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Sodium in PDB 3dkk: Aged Form of Human Butyrylcholinesterase Inhibited By Tabun

Enzymatic activity of Aged Form of Human Butyrylcholinesterase Inhibited By Tabun

All present enzymatic activity of Aged Form of Human Butyrylcholinesterase Inhibited By Tabun:
3.1.1.8;

Protein crystallography data

The structure of Aged Form of Human Butyrylcholinesterase Inhibited By Tabun, PDB code: 3dkk was solved by F.Nachon, E.Carletti, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 28.18 / 2.31
Space group I 4 2 2
Cell size a, b, c (Å), α, β, γ (°) 155.240, 155.240, 127.470, 90.00, 90.00, 90.00
R / Rfree (%) 19.7 / 25.1

Other elements in 3dkk:

The structure of Aged Form of Human Butyrylcholinesterase Inhibited By Tabun also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Aged Form of Human Butyrylcholinesterase Inhibited By Tabun (pdb code 3dkk). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Aged Form of Human Butyrylcholinesterase Inhibited By Tabun, PDB code: 3dkk:

Sodium binding site 1 out of 1 in 3dkk

Go back to Sodium Binding Sites List in 3dkk
Sodium binding site 1 out of 1 in the Aged Form of Human Butyrylcholinesterase Inhibited By Tabun


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Aged Form of Human Butyrylcholinesterase Inhibited By Tabun within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na543

b:57.9
occ:0.50
CZ A:PHE525 3.3 53.9 1.0
CE2 A:PHE525 3.4 52.5 1.0
CE1 A:PHE525 3.7 52.7 1.0
CD2 A:PHE525 3.8 51.7 1.0
CD1 A:PHE525 4.1 52.9 1.0
CG A:PHE525 4.1 49.7 1.0
CE1 A:HIS372 4.1 34.6 0.5
CZ A:PHE364 4.7 27.9 1.0
CB A:SER368 4.9 32.0 1.0
NE2 A:HIS372 5.0 34.3 0.5

Reference:

E.Carletti, H.Li, B.Li, F.Ekstrom, Y.Nicolet, M.Loiodice, E.Gillon, M.T.Froment, O.Lockridge, L.M.Schopfer, P.Masson, F.Nachon. Aging of Cholinesterases Phosphylated By Tabun Proceeds Through O-Dealkylation. J.Am.Chem.Soc. V. 130 16011 2008.
ISSN: ISSN 0002-7863
PubMed: 18975951
DOI: 10.1021/JA804941Z
Page generated: Mon Oct 7 08:35:31 2024

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