Sodium in PDB 2vt4: Turkey BETA1 Adrenergic Receptor with Stabilising Mutations and Bound Cyanopindolol

The structure of Turkey BETA1 Adrenergic Receptor with Stabilising Mutations and Bound Cyanopindolol, PDB code: 2vt4 was solved by A.Warne, M.J.Serrano-Vega, J.G.Baker, R.Moukhametzianov, P.C.Edwards, R.Henderson, A.G.W.Leslie, C.G.Tate, G.F.X.Schertler, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.10 / 2.70
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	55.500, 86.800, 95.500, 67.60, 73.30, 85.80
R / Rfree (%)	21.2 / 26.8

The binding sites of Sodium atom in the Turkey BETA1 Adrenergic Receptor with Stabilising Mutations and Bound Cyanopindolol (pdb code 2vt4). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 4 binding sites of Sodium where determined in the Turkey BETA1 Adrenergic Receptor with Stabilising Mutations and Bound Cyanopindolol, PDB code: 2vt4:
Jump to Sodium binding site number: 1; 2; 3; 4;

Sodium binding site 1 out of 4 in the Turkey BETA1 Adrenergic Receptor with Stabilising Mutations and Bound Cyanopindolol


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Turkey BETA1 Adrenergic Receptor with Stabilising Mutations and Bound Cyanopindolol within 5.0Å range: probe atom residue distance (Å) B Occ A:Na401 b:34.0 occ:1.00 O A:CYS198 2.3 30.9 1.0 O A:ASP195 2.3 39.7 1.0 O A:HOH2006 2.5 39.3 1.0 O A:CYS192 2.5 36.8 1.0 O A:HOH2002 2.5 50.2 1.0 C A:CYS198 3.5 38.8 1.0 C A:ASP195 3.5 44.8 1.0 C A:CYS192 3.7 32.7 1.0 O A:TYR193 4.0 39.8 1.0 CA A:PRO196 4.1 44.6 1.0 CA A:TYR193 4.2 28.8 1.0 C A:TYR193 4.2 36.3 1.0 CA A:CYS198 4.2 37.9 1.0 N A:PRO196 4.3 42.9 1.0 N A:CYS198 4.3 31.9 1.0 CB A:CYS198 4.4 26.0 1.0 N A:TYR193 4.4 28.9 1.0 C A:PRO196 4.4 41.5 1.0 O A:PRO196 4.5 48.7 1.0 N A:CYS199 4.6 34.5 1.0 CB A:SER111 4.6 35.4 1.0 CA A:ASP195 4.6 46.3 1.0 N A:ASP195 4.6 43.8 1.0 SG A:CYS192 4.6 64.2 1.0 CA A:CYS199 4.8 32.8 1.0 CA A:CYS192 4.8 39.5 1.0 C A:GLN194 4.9 42.1 1.0 SG A:CYS198 5.0 48.8 1.0 SG A:CYS114 5.0 30.0 1.0 N A:GLN194 5.0 33.7 1.0

Sodium binding site 2 out of 4 in the Turkey BETA1 Adrenergic Receptor with Stabilising Mutations and Bound Cyanopindolol


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Turkey BETA1 Adrenergic Receptor with Stabilising Mutations and Bound Cyanopindolol within 5.0Å range: probe atom residue distance (Å) B Occ B:Na401 b:40.6 occ:1.00 O B:ASP195 2.5 37.6 1.0 O B:CYS198 2.5 34.3 1.0 O B:CYS192 2.7 27.9 1.0 O B:HOH2004 2.7 21.5 1.0 C B:ASP195 3.5 32.4 1.0 C B:CYS198 3.6 39.5 1.0 C B:CYS192 3.8 34.0 1.0 O B:TYR193 3.9 31.0 1.0 C B:TYR193 3.9 36.8 1.0 CA B:TYR193 4.0 34.4 1.0 N B:ASP195 4.2 26.7 1.0 CA B:PRO196 4.2 24.8 1.0 N B:PRO196 4.2 22.4 1.0 N B:CYS198 4.3 23.2 1.0 CA B:CYS198 4.3 39.0 1.0 N B:TYR193 4.4 32.5 1.0 CB B:CYS198 4.4 30.6 1.0 CA B:ASP195 4.4 35.6 1.0 C B:PRO196 4.5 27.4 1.0 N B:GLN194 4.5 37.8 1.0 SG B:CYS192 4.6 63.9 1.0 OG B:SER111 4.6 44.3 1.0 O B:PRO196 4.7 30.4 1.0 N B:CYS199 4.7 33.3 1.0 C B:GLN194 4.9 36.3 1.0 CA B:CYS192 4.9 30.7 1.0 SG B:CYS114 5.0 24.0 1.0 CB B:ASP195 5.0 32.1 1.0

