Sodium in PDB 3mbg: Crystal Structure of Human Augmenter of Liver Regeneration (Alr)

All present enzymatic activity of Crystal Structure of Human Augmenter of Liver Regeneration (Alr):
1.8.3.2;

The structure of Crystal Structure of Human Augmenter of Liver Regeneration (Alr), PDB code: 3mbg was solved by M.Dong, S.Schaefer, V.N.Daithankar, C.Thorpe, B.J.Bahnson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	27.76 / 1.85
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	112.719, 65.145, 63.767, 90.00, 89.97, 90.00
R / Rfree (%)	18.9 / 23.1

The structure of Crystal Structure of Human Augmenter of Liver Regeneration (Alr) also contains other interesting chemical elements:

Zinc

(Zn)

10 atoms

The binding sites of Sodium atom in the Crystal Structure of Human Augmenter of Liver Regeneration (Alr) (pdb code 3mbg). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 4 binding sites of Sodium where determined in the Crystal Structure of Human Augmenter of Liver Regeneration (Alr), PDB code: 3mbg:
Jump to Sodium binding site number: 1; 2; 3; 4;

Sodium binding site 1 out of 4 in the Crystal Structure of Human Augmenter of Liver Regeneration (Alr)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of Human Augmenter of Liver Regeneration (Alr) within 5.0Å range: probe atom residue distance (Å) B Occ A:Na9 b:33.6 occ:1.00 OD2 A:ASP98 2.2 33.3 1.0 CG A:ASP98 2.9 28.1 1.0 OD1 A:ASP98 3.0 27.0 1.0 O A:HOH12 4.0 24.6 1.0 O B:HOH244 4.3 52.0 1.0 CB A:ASP98 4.3 25.5 1.0 CB A:GLU100 4.4 21.8 1.0 CG A:GLU100 4.7 24.1 1.0

Sodium binding site 2 out of 4 in the Crystal Structure of Human Augmenter of Liver Regeneration (Alr)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Crystal Structure of Human Augmenter of Liver Regeneration (Alr) within 5.0Å range: probe atom residue distance (Å) B Occ B:Na7 b:33.6 occ:1.00 OD2 B:ASP98 2.0 32.5 1.0 CG B:ASP98 2.9 28.6 1.0 OD1 B:ASP98 3.0 26.9 1.0 O B:HOH260 4.0 25.1 1.0 CB B:ASP98 4.3 25.9 1.0 CB B:GLU100 4.4 21.6 1.0 CG B:GLU100 4.7 24.4 1.0

Sodium binding site 3 out of 4 in the Crystal Structure of Human Augmenter of Liver Regeneration (Alr)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of Crystal Structure of Human Augmenter of Liver Regeneration (Alr) within 5.0Å range: probe atom residue distance (Å) B Occ C:Na8 b:32.0 occ:1.00 OD2 C:ASP98 2.0 32.3 1.0 O C:HOH432 2.1 46.5 1.0 CG C:ASP98 2.9 28.3 1.0 OD1 C:ASP98 3.0 26.2 1.0 O C:HOH296 4.0 25.3 1.0 CB C:ASP98 4.3 25.6 1.0 CB C:GLU100 4.4 22.0 1.0 CG C:GLU100 4.7 24.5 1.0

Sodium binding site 4 out of 4 in the Crystal Structure of Human Augmenter of Liver Regeneration (Alr)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 4 of Crystal Structure of Human Augmenter of Liver Regeneration (Alr) within 5.0Å range: probe atom residue distance (Å) B Occ C:Na206 b:45.7 occ:1.00 OD1 C:ASP128 2.3 28.0 1.0 O B:HOH210 2.7 46.1 1.0 CG C:ASP128 3.0 27.3 1.0 OD2 C:ASP128 3.0 27.8 1.0 NZ B:LYS138 3.2 36.0 1.0 O C:HOH400 3.3 45.5 1.0 OE2 C:GLU124 3.3 41.8 1.0 O C:HOH392 3.7 37.8 1.0 CG C:GLU124 4.0 35.5 1.0 CD C:GLU124 4.1 40.8 1.0 NE2 B:GLN131 4.2 38.2 1.0 CE B:LYS138 4.4 35.6 1.0 CB C:ASP128 4.5 23.7 1.0 O B:HOH242 4.5 59.5 1.0 CD2 B:LEU135 4.5 24.6 1.0 O B:HOH269 4.6 50.2 1.0 O C:GLU124 5.0 29.0 1.0

V.N.Daithankar, S.A.Schaefer, M.Dong, B.J.Bahnson, C.Thorpe. Structure of the Human Sulfhydryl Oxidase Augmenter of Liver Regeneration and Characterization of A Human Mutation Causing An Autosomal Recessive Myopathy . Biochemistry V. 49 6737 2010.
ISSN: ISSN 0006-2960
PubMed: 20593814
DOI: 10.1021/BI100912M