Sodium in PDB 4hur: Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus in Complex with Acetyl Coenzyme A

The structure of Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus in Complex with Acetyl Coenzyme A, PDB code: 4hur was solved by P.J.Stogios, G.Minasov, E.Evdokimova, Z.Wawrzak, V.Yim, M.Krishnamoorthy, R.Di Leo, P.Courvalin, A.Savchenko, W.F.Anderson, Center For Structuralgenomics Of Infectious Diseases (Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.18 / 2.15
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	92.910, 184.545, 98.997, 90.00, 90.00, 90.00
R / Rfree (%)	16.7 / 20.2

The structure of Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus in Complex with Acetyl Coenzyme A also contains other interesting chemical elements:

Chlorine

(Cl)

2 atoms

The binding sites of Sodium atom in the Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus in Complex with Acetyl Coenzyme A (pdb code 4hur). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus in Complex with Acetyl Coenzyme A, PDB code: 4hur:

Sodium binding site 1 out of 1 in the Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus in Complex with Acetyl Coenzyme A


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of Streptogramin Group A Antibiotic Acetyltransferase Vata From Staphylococcus Aureus in Complex with Acetyl Coenzyme A within 5.0Å range: probe atom residue distance (Å) B Occ A:Na316 b:36.0 occ:1.00 O B:HOH502 2.4 35.7 1.0 O A:HOH426 2.4 38.8 1.0 O A:ASN164 2.4 35.2 1.0 O C:HOH422 2.5 32.5 1.0 O C:ASN164 2.5 34.1 1.0 O B:ASN164 2.5 32.8 1.0 C A:ASN164 3.2 33.8 1.0 C B:ASN164 3.3 33.8 1.0 C C:ASN164 3.3 34.4 1.0 N A:PRO165 3.9 38.3 1.0 CD C:PRO165 3.9 39.2 1.0 CD A:PRO165 3.9 37.0 1.0 N B:PRO165 3.9 37.6 1.0 CD B:PRO165 3.9 39.6 1.0 N A:ASN164 4.0 31.8 1.0 N C:PRO165 4.0 36.5 1.0 N B:ASN164 4.0 34.5 1.0 N C:ASN164 4.0 32.8 1.0 CA A:ASN164 4.2 31.6 1.0 O B:HOH574 4.2 86.7 1.0 CA B:ASN164 4.2 33.0 1.0 CA C:ASN164 4.3 31.6 1.0 O A:PRO165 4.6 39.3 1.0 O B:PRO165 4.7 39.5 1.0 O C:PRO165 4.7 35.3 1.0 CB A:ASN164 4.8 32.5 1.0 CB B:ASN164 4.9 34.5 1.0 CB C:ASN164 4.9 34.0 1.0

P.J.Stogios, M.L.Kuhn, E.Evdokimova, P.Courvalin, W.F.Anderson, A.Savchenko. Potential For Reduction of Streptogramin A Resistance Revealed By Structural Analysis of Acetyltransferase Vata. Antimicrob.Agents Chemother. V. 58 7083 2014.
ISSN: ISSN 0066-4804
PubMed: 25223995
DOI: 10.1128/AAC.03743-14