Sodium in PDB 4x88: E178D Selectivity Filter Mutant of Navms Voltage-Gated Pore

The structure of E178D Selectivity Filter Mutant of Navms Voltage-Gated Pore, PDB code: 4x88 was solved by C.E.Naylor, C.Bagneris, B.A.Wallace, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.93 / 3.50
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	80.230, 336.020, 80.300, 90.00, 90.00, 90.00
R / Rfree (%)	19.8 / 20.5

The binding sites of Sodium atom in the E178D Selectivity Filter Mutant of Navms Voltage-Gated Pore (pdb code 4x88). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 4 binding sites of Sodium where determined in the E178D Selectivity Filter Mutant of Navms Voltage-Gated Pore, PDB code: 4x88:
Jump to Sodium binding site number: 1; 2; 3; 4;

Sodium binding site 1 out of 4 in the E178D Selectivity Filter Mutant of Navms Voltage-Gated Pore


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of E178D Selectivity Filter Mutant of Navms Voltage-Gated Pore within 5.0Å range: probe atom residue distance (Å) B Occ A:Na303 b:30.0 occ:0.50 NA A:NA304 3.9 30.0 0.5 O B:THR176 4.8 23.2 1.0 O A:THR176 4.8 26.0 1.0

Sodium binding site 2 out of 4 in the E178D Selectivity Filter Mutant of Navms Voltage-Gated Pore


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of E178D Selectivity Filter Mutant of Navms Voltage-Gated Pore within 5.0Å range: probe atom residue distance (Å) B Occ A:Na304 b:30.0 occ:0.50 NA A:NA303 3.9 30.0 0.5 O A:LEU177 4.5 24.9 1.0 CA A:ASP178 4.9 25.4 1.0 O B:LEU177 4.9 23.8 1.0 OD1 A:ASP178 5.0 27.6 1.0

Sodium binding site 3 out of 4 in the E178D Selectivity Filter Mutant of Navms Voltage-Gated Pore


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of E178D Selectivity Filter Mutant of Navms Voltage-Gated Pore within 5.0Å range: probe atom residue distance (Å) B Occ C:Na303 b:30.0 occ:0.50 NA C:NA304 4.2 30.0 0.5 O D:THR176 4.9 26.2 1.0 O C:THR176 4.9 24.7 1.0

Sodium binding site 4 out of 4 in the E178D Selectivity Filter Mutant of Navms Voltage-Gated Pore


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 4 of E178D Selectivity Filter Mutant of Navms Voltage-Gated Pore within 5.0Å range: probe atom residue distance (Å) B Occ C:Na304 b:30.0 occ:0.50 NA C:NA303 4.2 30.0 0.5 N D:SER179 4.6 26.6 1.0 N C:SER179 4.7 26.1 1.0 OD1 D:ASP178 4.7 28.0 1.0 O D:LEU177 4.8 36.5 1.0 OD1 C:ASP178 4.8 27.8 1.0 CA D:ASP178 4.9 26.6 1.0 O C:LEU177 4.9 31.4 1.0 CA C:ASP178 4.9 26.0 1.0

C.E.Naylor, C.Bagneris, P.G.Decaen, A.Sula, A.Scaglione, D.E.Clapham, B.A.Wallace. Molecular Basis of Ion Permeability in A Voltage-Gated Sodium Channel. Embo J. V. 35 820 2016.
ISSN: ESSN 1460-2075
PubMed: 26873592
DOI: 10.15252/EMBJ.201593285