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Sodium in PDB 2wb5: Glcnacstatins Are Nanomolar Inhibitors of Human O-Glcnacase Inducing Cellular Hyper-O-Glcnacylation

Enzymatic activity of Glcnacstatins Are Nanomolar Inhibitors of Human O-Glcnacase Inducing Cellular Hyper-O-Glcnacylation

All present enzymatic activity of Glcnacstatins Are Nanomolar Inhibitors of Human O-Glcnacase Inducing Cellular Hyper-O-Glcnacylation:
3.2.1.35; 3.2.1.52;

Protein crystallography data

The structure of Glcnacstatins Are Nanomolar Inhibitors of Human O-Glcnacase Inducing Cellular Hyper-O-Glcnacylation, PDB code: 2wb5 was solved by H.C.Dorfmueller, V.S.Borodkin, M.Schimpl, D.M.F.Van Aalten, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.95 / 2.31
Space group I 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 129.817, 145.723, 152.331, 90.00, 90.00, 90.00
R / Rfree (%) 18.635 / 23.691

Other elements in 2wb5:

The structure of Glcnacstatins Are Nanomolar Inhibitors of Human O-Glcnacase Inducing Cellular Hyper-O-Glcnacylation also contains other interesting chemical elements:

Chlorine (Cl) 5 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Glcnacstatins Are Nanomolar Inhibitors of Human O-Glcnacase Inducing Cellular Hyper-O-Glcnacylation (pdb code 2wb5). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Glcnacstatins Are Nanomolar Inhibitors of Human O-Glcnacase Inducing Cellular Hyper-O-Glcnacylation, PDB code: 2wb5:

Sodium binding site 1 out of 1 in 2wb5

Go back to Sodium Binding Sites List in 2wb5
Sodium binding site 1 out of 1 in the Glcnacstatins Are Nanomolar Inhibitors of Human O-Glcnacase Inducing Cellular Hyper-O-Glcnacylation


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Glcnacstatins Are Nanomolar Inhibitors of Human O-Glcnacase Inducing Cellular Hyper-O-Glcnacylation within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na1627

b:49.2
occ:1.00
 N A:ASN390 3.4 30.2 1.0
CA A:ARG389 3.8 32.0 1.0
CB A:ARG389 4.0 32.3 1.0
OD1 A:ASN390 4.0 29.5 1.0
C A:ARG389 4.2 31.5 1.0
CB A:ASN390 4.2 29.0 1.0
CG A:ASN390 4.3 30.2 1.0
CA A:ASN390 4.4 29.6 1.0
O A:HOH2128 4.5 29.1 1.0
CG A:ARG389 4.7 33.5 1.0
O A:ASN390 4.8 27.3 1.0
O A:HOH2144 4.9 48.7 1.0

Reference:

H.C.Dorfmueller, V.S.Borodkin, M.Schimpl, D.M.F.Van Aalten. Glcnacstatins Are Nanomolar Inhibitors of Human O- Glcnacase Inducing Cellular Hyper-O-Glcnacylation Biochem.J. V. 420 221 2009.
ISSN: ISSN 0264-6021
PubMed: 19275764
DOI: 10.1042/BJ20090110
Page generated: Sun Aug 17 11:52:31 2025

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