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Sodium in PDB 3eqd: X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with Atp-Gs and MG2P

Enzymatic activity of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with Atp-Gs and MG2P

All present enzymatic activity of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with Atp-Gs and MG2P:
2.7.12.2;

Protein crystallography data

The structure of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with Atp-Gs and MG2P, PDB code: 3eqd was solved by T.O.Fischmann, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.00 / 2.10
Space group P 61 2 2
Cell size a, b, c (Å), α, β, γ (°) 77.010, 77.010, 222.370, 90.00, 90.00, 120.00
R / Rfree (%) n/a / n/a

Other elements in 3eqd:

The structure of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with Atp-Gs and MG2P also contains other interesting chemical elements:

Magnesium (Mg) 1 atom
Calcium (Ca) 1 atom

Sodium Binding Sites:

The binding sites of Sodium atom in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with Atp-Gs and MG2P (pdb code 3eqd). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with Atp-Gs and MG2P, PDB code: 3eqd:

Sodium binding site 1 out of 1 in 3eqd

Go back to Sodium Binding Sites List in 3eqd
Sodium binding site 1 out of 1 in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with Atp-Gs and MG2P


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Binary Complex with Atp-Gs and MG2P within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na6

b:38.3
occ:1.00
O A:HOH414 2.2 53.2 1.0
O A:HOH441 2.3 47.8 1.0
O A:HOH471 2.4 61.4 1.0
OD2 A:ASP65 2.4 52.3 1.0
O A:HOH470 2.4 52.2 1.0
OD1 A:ASP65 2.5 49.6 1.0
CG A:ASP65 2.8 50.4 1.0
CA A:CA5 4.3 50.1 0.5
CB A:ASP65 4.3 45.1 1.0
OE2 A:GLU138 4.4 83.0 1.0
NH2 A:ARG96 4.4 41.2 1.0
NH1 A:ARG96 4.5 39.1 1.0
O A:ASP65 4.7 46.3 1.0
CZ A:ARG96 5.0 56.8 1.0

Reference:

T.O.Fischmann, C.K.Smith, T.W.Mayhood, J.E.Myers, P.Reichert, A.Mannarino, D.Carr, H.Zhu, J.Wong, R.S.Yang, H.V.Le, V.S.Madison. Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry V. 48 2661 2009.
ISSN: ISSN 0006-2960
PubMed: 19161339
DOI: 10.1021/BI801898E
Page generated: Tue Dec 15 06:10:04 2020

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