Sodium in PDB 3zyv: Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3)
Enzymatic activity of Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3)
All present enzymatic activity of Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3):
1.2.3.1;
Protein crystallography data
The structure of Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3), PDB code: 3zyv
was solved by
J.Trincao,
C.Coelho,
M.Mahro,
D.Rodrigues,
M.Terao,
E.Garattini,
S.Leimkuehler,
M.J.Romao,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
49.906 /
2.54
|
Space group
|
P 1
|
Cell size a, b, c (Å), α, β, γ (°)
|
90.880,
135.270,
147.370,
78.16,
77.72,
89.90
|
R / Rfree (%)
|
25.55 /
28.5
|
Other elements in 3zyv:
The structure of Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3) also contains other interesting chemical elements:
Sodium Binding Sites:
The binding sites of Sodium atom in the Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3)
(pdb code 3zyv). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total 4 binding sites of Sodium where determined in the
Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3), PDB code: 3zyv:
Jump to Sodium binding site number:
1;
2;
3;
4;
Sodium binding site 1 out
of 4 in 3zyv
Go back to
Sodium Binding Sites List in 3zyv
Sodium binding site 1 out
of 4 in the Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3)
Mono view
Stereo pair view
|
A full contact list of Sodium with other atoms in the Na binding
site number 1 of Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Na2337
b:26.4
occ:1.00
|
O
|
A:THR875
|
2.3
|
39.4
|
1.0
|
OG
|
A:SER879
|
2.4
|
48.1
|
1.0
|
O
|
A:GLY872
|
2.7
|
39.5
|
1.0
|
O
|
A:PRO876
|
2.7
|
41.4
|
1.0
|
O
|
A:ASN913
|
3.0
|
40.1
|
1.0
|
C
|
A:PRO876
|
3.3
|
42.1
|
1.0
|
OG
|
A:SER912
|
3.4
|
35.6
|
1.0
|
C
|
A:THR875
|
3.5
|
39.1
|
1.0
|
CB
|
A:SER879
|
3.5
|
43.1
|
1.0
|
C
|
A:GLY872
|
3.6
|
37.4
|
1.0
|
CB
|
A:ASP877
|
3.6
|
37.2
|
1.0
|
N
|
A:ASN913
|
3.9
|
24.2
|
1.0
|
CA
|
A:PRO876
|
4.0
|
38.2
|
1.0
|
N
|
A:ASP877
|
4.0
|
42.2
|
1.0
|
CA
|
A:GLY872
|
4.1
|
35.5
|
1.0
|
C
|
A:ASN913
|
4.1
|
38.0
|
1.0
|
N
|
A:PRO876
|
4.2
|
37.0
|
1.0
|
NE2
|
A:HIS845
|
4.3
|
36.0
|
1.0
|
N
|
A:SER879
|
4.3
|
41.1
|
1.0
|
CA
|
A:ASP877
|
4.3
|
41.6
|
1.0
|
CA
|
A:ASN913
|
4.4
|
19.6
|
1.0
|
CA
|
A:SER879
|
4.4
|
47.1
|
1.0
|
C
|
A:SER912
|
4.5
|
33.9
|
1.0
|
CB
|
A:SER912
|
4.5
|
33.0
|
1.0
|
CA
|
A:SER912
|
4.6
|
31.1
|
1.0
|
N
|
A:THR875
|
4.7
|
36.3
|
1.0
|
CA
|
A:THR875
|
4.7
|
35.4
|
1.0
|
N
|
A:GLY873
|
4.7
|
37.4
|
1.0
|
OG1
|
A:THR875
|
4.7
|
39.9
|
1.0
|
CD1
|
A:ILE713
|
4.7
|
46.4
|
1.0
|
C
|
A:ASP877
|
4.8
|
42.9
