Sodium in PDB 2wxy: Crystal Structure of Mouse Angiotensinogen in the Reduced Form

The structure of Crystal Structure of Mouse Angiotensinogen in the Reduced Form, PDB code: 2wxy was solved by A.Zhou, Z.Wei, R.W.Carrell, R.J.Read, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.00 / 2.10
Space group	P 61 2 2
Cell size a, b, c (Å), α, β, γ (°)	64.794, 64.794, 463.197, 90.00, 90.00, 120.00
R / Rfree (%)	21.877 / 24.215

The binding sites of Sodium atom in the Crystal Structure of Mouse Angiotensinogen in the Reduced Form (pdb code 2wxy). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 4 binding sites of Sodium where determined in the Crystal Structure of Mouse Angiotensinogen in the Reduced Form, PDB code: 2wxy:
Jump to Sodium binding site number: 1; 2; 3; 4;

Sodium binding site 1 out of 4 in the Crystal Structure of Mouse Angiotensinogen in the Reduced Form


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of Mouse Angiotensinogen in the Reduced Form within 5.0Å range: probe atom residue distance (Å) B Occ C:Na1451 b:60.6 occ:1.00 OE2 C:GLU65 3.2 69.5 1.0 O C:HIS9 3.7 44.3 1.0 ND1 C:HIS9 3.7 52.1 1.0 NH2 C:ARG69 3.7 60.1 1.0 CD C:GLU65 3.8 70.0 1.0 CE1 C:HIS13 3.9 54.0 1.0 OE1 C:GLU65 3.9 72.1 1.0 CA C:HIS9 4.0 43.6 1.0 NE C:ARG69 4.0 55.2 1.0 CB C:HIS9 4.1 44.1 1.0 C C:HIS9 4.3 42.5 1.0 CZ C:ARG69 4.3 57.5 1.0 ND1 C:HIS13 4.4 58.6 1.0 CG C:HIS9 4.4 46.4 1.0 NZ C:LYS145 4.5 53.5 1.0 CE1 C:HIS9 4.8 52.7 1.0

Sodium binding site 2 out of 4 in the Crystal Structure of Mouse Angiotensinogen in the Reduced Form


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Crystal Structure of Mouse Angiotensinogen in the Reduced Form within 5.0Å range: probe atom residue distance (Å) B Occ C:Na1454 b:66.8 occ:1.00 OE1 C:GLU31 2.3 48.0 0.1 CD C:GLU31 3.2 48.6 1.0 OE2 C:GLU31 3.7 46.5 1.0 O C:HOH2002 3.7 28.3 1.0 OG C:SER32 4.1 38.3 0.5 N C:SER32 4.2 39.6 1.0 CG C:GLU31 4.2 47.1 1.0 ND1 C:HIS187 4.3 41.2 1.0 CA C:GLU31 4.6 44.1 1.0 CB C:SER188 4.7 37.5 1.0 CB C:HIS187 4.8 36.6 1.0 CB C:SER32 4.9 39.0 0.5 N C:SER188 4.9 35.9 1.0 CB C:SER32 4.9 39.2 0.5 OG C:SER32 4.9 38.6 0.5 CB C:GLU31 4.9 43.9 1.0 C C:GLU31 4.9 41.8 1.0

Sodium binding site 3 out of 4 in the Crystal Structure of Mouse Angiotensinogen in the Reduced Form


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of Crystal Structure of Mouse Angiotensinogen in the Reduced Form within 5.0Å range: probe atom residue distance (Å) B Occ C:Na1458 b:60.1 occ:1.00 OH C:TYR12 2.6 66.8 1.0 N C:GLY143 3.1 39.8 1.0 O1 C:EDO1453 3.1 62.0 1.0 CZ C:TYR12 3.5 65.8 1.0 O C:LEU141 3.7 41.3 1.0 CD2 C:LEU114 3.7 33.8 1.0 CE2 C:TYR12 3.7 61.7 1.0 C1 C:EDO1453 3.7 61.3 1.0 CE2 C:TYR113 3.8 35.4 1.0 CA C:GLY143 3.9 38.4 1.0 CA C:ASP142 4.0 41.9 1.0 C C:ASP142 4.0 40.5 1.0 CD2 C:TYR113 4.4 33.7 1.0 OD2 C:ASP142 4.5 45.0 1.0 C C:LEU141 4.6 42.4 1.0 CZ C:TYR113 4.6 36.3 1.0 OH C:TYR113 4.6 38.5 1.0 CE1 C:TYR12 4.7 67.2 1.0 CG C:LEU114 4.7 32.8 1.0 N C:HIS144 4.8 39.9 1.0 N C:ASP142 4.8 42.3 1.0 C C:GLY143 4.9 38.6 1.0

Sodium binding site 4 out of 4 in the Crystal Structure of Mouse Angiotensinogen in the Reduced Form


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 4 of Crystal Structure of Mouse Angiotensinogen in the Reduced Form within 5.0Å range: probe atom residue distance (Å) B Occ C:Na1459 b:62.7 occ:1.00 O C:HOH2015 3.3 19.7 1.0 NE2 C:HIS9 3.9 50.1 1.0 CD2 C:HIS9 4.2 46.2 1.0 NE2 C:GLN72 4.3 48.6 1.0

A.Zhou, R.W.Carrell, M.P.Murphy, Z.Wei, Y.Yan, P.L.Stanley, P.E.Stein, F.B.Pipkin, R.J.Read. A Redox Switch in Angiotensinogen Modulates Angiotensin Release. Nature V. 468 108 2010.
ISSN: ISSN 0028-0836
PubMed: 20927107
DOI: 10.1038/NATURE09505