Sodium in PDB 2o11: Mycobacterium Tuberculosis Chorismate Synthase

All present enzymatic activity of Mycobacterium Tuberculosis Chorismate Synthase:
4.2.3.5;

The structure of Mycobacterium Tuberculosis Chorismate Synthase, PDB code: 2o11 was solved by M.Bruning, H.D.Bartunik, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.71 / 1.65
Space group	P 64 2 2
Cell size a, b, c (Å), α, β, γ (°)	133.586, 133.586, 160.043, 90.00, 90.00, 120.00
R / Rfree (%)	18.9 / 20.8

The binding sites of Sodium atom in the Mycobacterium Tuberculosis Chorismate Synthase (pdb code 2o11). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 3 binding sites of Sodium where determined in the Mycobacterium Tuberculosis Chorismate Synthase, PDB code: 2o11:
Jump to Sodium binding site number: 1; 2; 3;

Sodium binding site 1 out of 3 in the Mycobacterium Tuberculosis Chorismate Synthase


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Mycobacterium Tuberculosis Chorismate Synthase within 5.0Å range: probe atom residue distance (Å) B Occ A:Na601 b:26.0 occ:1.00 O A:HOH1078 2.7 28.2 0.5 O A:HOH985 2.9 33.4 1.0 N A:ALA376 3.2 21.0 1.0 O A:HOH992 3.3 27.3 0.5 N A:LEU375 3.6 17.9 1.0 O A:HOH990 3.7 48.8 1.0 CB A:ALA376 3.7 24.0 1.0 CB A:LEU375 3.9 22.4 1.0 CB A:SER374 3.9 20.4 1.0 CA A:GLY25 4.0 20.1 1.0 CA A:LEU375 4.1 18.6 1.0 CA A:ALA376 4.1 21.3 1.0 O A:ALA24 4.1 19.4 1.0 C A:LEU375 4.1 17.9 1.0 OG A:SER374 4.2 22.9 1.0 C A:SER374 4.3 19.4 1.0 CA A:SER374 4.6 19.8 1.0 O A:HOH991 4.6 27.6 0.5 O A:GLY25 4.7 21.9 1.0 C A:ALA24 4.7 19.6 1.0 C A:GLY25 4.8 20.8 1.0 N A:GLY25 4.8 21.4 1.0 O A:HOH1115 4.8 34.4 0.5 O A:HOH986 4.9 35.4 1.0 CG A:LEU375 5.0 20.7 1.0

Sodium binding site 2 out of 3 in the Mycobacterium Tuberculosis Chorismate Synthase


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Mycobacterium Tuberculosis Chorismate Synthase within 5.0Å range: probe atom residue distance (Å) B Occ A:Na602 b:28.1 occ:1.00 O A:HOH1042 2.8 35.2 1.0 ND2 A:ASN293 3.0 21.8 1.0 O A:HOH1041 3.1 61.7 1.0 CG A:PRO180 3.5 44.3 1.0 NE A:ARG309 3.6 26.5 1.0 CB A:ASN293 3.7 22.6 1.0 CD A:ARG309 3.7 20.1 0.5 CG A:ASN293 3.8 21.6 1.0 CG A:PRO307 3.9 24.2 1.0 CB A:PRO307 3.9 26.7 1.0 CD A:PRO180 4.0 40.5 1.0 CD A:PRO307 4.3 26.5 1.0 CG A:ARG309 4.4 23.6 1.0 O A:HOH1045 4.4 53.4 1.0 CZ A:ARG309 4.7 25.3 1.0 CB A:PRO180 4.8 39.9 1.0 O A:ASN293 4.8 23.3 1.0 O A:PRO307 4.9 21.8 1.0 CA A:ASN293 5.0 22.6 1.0

Sodium binding site 3 out of 3 in the Mycobacterium Tuberculosis Chorismate Synthase


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of Mycobacterium Tuberculosis Chorismate Synthase within 5.0Å range: probe atom residue distance (Å) B Occ A:Na603 b:27.3 occ:1.00 OE2 A:GLU9 2.8 14.2 0.5 N A:GLY8 2.9 19.2 1.0 O A:GLY8 3.6 18.8 1.0 CD A:ARG135 3.7 20.5 1.0 CA A:GLY8 3.7 20.1 1.0 C A:GLY8 3.7 26.4 1.0 CD A:GLU9 3.7 17.2 0.5 C A:ALA7 3.9 17.6 1.0 CA A:ALA7 3.9 14.3 1.0 NH1 A:ARG135 3.9 18.9 1.0 OE1 A:GLU9 4.0 12.3 0.5 NE A:ARG135 4.0 18.4 1.0 CZ A:ARG135 4.2 16.5 1.0 CB A:ALA7 4.2 18.2 1.0 N A:GLU9 4.5 20.6 1.0 CG A:ARG135 4.7 19.5 1.0 CG A:GLU9 5.0 24.4 1.0

M.Bruning, G.P.Bourenkov, N.I.Strizhov, H.D.Bartunik. Complexes of Chorismate Synthase From M. Tuberculosis To Be Published.