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Sodium in PDB 4ny8: Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site
Enzymatic activity of Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site
All present enzymatic activity of Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site:
2.7.7.7;
2.7.7.7;
Protein crystallography data
The structure of Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site, PDB code: 4ny8
was solved by
M.-C.Koag,
K.Min,
A.F.Monzingo,
S.Lee,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 19.82 / 2.25 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 54.625, 79.288, 54.838, 90.00, 105.97, 90.00 |
| R / Rfree (%) | 20.6 / 26.5 |
Other elements in 4ny8:
The structure of Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site also contains other interesting chemical elements:
| Manganese | (Mn) | 2 atoms |
Sodium Binding Sites:
The binding sites of Sodium atom in the Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site
(pdb code 4ny8). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site, PDB code: 4ny8:
Jump to Sodium binding site number: 1; 2;
In total 2 binding sites of Sodium where determined in the Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site, PDB code: 4ny8:
Jump to Sodium binding site number: 1; 2;
Sodium binding site 1 out of 2 in 4ny8
Go back to
Sodium Binding Sites List in 4ny8
Sodium binding site 1 out
of 2 in the Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Sodium with other atoms in the Na binding
site number 1 of Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site within 5.0Å range:
|
Sodium binding site 2 out of 2 in 4ny8
Go back to
Sodium Binding Sites List in 4ny8
Sodium binding site 2 out
of 2 in the Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Sodium with other atoms in the Na binding
site number 2 of Dna Polymerase Beta with O6MG in the Template Base Opposite to Incoming Non-Hydrolyzable Ctp with Manganese in the Active Site within 5.0Å range:
|
Reference:
M.C.Koag,
S.Lee.
Metal-Dependent Conformational Activation Explains Highly Promutagenic Replication Across O6-Methylguanine By Human Dna Polymerase Beta. J.Am.Chem.Soc. V. 136 5709 2014.
ISSN: ISSN 0002-7863
PubMed: 24694247
DOI: 10.1021/JA500172D
Page generated: Tue Dec 15 06:56:08 2020
ISSN: ISSN 0002-7863
PubMed: 24694247
DOI: 10.1021/JA500172D
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