Sodium in PDB 3fr0: Human Glucokinase in Complex with 2-Amino Benzamide Activator

All present enzymatic activity of Human Glucokinase in Complex with 2-Amino Benzamide Activator:
2.7.1.2;

The structure of Human Glucokinase in Complex with 2-Amino Benzamide Activator, PDB code: 3fr0 was solved by K.Kamata, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.07 / 2.70
Space group	P 65 2 2
Cell size a, b, c (Å), α, β, γ (°)	80.147, 80.147, 323.170, 90.00, 90.00, 120.00
R / Rfree (%)	22.2 / 28.2

The binding sites of Sodium atom in the Human Glucokinase in Complex with 2-Amino Benzamide Activator (pdb code 3fr0). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Human Glucokinase in Complex with 2-Amino Benzamide Activator, PDB code: 3fr0:

Sodium binding site 1 out of 1 in the Human Glucokinase in Complex with 2-Amino Benzamide Activator


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Human Glucokinase in Complex with 2-Amino Benzamide Activator within 5.0Å range: probe atom residue distance (Å) B Occ A:Na801 b:33.5 occ:1.00 O A:VAL244 2.6 39.8 1.0 O A:MET238 2.6 35.7 1.0 O A:GLY246 2.7 49.8 1.0 O A:VAL241 2.8 39.8 1.0 C A:GLY246 3.4 48.8 1.0 N A:GLY246 3.5 42.9 1.0 C A:MET238 3.6 36.3 1.0 C A:VAL241 3.7 38.0 1.0 C A:VAL244 3.7 39.9 1.0 OD2 A:ASP247 3.9 62.3 1.0 C A:GLU245 3.9 42.7 1.0 CE A:MET238 4.0 41.7 1.0 CA A:GLY246 4.0 46.2 1.0 CA A:GLN239 4.0 35.6 1.0 N A:GLN239 4.2 34.7 1.0 CA A:GLU245 4.2 43.2 1.0 N A:ASP247 4.2 51.3 1.0 C A:GLN239 4.3 35.6 1.0 CA A:GLU242 4.4 37.2 1.0 N A:GLU245 4.4 41.9 1.0 N A:GLU242 4.4 37.4 1.0 CA A:ASP247 4.5 54.2 1.0 CA A:VAL241 4.5 37.1 1.0 N A:VAL241 4.5 36.2 1.0 O A:GLN239 4.5 35.7 1.0 CA A:MET238 4.6 36.5 1.0 CB A:VAL241 4.6 36.3 1.0 O A:GLU245 4.6 42.4 1.0 CB A:MET238 4.8 37.2 1.0 CA A:VAL244 4.8 38.9 1.0 C A:GLU242 4.9 37.8 1.0 N A:VAL244 4.9 39.4 1.0 CG A:ASP247 5.0 60.3 1.0 N A:ASN240 5.0 35.6 1.0

T.Nishimura, T.Iino, M.Mitsuya, M.Bamba, H.Watanabe, D.Tsukahara, K.Kamata, K.Sasaki, S.Ohyama, H.Hosaka, M.Futamura, Y.Nagata, J.Eiki. Identification of Novel and Potent 2-Amino Benzamide Derivatives As Allosteric Glucokinase Activators Bioorg.Med.Chem.Lett. V. 19 1357 2009.
ISSN: ISSN 0960-894X
PubMed: 19188063
DOI: 10.1016/J.BMCL.2009.01.053