Sodium binding site 3 out of 4 in the Turkey BETA1 Adrenergic Receptor with Stabilising Mutations and Bound Cyanopindolol


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of Turkey BETA1 Adrenergic Receptor with Stabilising Mutations and Bound Cyanopindolol within 5.0Å range: probe atom residue distance (Å) B Occ C:Na401 b:36.5 occ:1.00 O C:ASP195 2.4 35.1 1.0 O C:CYS198 2.5 35.5 1.0 O C:HOH2005 2.6 24.4 1.0 O C:CYS192 2.6 32.0 1.0 C C:ASP195 3.5 33.8 1.0 C C:CYS198 3.6 39.1 1.0 C C:CYS192 3.7 35.5 1.0 C C:TYR193 3.9 34.4 1.0 O C:TYR193 3.9 29.4 1.0 CA C:TYR193 4.0 32.7 1.0 N C:ASP195 4.2 25.6 1.0 CA C:PRO196 4.2 24.1 1.0 N C:PRO196 4.2 22.3 1.0 N C:CYS198 4.3 23.1 1.0 CA C:CYS198 4.3 42.1 1.0 N C:TYR193 4.3 31.0 1.0 CB C:CYS198 4.4 31.8 1.0 CA C:ASP195 4.4 41.0 1.0 C C:PRO196 4.5 29.1 1.0 N C:GLN194 4.5 35.6 1.0 SG C:CYS192 4.6 67.0 1.0 OG C:SER111 4.6 46.2 1.0 O C:PRO196 4.7 28.6 1.0 N C:CYS199 4.7 32.7 1.0 CA C:CYS192 4.9 33.0 1.0 C C:GLN194 4.9 36.9 1.0 SG C:CYS114 5.0 26.4 1.0 CB C:ASP195 5.0 34.7 1.0

Sodium binding site 4 out of 4 in the Turkey BETA1 Adrenergic Receptor with Stabilising Mutations and Bound Cyanopindolol


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 4 of Turkey BETA1 Adrenergic Receptor with Stabilising Mutations and Bound Cyanopindolol within 5.0Å range: probe atom residue distance (Å) B Occ D:Na401 b:39.6 occ:1.00 O D:HOH2004 2.3 49.8 1.0 O D:CYS198 2.3 34.1 1.0 O D:ASP195 2.4 40.3 1.0 O D:CYS192 2.5 39.5 1.0 O D:HOH2002 2.7 40.8 1.0 C D:CYS198 3.5 39.0 1.0 C D:ASP195 3.5 44.4 1.0 C D:CYS192 3.7 32.2 1.0 O D:TYR193 4.0 40.6 1.0 CA D:PRO196 4.1 42.8 1.0 CA D:TYR193 4.2 27.0 1.0 C D:TYR193 4.2 32.9 1.0 CA D:CYS198 4.2 38.2 1.0 N D:PRO196 4.3 41.2 1.0 N D:CYS198 4.3 32.6 1.0 CB D:CYS198 4.4 27.5 1.0 N D:TYR193 4.4 24.5 1.0 C D:PRO196 4.4 46.2 1.0 O D:PRO196 4.5 49.5 1.0 N D:CYS199 4.5 31.8 1.0 CA D:ASP195 4.6 43.6 1.0 CB D:SER111 4.6 38.1 1.0 SG D:CYS192 4.6 78.5 1.0 N D:ASP195 4.6 40.0 1.0 CA D:CYS199 4.8 36.5 1.0 CA D:CYS192 4.8 35.2 1.0 SG D:CYS198 4.9 49.3 1.0 C D:GLN194 5.0 41.5 1.0 SG D:CYS114 5.0 37.9 1.0

A.Warne, M.J.Serrano-Vega, J.G.Baker, R.Moukhametzianov, P.C.Edwards, R.Henderson, A.G.W.Leslie, C.G.Tate, G.F.X.Schertler. Structure of A BETA1-Adrenergic G-Protein-Coupled Receptor. Nature V. 454 486 2008.
ISSN: ISSN 0028-0836
PubMed: 18594507
DOI: 10.1038/NATURE07101