Atomistry » Sodium » PDB 4mfc-4mzx » 4myq
Atomistry »
  Sodium »
    PDB 4mfc-4mzx »
      4myq »

Sodium in PDB 4myq: Selective Inhibition of the Catalytic Domain of Human Phosphodiesterase 4B with A-33

Enzymatic activity of Selective Inhibition of the Catalytic Domain of Human Phosphodiesterase 4B with A-33

All present enzymatic activity of Selective Inhibition of the Catalytic Domain of Human Phosphodiesterase 4B with A-33:
3.1.4.17;

Protein crystallography data

The structure of Selective Inhibition of the Catalytic Domain of Human Phosphodiesterase 4B with A-33, PDB code: 4myq was solved by D.Fox Iii, T.E.Edwards, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.85 / 1.90
Space group P 42
Cell size a, b, c (Å), α, β, γ (°) 99.700, 99.700, 47.020, 90.00, 90.00, 90.00
R / Rfree (%) 18.8 / 22.2

Other elements in 4myq:

The structure of Selective Inhibition of the Catalytic Domain of Human Phosphodiesterase 4B with A-33 also contains other interesting chemical elements:

Magnesium (Mg) 1 atom
Zinc (Zn) 1 atom
Chlorine (Cl) 1 atom

Sodium Binding Sites:

The binding sites of Sodium atom in the Selective Inhibition of the Catalytic Domain of Human Phosphodiesterase 4B with A-33 (pdb code 4myq). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Selective Inhibition of the Catalytic Domain of Human Phosphodiesterase 4B with A-33, PDB code: 4myq:

Sodium binding site 1 out of 1 in 4myq

Go back to Sodium Binding Sites List in 4myq
Sodium binding site 1 out of 1 in the Selective Inhibition of the Catalytic Domain of Human Phosphodiesterase 4B with A-33


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Selective Inhibition of the Catalytic Domain of Human Phosphodiesterase 4B with A-33 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na704

b:23.6
occ:1.00
O A:HOH1040 2.4 25.8 1.0
O A:HOH1041 2.5 27.4 1.0
O A:HOH1043 2.6 33.2 1.0
O A:TYR399 2.6 10.6 1.0
O A:HOH871 2.7 17.5 1.0
O A:ASP397 3.1 9.2 1.0
OG A:SER401 3.2 24.0 1.0
C A:ASP397 3.8 9.5 1.0
C A:TYR399 3.8 10.3 1.0
N A:SER401 3.9 15.3 1.0
O A:GLU396 4.0 8.5 1.0
CA A:ASP397 4.0 9.8 1.0
O A:HOH1042 4.0 45.9 1.0
CB A:SER401 4.3 19.5 1.0
O A:HOH831 4.4 9.3 1.0
CA A:HIS400 4.4 13.3 1.0
C A:HIS400 4.6 13.9 1.0
N A:HIS400 4.6 11.5 1.0
CA A:SER401 4.7 17.3 1.0
N A:TYR399 4.7 9.0 1.0
C A:GLU396 4.8 9.0 1.0
CA A:TYR399 4.9 9.2 1.0
N A:HIS398 4.9 8.8 1.0
N A:ASP397 4.9 9.5 1.0
CB A:ASP397 5.0 10.6 1.0

Reference:

D.Fox, A.B.Burgin, M.E.Gurney. Structural Basis For the Design of Selective Phosphodiesterase 4B Inhibitors. Cell Signal V. 26 657 2014.
PubMed: 24361374
DOI: 10.1016/J.CELLSIG.2013.12.003
Page generated: Mon Oct 7 17:05:30 2024

Last articles

Cl in 5HXM
Cl in 5HXU
Cl in 5HXB
Cl in 5HWL
Cl in 5HXE
Cl in 5HVY
Cl in 5HWX
Cl in 5HVP
Cl in 5HSV
Cl in 5HVN
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy