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Sodium in PDB 4nm1: Structure of Human Dna Polymerase Beta Complexed with A Nicked Dna Containing A 8BRG-C at N-1 Position and G-C at N Position

Enzymatic activity of Structure of Human Dna Polymerase Beta Complexed with A Nicked Dna Containing A 8BRG-C at N-1 Position and G-C at N Position

All present enzymatic activity of Structure of Human Dna Polymerase Beta Complexed with A Nicked Dna Containing A 8BRG-C at N-1 Position and G-C at N Position:
2.7.7.7;

Protein crystallography data

The structure of Structure of Human Dna Polymerase Beta Complexed with A Nicked Dna Containing A 8BRG-C at N-1 Position and G-C at N Position, PDB code: 4nm1 was solved by M.-C.Koag, K.Min, A.F.Monzingo, S.Lee, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 52.71 / 2.42
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 50.749, 80.114, 55.272, 90.00, 107.52, 90.00
R / Rfree (%) 19.8 / 25.6

Other elements in 4nm1:

The structure of Structure of Human Dna Polymerase Beta Complexed with A Nicked Dna Containing A 8BRG-C at N-1 Position and G-C at N Position also contains other interesting chemical elements:

Bromine (Br) 1 atom
Magnesium (Mg) 2 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Structure of Human Dna Polymerase Beta Complexed with A Nicked Dna Containing A 8BRG-C at N-1 Position and G-C at N Position (pdb code 4nm1). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Structure of Human Dna Polymerase Beta Complexed with A Nicked Dna Containing A 8BRG-C at N-1 Position and G-C at N Position, PDB code: 4nm1:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in 4nm1

Go back to Sodium Binding Sites List in 4nm1
Sodium binding site 1 out of 2 in the Structure of Human Dna Polymerase Beta Complexed with A Nicked Dna Containing A 8BRG-C at N-1 Position and G-C at N Position


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Structure of Human Dna Polymerase Beta Complexed with A Nicked Dna Containing A 8BRG-C at N-1 Position and G-C at N Position within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na403

b:24.1
occ:1.00
O A:VAL65 2.3 25.0 1.0
O A:LEU62 2.4 25.7 1.0
O A:LYS60 2.4 26.9 1.0
O A:HOH505 2.5 17.8 1.0
OP1 D:DC3 2.5 30.1 1.0
C A:LYS60 3.5 27.5 1.0
C A:LEU62 3.5 28.4 1.0
C A:VAL65 3.5 25.1 1.0
P D:DC3 3.6 30.1 1.0
OP2 D:DC3 3.8 27.0 1.0
N A:VAL65 3.9 22.4 1.0
C A:LYS61 4.1 28.9 1.0
N A:GLY64 4.1 24.8 1.0
CA A:PRO63 4.1 27.0 1.0
O A:LYS61 4.1 33.1 1.0
CA A:VAL65 4.1 23.2 1.0
N A:LEU62 4.2 28.6 1.0
N A:PRO63 4.2 27.5 1.0
CA A:LYS60 4.3 27.7 1.0
N A:LYS61 4.4 27.6 1.0
CA A:LEU62 4.5 26.8 1.0
C A:PRO63 4.5 26.5 1.0
N A:GLY66 4.5 26.1 1.0
CA A:LYS61 4.5 27.8 1.0
CB A:VAL65 4.6 23.2 1.0
O3' D:DT2 4.6 29.3 1.0
CG A:LYS60 4.6 34.4 1.0
C A:GLY64 4.7 24.6 1.0
CA A:GLY66 4.8 25.1 1.0
O5' D:DC3 4.8 35.8 1.0
O A:ALA59 4.9 25.3 1.0
CA A:GLY64 5.0 24.1 1.0

Sodium binding site 2 out of 2 in 4nm1

Go back to Sodium Binding Sites List in 4nm1
Sodium binding site 2 out of 2 in the Structure of Human Dna Polymerase Beta Complexed with A Nicked Dna Containing A 8BRG-C at N-1 Position and G-C at N Position


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Structure of Human Dna Polymerase Beta Complexed with A Nicked Dna Containing A 8BRG-C at N-1 Position and G-C at N Position within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na404

b:19.7
occ:1.00
O A:THR101 2.2 19.8 1.0
O P:HOH204 2.3 13.8 1.0
OP1 P:DG9 2.3 21.8 1.0
O A:ILE106 2.4 15.8 1.0
O A:VAL103 2.6 16.6 1.0
C A:THR101 3.2 19.8 1.0
P P:DG9 3.4 22.9 1.0
C A:ILE106 3.4 15.7 1.0
C A:VAL103 3.6 15.6 1.0
OP2 P:DG9 3.6 24.0 1.0
N A:ILE106 3.9 15.8 1.0
CA A:THR101 3.9 19.4 1.0
CA A:SER104 4.0 16.1 1.0
N A:GLY105 4.0 16.4 1.0
N A:VAL103 4.1 16.4 1.0
CA A:ILE106 4.2 15.4 1.0
C A:ARG102 4.2 17.2 1.0
N A:SER104 4.2 14.7 1.0
N A:ARG102 4.2 18.8 1.0
C A:SER104 4.4 15.7 1.0
N A:GLY107 4.4 15.9 1.0
O3' P:DC8 4.4 25.8 1.0
CB A:THR101 4.5 18.0 1.0
CA A:ARG102 4.5 17.4 1.0
CA A:VAL103 4.5 15.4 1.0
O5' P:DG9 4.5 24.0 1.0
CA A:GLY107 4.6 15.0 1.0
O A:ARG102 4.6 18.2 1.0
CB A:ILE106 4.6 15.7 1.0
C A:GLY105 4.7 16.3 1.0
O A:LEU100 4.9 21.4 1.0
CA A:GLY105 4.9 15.8 1.0

Reference:

M.C.Koag, K.Min, S.Lee. Structural Basis For Promutagenicity of 8-Halogenated Guanine. J.Biol.Chem. V. 289 6289 2014.
ISSN: ISSN 0021-9258
PubMed: 24425881
DOI: 10.1074/JBC.M113.537803
Page generated: Mon Oct 7 17:15:58 2024

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