Sodium in PDB 4qxv: Crystal Structure of Human Transthyretin in Complex with Luteolin at 1.1 A Resolution

The structure of Crystal Structure of Human Transthyretin in Complex with Luteolin at 1.1 A Resolution, PDB code: 4qxv was solved by A.Begum, A.Olofsson, A.E.Sauer-Eriksson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	35.52 / 1.12
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	42.694, 85.914, 63.994, 90.00, 90.00, 90.00
R / Rfree (%)	13.3 / 15.2

The binding sites of Sodium atom in the Crystal Structure of Human Transthyretin in Complex with Luteolin at 1.1 A Resolution (pdb code 4qxv). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of Human Transthyretin in Complex with Luteolin at 1.1 A Resolution, PDB code: 4qxv:

Sodium binding site 1 out of 1 in the Crystal Structure of Human Transthyretin in Complex with Luteolin at 1.1 A Resolution


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of Human Transthyretin in Complex with Luteolin at 1.1 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Na204 b:39.7 occ:1.00 O A:ASP99 2.1 25.5 1.0 O A:HOH404 2.3 36.6 1.0 O A:HOH403 2.4 30.7 1.0 O A:HOH401 2.4 37.0 0.7 O A:HOH402 2.4 33.0 0.5 O A:HOH405 2.6 43.5 1.0 C A:ASP99 3.3 24.7 1.0 HB2 A:ASP99 3.6 30.0 1.0 OE1 A:GLU66 3.8 19.3 0.3 HA A:SER100 3.8 34.0 1.0 HA A:ASP99 4.0 27.9 1.0 CA A:ASP99 4.1 23.2 1.0 OE2 A:GLU66 4.1 20.9 0.7 CB A:ASP99 4.3 25.0 1.0 O A:HOH382 4.3 24.1 0.5 N A:SER100 4.3 25.9 1.0 O A:HOH412 4.3 37.9 0.5 CA A:SER100 4.5 28.3 1.0 CD A:GLU66 4.6 18.2 0.3 HG A:SER100 4.7 39.3 1.0 CD A:GLU66 4.7 19.8 0.7 OE2 A:GLU66 4.8 19.1 0.3 OE1 A:GLU66 4.8 18.4 0.7 CG A:ASP99 5.0 25.8 1.0

I.Iakovleva, A.Begum, M.Pokrzywa, M.Walfridsson, A.E.Sauer-Eriksson, A.Olofsson. The Flavonoid Luteolin, But Not Luteolin-7-O-Glucoside, Prevents A Transthyretin Mediated Toxic Response. Plos One V. 10 28222 2015.
ISSN: ESSN 1932-6203
PubMed: 26020516
DOI: 10.1371/JOURNAL.PONE.0128222