Sodium in PDB 4wx2: Crystal Structure of Tryptophan Synthase From Salmonella Typhimurium in Complex with Two F6F Molecules in the Alpha-Site and One F6F Molecule in the Beta-Site

Enzymatic activity of Crystal Structure of Tryptophan Synthase From Salmonella Typhimurium in Complex with Two F6F Molecules in the Alpha-Site and One F6F Molecule in the Beta-Site

All present enzymatic activity of Crystal Structure of Tryptophan Synthase From Salmonella Typhimurium in Complex with Two F6F Molecules in the Alpha-Site and One F6F Molecule in the Beta-Site:
4.2.1.20;

Protein crystallography data

The structure of Crystal Structure of Tryptophan Synthase From Salmonella Typhimurium in Complex with Two F6F Molecules in the Alpha-Site and One F6F Molecule in the Beta-Site, PDB code: 4wx2 was solved by E.Hilario, B.G.Caulkins, R.P.Young, D.Niks, M.F.Dunn, L.J.Mueller, L.Fan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	20.95 / 1.75
*Space group*	C 1 2 1
*Cell size a, b, c (Å), α, β, γ (°)*	183.809, 58.890, 67.270, 90.00, 95.21, 90.00
*R / R_free (%)*	15.8 / 18.9

Other elements in 4wx2:

Fluorine

(F)

9 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure of Tryptophan Synthase From Salmonella Typhimurium in Complex with Two F6F Molecules in the Alpha-Site and One F6F Molecule in the Beta-Site (pdb code 4wx2). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of Tryptophan Synthase From Salmonella Typhimurium in Complex with Two F6F Molecules in the Alpha-Site and One F6F Molecule in the Beta-Site, PDB code: 4wx2:

Sodium binding site 1 out of 1 in 4wx2

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Sodium Binding Sites List in 4wx2

Sodium binding site 1 out of 1 in the Crystal Structure of Tryptophan Synthase From Salmonella Typhimurium in Complex with Two F6F Molecules in the Alpha-Site and One F6F Molecule in the Beta-Site

Mono view

Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of Tryptophan Synthase From Salmonella Typhimurium in Complex with Two F6F Molecules in the Alpha-Site and One F6F Molecule in the Beta-Site within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
B:Na405 b:14.6 occ:0.90	O	B:HOH817	2.3	15.5	1.0
	O	B:GLY232	2.3	20.3	1.0
	O	B:HOH818	2.3	16.5	1.0
	O	B:PHE306	2.3	19.6	1.0
	O	B:SER308	2.3	16.9	1.0
	C	B:GLY232	3.4	17.9	1.0
	C	B:PHE306	3.5	19.6	1.0
	C	B:SER308	3.5	17.3	1.0
	CG	B:PRO270	3.8	16.1	1.0
	CD	B:PRO270	3.9	16.6	1.0
	N	B:SER308	4.0	18.6	1.0
	CA	B:GLY232	4.1	17.0	1.0
	O	B:GLY268	4.2	18.1	1.0
	O	B:LEU304	4.3	20.1	1.0
	CA	B:PHE306	4.3	20.1	1.0
	CB	B:PHE306	4.3	20.3	1.0
	CD2	B:PHE306	4.3	20.4	1.0
	CA	B:SER308	4.4	17.7	1.0
	OG	B:SER297	4.4	21.9	1.0
	N	B:PHE306	4.4	19.9	1.0
	C	B:PRO307	4.5	20.2	1.0
	N	B:PRO307	4.5	20.5	1.0
	N	B:VAL309	4.5	15.8	1.0
	N	B:GLY233	4.5	17.8	1.0
	O	B:VAL231	4.5	17.0	1.0
	CA	B:PRO307	4.6	20.2	1.0
	CA	B:VAL309	4.6	16.3	1.0
	CG	B:PHE306	4.7	20.4	1.0
	CB	B:VAL309	4.7	16.2	1.0
	OE2	B:GLU256	4.8	16.6	1.0
	CA	B:GLY233	4.9	17.5	1.0
	N	B:GLY232	5.0	16.4	1.0

Reference:

E.Hilario, B.G.Caulkins, Y.M.Huang, W.You, C.E.Chang, L.J.Mueller, M.F.Dunn, L.Fan. Visualizing the Tunnel in Tryptophan Synthase with Crystallography: Insights Into A Selective Filter For Accommodating Indole and Rejecting Water. Biochim.Biophys.Acta V.1864 268 2016.
ISSN: ISSN 0006-3002
PubMed: 26708480
DOI: 10.1016/J.BBAPAP.2015.12.006

Page generated: Mon Oct 7 18:55:41 2024

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