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Sodium in PDB 4nm2: Structure of Human Dna Polymerase Beta Complexed with A Nicked Dna Containing A 8BRG-G at N-1 Position and G-C at N Position

Enzymatic activity of Structure of Human Dna Polymerase Beta Complexed with A Nicked Dna Containing A 8BRG-G at N-1 Position and G-C at N Position

All present enzymatic activity of Structure of Human Dna Polymerase Beta Complexed with A Nicked Dna Containing A 8BRG-G at N-1 Position and G-C at N Position:
2.7.7.7;

Protein crystallography data

The structure of Structure of Human Dna Polymerase Beta Complexed with A Nicked Dna Containing A 8BRG-G at N-1 Position and G-C at N Position, PDB code: 4nm2 was solved by M.-C.Koag, K.Min, A.F.Monzingo, S.Lee, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 52.81 / 2.52
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 54.731, 80.202, 55.109, 90.00, 106.60, 90.00
R / Rfree (%) 20 / 27.7

Other elements in 4nm2:

The structure of Structure of Human Dna Polymerase Beta Complexed with A Nicked Dna Containing A 8BRG-G at N-1 Position and G-C at N Position also contains other interesting chemical elements:

Bromine (Br) 1 atom

Sodium Binding Sites:

The binding sites of Sodium atom in the Structure of Human Dna Polymerase Beta Complexed with A Nicked Dna Containing A 8BRG-G at N-1 Position and G-C at N Position (pdb code 4nm2). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Structure of Human Dna Polymerase Beta Complexed with A Nicked Dna Containing A 8BRG-G at N-1 Position and G-C at N Position, PDB code: 4nm2:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in 4nm2

Go back to Sodium Binding Sites List in 4nm2
Sodium binding site 1 out of 2 in the Structure of Human Dna Polymerase Beta Complexed with A Nicked Dna Containing A 8BRG-G at N-1 Position and G-C at N Position


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Structure of Human Dna Polymerase Beta Complexed with A Nicked Dna Containing A 8BRG-G at N-1 Position and G-C at N Position within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na401

b:44.1
occ:1.00
O A:THR101 2.9 32.8 1.0
NA A:NA402 3.5 32.9 1.0
C A:THR101 3.8 30.0 1.0
CA A:ARG102 4.2 30.8 1.0
N A:ARG102 4.4 29.7 1.0
OG1 A:THR101 4.6 25.2 1.0
C A:ARG102 4.7 33.1 1.0
O A:ARG102 4.7 34.3 1.0
NZ A:LYS27 4.7 37.1 1.0
CB A:THR101 4.9 26.2 1.0
OP2 P:DG9 4.9 29.3 1.0
OP1 P:DG9 4.9 30.0 1.0
CA A:THR101 5.0 28.3 1.0

Sodium binding site 2 out of 2 in 4nm2

Go back to Sodium Binding Sites List in 4nm2
Sodium binding site 2 out of 2 in the Structure of Human Dna Polymerase Beta Complexed with A Nicked Dna Containing A 8BRG-G at N-1 Position and G-C at N Position


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Structure of Human Dna Polymerase Beta Complexed with A Nicked Dna Containing A 8BRG-G at N-1 Position and G-C at N Position within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na402

b:32.9
occ:1.00
O A:THR101 2.2 32.8 1.0
OP1 P:DG9 2.3 30.0 1.0
O A:ILE106 2.3 27.1 1.0
O A:VAL103 2.5 32.8 1.0
C A:THR101 3.2 30.0 1.0
C A:ILE106 3.3 26.9 1.0
C A:VAL103 3.4 30.6 1.0
P P:DG9 3.4 30.3 1.0
NA A:NA401 3.5 44.1 1.0
N A:ILE106 3.7 25.5 1.0
OP2 P:DG9 3.7 29.3 1.0
CA A:SER104 3.8 25.8 1.0
N A:GLY105 3.8 25.5 1.0
CA A:THR101 3.9 28.3 1.0
N A:SER104 4.0 28.1 1.0
CA A:ILE106 4.0 26.3 1.0
N A:VAL103 4.1 30.7 1.0
C A:SER104 4.2 25.7 1.0
C A:ARG102 4.2 33.1 1.0
N A:GLY107 4.3 28.3 1.0
N A:ARG102 4.3 29.7 1.0
CA A:VAL103 4.4 30.0 1.0
CB A:ILE106 4.5 26.3 1.0
O5' P:DG9 4.5 33.4 1.0
O3' P:DC8 4.5 29.7 1.0
CB A:THR101 4.5 26.2 1.0
CA A:ARG102 4.5 30.8 1.0
CA A:GLY107 4.6 29.4 1.0
C A:GLY105 4.6 26.3 1.0
O A:ARG102 4.6 34.3 1.0
CA A:GLY105 4.7 24.6 1.0
O A:LEU100 4.9 35.2 1.0
CB A:SER104 5.0 25.2 1.0

Reference:

M.C.Koag, K.Min, S.Lee. Structural Basis For Promutagenicity of 8-Halogenated Guanine. J.Biol.Chem. V. 289 6289 2014.
ISSN: ISSN 0021-9258
PubMed: 24425881
DOI: 10.1074/JBC.M113.537803
Page generated: Mon Oct 7 17:16:15 2024

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