Sodium in PDB 2iaj: Crystal Structure of K103N/Y181C Mutant Hiv-1 Reverse Transcriptase (Rt) in Complex with Atp

Enzymatic activity of Crystal Structure of K103N/Y181C Mutant Hiv-1 Reverse Transcriptase (Rt) in Complex with Atp

All present enzymatic activity of Crystal Structure of K103N/Y181C Mutant Hiv-1 Reverse Transcriptase (Rt) in Complex with Atp:
2.7.7.49;

Protein crystallography data

The structure of Crystal Structure of K103N/Y181C Mutant Hiv-1 Reverse Transcriptase (Rt) in Complex with Atp, PDB code: 2iaj was solved by K.Das, E.Arnold, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	19.96 / 2.50
*Space group*	C 1 2 1
*Cell size a, b, c (Å), α, β, γ (°)*	237.400, 71.130, 94.210, 90.00, 105.86, 90.00
*R / R_free (%)*	23.3 / 28.4

Other elements in 2iaj:

The structure of Crystal Structure of K103N/Y181C Mutant Hiv-1 Reverse Transcriptase (Rt) in Complex with Atp also contains other interesting chemical elements:

Manganese

(Mn)

3 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure of K103N/Y181C Mutant Hiv-1 Reverse Transcriptase (Rt) in Complex with Atp (pdb code 2iaj). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of K103N/Y181C Mutant Hiv-1 Reverse Transcriptase (Rt) in Complex with Atp, PDB code: 2iaj:

Sodium binding site 1 out of 1 in 2iaj

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Sodium Binding Sites List in 2iaj

Sodium binding site 1 out of 1 in the Crystal Structure of K103N/Y181C Mutant Hiv-1 Reverse Transcriptase (Rt) in Complex with Atp

Mono view

Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of K103N/Y181C Mutant Hiv-1 Reverse Transcriptase (Rt) in Complex with Atp within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Na564 b:63.1 occ:1.00	O	A:LYS101	2.6	71.5	1.0
	OD1	A:ASN103	2.6	75.8	1.0
	N	A:ASN103	2.7	71.6	1.0
	O	A:HOH667	2.7	72.7	1.0
	OH	A:TYR188	2.7	61.6	1.0
	O	A:HOH663	2.7	83.5	1.0
	C	A:LYS102	3.3	69.6	1.0
	CA	A:LYS102	3.3	69.8	1.0
	CG	A:ASN103	3.4	77.0	1.0
	CB	A:ASN103	3.4	76.4	1.0
	CA	A:ASN103	3.6	75.9	1.0
	C	A:LYS101	3.6	69.3	1.0
	N	A:LYS102	4.0	69.2	1.0
	CZ	A:TYR188	4.0	57.4	1.0
	O	A:ASN103	4.3	80.1	1.0
	O	A:LYS102	4.3	69.2	1.0
	CG2	A:VAL106	4.4	68.2	1.0
	C	A:ASN103	4.5	78.1	1.0
	CB	A:LYS102	4.6	70.6	1.0
	ND2	A:ASN103	4.7	70.4	1.0
	CE2	A:TYR188	4.8	56.0	1.0
	CD2	A:TYR318	4.9	59.6	1.0
	CE2	A:TYR318	4.9	62.5	1.0
	CE1	A:TYR188	4.9	57.3	1.0
	N	A:LYS101	4.9	60.8	1.0
	CA	A:LYS101	5.0	67.7	1.0
	CB	A:LEU100	5.0	49.5	1.0

Reference:

K.Das, S.G.Sarafianos, A.D.Clark, P.L.Boyer, S.H.Hughes, E.Arnold. Crystal Structures of Clinically Relevant LYS103ASN/TYR181CYS Double Mutant Hiv-1 Reverse Transcriptase in Complexes with Atp and Non-Nucleoside Inhibitor Hby 097. J.Mol.Biol. V. 365 77 2007.
ISSN: ISSN 0022-2836
PubMed: 17056061
DOI: 10.1016/J.JMB.2006.08.097

Page generated: Tue Dec 15 05:51:00 2020

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