|
1.0
|
CB
|
A:ASN913
|
4.8
|
24.1
|
1.0
|
CE1
|
A:HIS845
|
4.9
|
36.1
|
1.0
|
CG
|
A:ASP877
|
4.9
|
41.6
|
1.0
|
N
|
A:ASP878
|
4.9
|
41.0
|
1.0
|
|
Sodium binding site 2 out
of 4 in 3zyv
Go back to
Sodium Binding Sites List in 3zyv
Sodium binding site 2 out
of 4 in the Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3)
Mono view
Stereo pair view
|
A full contact list of Sodium with other atoms in the Na binding
site number 2 of Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Na2337
b:13.0
occ:1.00
|
O
|
B:THR875
|
2.4
|
39.7
|
1.0
|
OG
|
B:SER879
|
2.5
|
47.2
|
1.0
|
O
|
B:GLY872
|
2.7
|
39.4
|
1.0
|
O
|
B:PRO876
|
2.8
|
40.3
|
1.0
|
O
|
B:ASN913
|
2.9
|
39.6
|
1.0
|
O
|
B:HOH2124
|
2.9
|
40.8
|
1.0
|
OG
|
B:SER912
|
3.2
|
36.8
|
1.0
|
C
|
B:PRO876
|
3.4
|
41.1
|
1.0
|
CB
|
B:ASP877
|
3.5
|
36.5
|
1.0
|
C
|
B:THR875
|
3.6
|
39.6
|
1.0
|
C
|
B:GLY872
|
3.7
|
37.9
|
1.0
|
CB
|
B:SER879
|
3.7
|
42.6
|
1.0
|
N
|
B:ASN913
|
3.8
|
25.5
|
1.0
|
C
|
B:ASN913
|
3.9
|
36.7
|
1.0
|
N
|
B:ASP877
|
4.0
|
41.8
|
1.0
|
CA
|
B:PRO876
|
4.1
|
38.6
|
1.0
|
CA
|
B:GLY872
|
4.2
|
35.6
|
1.0
|
CA
|
B:ASN913
|
4.3
|
20.2
|
1.0
|
CA
|
B:ASP877
|
4.3
|
40.9
|
1.0
|
NE2
|
B:HIS845
|
4.3
|
35.6
|
1.0
|
N
|
B:PRO876
|
4.3
|
37.2
|
1.0
|
C
|
B:SER912
|
4.3
|
33.9
|
1.0
|
N
|
B:SER879
|
4.4
|
40.9
|
1.0
|
CB
|
B:SER912
|
4.4
|
33.0
|
1.0
|
CA
|
B:SER912
|
4.5
|
30.7
|
1.0
|
CA
|
B:SER879
|
4.5
|
46.7
|
1.0
|
OG1
|
B:THR875
|
4.6
|
41.3
|
1.0
|
CB
|
B:ASN913
|
4.7
|
25.1
|
1.0
|
CG
|
B:ASP877
|
4.7
|
40.8
|
1.0
|
N
|
B:THR875
|
4.7
|
36.0
|
1.0
|
CA
|
B:THR875
|
4.7
|
34.5
|
1.0
|
N
|
B:GLY873
|
4.8
|
38.1
|
1.0
|
C
|
B:ASP877
|
4.8
|
42.5
|
1.0
|
N
|
B:ASP878
|
4.8
|
41.4
|
1.0
|
CE1
|
B:HIS845
|
4.9
|
36.4
|
1.0
|
CD1
|
B:ILE713
|
4.9
|
46.3
|
1.0
|
|
Sodium binding site 3 out
of 4 in 3zyv
Go back to
Sodium Binding Sites List in 3zyv
Sodium binding site 3 out
of 4 in the Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3)
Mono view
Stereo pair view
|
A full contact list of Sodium with other atoms in the Na binding
site number 3 of Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Na2337
b:50.8
occ:1.00
|
O
|
C:THR875
|
2.3
|
41.6
|
1.0
|
O
|
C:GLY872
|
2.5
|
42.0
|
1.0
|
OG
|
C:SER912
|
2.6
|
38.0
|
1.0
|
O
|
C:ASN913
|
2.7
|
42.0
|
1.0
|
OG
|
C:SER879
|
3.2
|
47.6
|
1.0
|
N
|
C:ASN913
|
3.3
|
38.4
|
1.0
|
O
|
C:PRO876
|
3.4
|
41.8
|
1.0
|
C
|
C:THR875
|
3.5
|
41.5
|
1.0
|
CB
|
C:ASP877
|
3.6
|
37.9
|
1.0
|
C
|
C:GLY872
|
3.6
|
43.4
|
1.0
|
C
|
C:ASN913
|
3.7
|
39.5
|
1.0
|
CB
|
C:SER912
|
3.7
|
37.3
|
1.0
|
C
|
C:SER912
|
3.7
|
37.3
|
1.0
|
C
|
C:PRO876
|
3.7
|
42.4
|
1.0
|
CA
|
