structure of the Thermostabilized EAAT1 Cryst Mutant in Complex with L-Asp and the Allosteric Inhibitor UCPH101 within 5.0Å range: probe atom residue distance (Å) B Occ A:Na601 b:99.1 occ:1.00 O A:ALA420 2.3 0.6 1.0 O A:SER417 2.3 0.4 1.0 O A:THR376 2.3 1.0 1.0 CG A:MET379 2.3 0.2 1.0 SD A:MET379 2.7 0.9 1.0 CE A:MET379 2.8 0.6 1.0 C A:ALA420 3.4 0.4 1.0 O A:ILE418 3.4 0.8 1.0 C A:THR376 3.4 0.4 1.0 C A:SER417 3.5 0.7 1.0 CB A:MET379 3.6 0.2 1.0 C A:ILE418 3.8 0.4 1.0 CA A:ALA420 4.0 0.1 1.0 N A:ALA420 4.1 0.1 1.0 CA A:ILE418 4.1 0.1 1.0 CB A:ALA420 4.2 0.0 1.0 N A:ILE418 4.2 0.8 1.0 O A:ILE377 4.2 0.8 1.0 CA A:THR376 4.2 0.9 1.0 N A:ILE377 4.4 0.3 1.0 N A:ALA421 4.4 0.9 1.0 C A:GLY419 4.4 0.9 1.0 C A:ILE377 4.5 0.4 1.0 CA A:SER417 4.6 0.8 1.0 N A:GLY419 4.6 0.4 1.0 CA A:ILE377 4.6 0.0 1.0 O A:GLY419 4.7 0.7 1.0 CA A:ALA421 4.7 0.4 1.0 OG1 A:THR376 4.8 0.6 1.0 CA A:MET379 4.8 0.1 1.0 N A:MET379 4.8 0.8 1.0 C A:ALA421 4.8 0.7 1.0 O A:ALA416 4.9 0.3 1.0

J.C.Canul-Tec, R.Assal, E.Cirri, P.Legrand, S.Brier, J.Chamot-Rooke, N.Reyes. Structure and Allosteric Inhibition of Excitatory Amino Acid Transporter 1. Nature V. 544 446 2017.
ISSN: ESSN 1476-4687
PubMed: 28424515
DOI: 10.1038/NATURE22064