Sodium in PDB 3zqs: Human Fancl Central Domain

All present enzymatic activity of Human Fancl Central Domain:
6.3.2.19;

The structure of Human Fancl Central Domain, PDB code: 3zqs was solved by C.Hodson, A.R.Cole, A.Purkiss-Trew, H.Walden, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	44.265 / 2.00
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	147.600, 102.520, 65.760, 90.00, 94.09, 90.00
R / Rfree (%)	18.33 / 20.66

The binding sites of Sodium atom in the Human Fancl Central Domain (pdb code 3zqs). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Human Fancl Central Domain, PDB code: 3zqs:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Human Fancl Central Domain


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Human Fancl Central Domain within 5.0Å range: probe atom residue distance (Å) B Occ B:Na1295 b:27.2 occ:1.00 O B:TRP123 2.3 21.4 1.0 O A:LEU126 2.4 24.4 1.0 O A:HOH2013 2.5 24.7 1.0 O B:LEU126 2.5 25.7 1.0 O A:TRP123 2.5 19.6 1.0 C B:TRP123 3.4 24.4 1.0 C A:LEU126 3.5 32.3 1.0 C B:LEU126 3.6 27.9 1.0 C A:TRP123 3.6 27.4 1.0 CA B:ASP124 3.8 30.7 1.0 N B:LEU126 4.0 23.4 1.0 CA A:ASP124 4.0 30.0 1.0 C B:ASP124 4.0 27.3 1.0 N B:ASP124 4.0 22.7 1.0 N A:LEU126 4.0 23.7 1.0 C A:ASP124 4.1 24.1 1.0 O B:ASP124 4.1 28.2 1.0 O A:ASP124 4.1 26.0 1.0 CA A:LEU126 4.2 21.9 1.0 CA B:LEU126 4.2 19.6 1.0 N A:ASP124 4.2 23.4 1.0 CB B:LEU126 4.3 19.0 1.0 CB A:LEU126 4.3 19.6 1.0 CA B:TRP123 4.5 20.0 1.0 N A:VAL127 4.5 20.5 1.0 CA A:VAL127 4.6 21.7 1.0 N B:VAL127 4.7 21.7 1.0 N B:LYS125 4.7 24.5 1.0 CB B:TRP123 4.7 20.4 1.0 CA A:TRP123 4.7 19.1 1.0 N A:LYS125 4.7 22.2 1.0 CA B:VAL127 4.8 22.3 1.0 C B:LYS125 4.9 29.7 1.0 CB A:TRP123 4.9 21.2 1.0 C A:LYS125 4.9 21.2 1.0 CG B:LEU126 5.0 23.1 1.0

Sodium binding site 2 out of 2 in the Human Fancl Central Domain


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Human Fancl Central Domain within 5.0Å range: probe atom residue distance (Å) B Occ B:Na1296 b:42.9 occ:1.00 O B:TRP274 2.6 35.9 1.0 O B:HIS272 2.6 27.8 1.0 C B:HIS272 3.4 26.4 1.0 C B:TRP274 3.6 44.5 1.0 N B:TRP274 3.8 33.1 1.0 CA B:HIS272 4.0 25.4 1.0 C B:LEU273 4.1 39.1 1.0 CA B:TRP274 4.2 31.0 1.0 O B:ILE271 4.2 30.1 1.0 N B:LEU273 4.4 26.5 1.0 O B:LEU273 4.5 33.5 1.0 CA B:LEU273 4.6 28.5 1.0 CB B:TRP274 4.6 31.2 1.0 N B:ASP275 4.7 40.1 1.0 CA B:ASP275 5.0 43.4 1.0

C.Hodson, A.R.Cole, L.P.Lewis, J.A.Miles, A.Purkiss-Trew, H.Walden. Structural Analysis of Human Fancl, the E3 Ligase in the Fanconi Anemia Pathway. J.Biol.Chem. V. 286 32628 2011.
ISSN: ISSN 0021-9258
PubMed: 21775430
DOI: 10.1074/JBC.M111.244632