Sodium in PDB 2p99: E. Coli Methionine Aminopeptidase Monometalated with Inhibitor YE6

Enzymatic activity of E. Coli Methionine Aminopeptidase Monometalated with Inhibitor YE6

All present enzymatic activity of E. Coli Methionine Aminopeptidase Monometalated with Inhibitor YE6:
3.4.11.18;

Protein crystallography data

The structure of E. Coli Methionine Aminopeptidase Monometalated with Inhibitor YE6, PDB code: 2p99 was solved by Q.Ye, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	20.00 / 1.80
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	38.310, 61.700, 50.640, 90.00, 105.43, 90.00
*R / R_free (%)*	22.7 / 26.3

Other elements in 2p99:

The structure of E. Coli Methionine Aminopeptidase Monometalated with Inhibitor YE6 also contains other interesting chemical elements:

Manganese	(Mn)	1 atom
Chlorine	(Cl)	1 atom

Sodium Binding Sites:

The binding sites of Sodium atom in the E. Coli Methionine Aminopeptidase Monometalated with Inhibitor YE6 (pdb code 2p99). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the E. Coli Methionine Aminopeptidase Monometalated with Inhibitor YE6, PDB code: 2p99:

Sodium binding site 1 out of 1 in 2p99

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Sodium Binding Sites List in 2p99

Sodium binding site 1 out of 1 in the E. Coli Methionine Aminopeptidase Monometalated with Inhibitor YE6

Mono view

Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of E. Coli Methionine Aminopeptidase Monometalated with Inhibitor YE6 within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Na264 b:24.6 occ:1.00	O	A:VAL76	2.5	24.3	1.0
	O	A:ASN74	2.6	21.9	1.0
	O	A:SER231	2.6	16.1	1.0
	O	A:HOH277	2.6	25.5	1.0
	C	A:ASN74	3.3	23.6	1.0
	C	A:SER231	3.5	14.4	1.0
	O	A:HOH388	3.6	18.1	1.0
	C	A:VAL76	3.6	23.8	1.0
	N	A:ASN74	3.6	22.1	1.0
	CA	A:ASN74	3.8	22.2	1.0
	C	A:ILE73	3.8	21.4	1.0
	N	A:VAL76	4.0	23.8	1.0
	N	A:SER231	4.0	16.8	1.0
	CB	A:SER231	4.0	15.1	1.0
	CA	A:SER231	4.1	15.3	1.0
	O	A:ILE73	4.1	22.3	1.0
	O	A:SER72	4.2	17.9	1.0
	N	A:GLU75	4.3	24.3	1.0
	CA	A:VAL76	4.3	23.5	1.0
	C	A:GLU75	4.4	25.1	1.0
	C	A:SER72	4.4	19.0	1.0
	CA	A:ILE73	4.5	21.2	1.0
	N	A:ILE73	4.5	19.3	1.0
	N	A:ALA232	4.5	14.3	1.0
	N	A:VAL77	4.6	23.8	1.0
	CB	A:SER72	4.6	17.2	1.0
	O	A:HOH279	4.7	17.3	1.0
	CA	A:VAL77	4.7	22.8	1.0
	CA	A:GLU75	4.7	25.5	1.0
	CE	A:MET112	4.7	11.9	1.0
	CB	A:VAL76	4.8	23.7	1.0
	CD1	A:ILE93	4.8	18.8	1.0
	CG1	A:ILE93	4.8	16.8	1.0
	OG	A:SER231	4.8	15.4	1.0
	CA	A:ALA232	4.8	13.5	1.0
	O	A:ILE93	4.8	16.3	1.0

Reference:

M.Huang, S.X.Xie, Z.Q.Ma, Q.Q.Huang, F.J.Nan, Q.Z.Ye. Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis. J.Med.Chem. V. 50 5735 2007.
ISSN: ISSN 0022-2623
PubMed: 17948983
DOI: 10.1021/JM700930K

Page generated: Mon Oct 7 03:40:07 2024

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