C:SER912
|
3.8
|
37.8
|
1.0
|
CA
|
C:ASN913
|
3.9
|
38.1
|
1.0
|
N
|
C:ASP877
|
4.2
|
42.1
|
1.0
|
OG1
|
C:THR875
|
4.2
|
40.8
|
1.0
|
CA
|
C:GLY872
|
4.3
|
44.6
|
1.0
|
CB
|
C:SER879
|
4.4
|
44.2
|
1.0
|
N
|
C:THR875
|
4.4
|
41.6
|
1.0
|
N
|
C:PRO876
|
4.4
|
42.0
|
1.0
|
CA
|
C:PRO876
|
4.4
|
42.6
|
1.0
|
CA
|
C:ASP877
|
4.5
|
40.9
|
1.0
|
CA
|
C:THR875
|
4.5
|
41.3
|
1.0
|
CB
|
C:ASN913
|
4.5
|
39.5
|
1.0
|
O
|
C:SER912
|
4.5
|
39.1
|
1.0
|
N
|
C:GLY873
|
4.6
|
44.0
|
1.0
|
NE2
|
C:HIS845
|
4.6
|
42.1
|
1.0
|
CG
|
C:ASP877
|
4.7
|
42.1
|
1.0
|
CA
|
C:GLY873
|
4.7
|
43.0
|
1.0
|
O
|
C:HOH2087
|
4.8
|
31.9
|
1.0
|
N
|
C:THR914
|
4.9
|
42.8
|
1.0
|
C
|
C:GLY873
|
5.0
|
43.8
|
1.0
|
N
|
C:SER879
|
5.0
|
42.2
|
1.0
|
|
Sodium binding site 4 out
of 4 in 3zyv
Go back to
Sodium Binding Sites List in 3zyv
Sodium binding site 4 out
of 4 in the Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3)
Mono view
Stereo pair view
|
A full contact list of Sodium with other atoms in the Na binding
site number 4 of Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Na2337
b:17.8
occ:1.00
|
O
|
D:THR875
|
2.4
|
44.1
|
1.0
|
O
|
D:GLY872
|
2.5
|
44.9
|
1.0
|
O
|
D:ASN913
|
2.6
|
42.2
|
1.0
|
OG
|
D:SER912
|
2.7
|
41.4
|
1.0
|
OG
|
D:SER879
|
3.1
|
49.5
|
1.0
|
N
|
D:ASN913
|
3.3
|
42.1
|
1.0
|
O
|
D:PRO876
|
3.3
|
44.6
|
1.0
|
CB
|
D:ASP877
|
3.5
|
41.6
|
1.0
|
C
|
D:ASN913
|
3.6
|
41.9
|
1.0
|
C
|
D:GLY872
|
3.6
|
46.1
|
1.0
|
C
|
D:THR875
|
3.6
|
44.0
|
1.0
|
C
|
D:PRO876
|
3.7
|
44.1
|
1.0
|
C
|
D:SER912
|
3.8
|
41.1
|
1.0
|
CB
|
D:SER912
|
3.8
|
40.8
|
1.0
|
CA
|
D:ASN913
|
3.9
|
42.1
|
1.0
|
CA
|
D:SER912
|
3.9
|
41.3
|
1.0
|
N
|
D:ASP877
|
4.2
|
42.9
|
1.0
|
CB
|
D:SER879
|
4.3
|
46.9
|
1.0
|
CA
|
D:GLY872
|
4.3
|
47.3
|
1.0
|
OG1
|
D:THR875
|
4.3
|
41.4
|
1.0
|
CA
|
D:ASP877
|
4.4
|
42.1
|
1.0
|
CA
|
D:PRO876
|
4.4
|
45.0
|
1.0
|
CB
|
D:ASN913
|
4.4
|
43.4
|
1.0
|
N
|
D:PRO876
|
4.5
|
44.4
|
1.0
|
NE2
|
D:HIS845
|
4.5
|
45.7
|
1.0
|
N
|
D:THR875
|
4.5
|
43.9
|
1.0
|
CA
|
D:THR875
|
4.6
|
43.6
|
1.0
|
N
|
D:GLY873
|
4.6
|
46.4
|
1.0
|
O
|
D:SER912
|
4.6
|
40.0
|
1.0
|
CG
|
D:ASP877
|
4.7
|
41.6
|
1.0
|
CA
|
D:GLY873
|
4.8
|
45.5
|
1.0
|
N
|
D:SER879
|
4.8
|
45.2
|
1.0
|
N
|
D:THR914
|
4.8
|
43.0
|
1.0
|
CE1
|
D:HIS845
|
5.0
|
44.7
|
1.0
|
|
Reference:
C.Coelho,
M.Mahro,
J.Trincao,
A.T.P.Carvalho,
M.J.Ramos,
M.Terao,
E.Garattini,
S.Leimkuhler,
M.J.Romao.
The First Mammalian Aldehyde Oxidase Crystal Structure: Insights Into Substrate Specificity. J.Biol.Chem. V. 287 40690 2012.
ISSN: ISSN 0021-9258
PubMed: 23019336
DOI: 10.1074/JBC.M112.390419
Page generated: Mon Oct 7 14:15:00 2024
|