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Sodium in PDB 2clf: Tryptophan Synthase in Complex with N-(4'- Trifluoromethoxybenzoyl)-2-Amino-1-Ethylphosphate (F6) - HIGHF6 Complex

Enzymatic activity of Tryptophan Synthase in Complex with N-(4'- Trifluoromethoxybenzoyl)-2-Amino-1-Ethylphosphate (F6) - HIGHF6 Complex

All present enzymatic activity of Tryptophan Synthase in Complex with N-(4'- Trifluoromethoxybenzoyl)-2-Amino-1-Ethylphosphate (F6) - HIGHF6 Complex:
4.2.1.20;

Protein crystallography data

The structure of Tryptophan Synthase in Complex with N-(4'- Trifluoromethoxybenzoyl)-2-Amino-1-Ethylphosphate (F6) - HIGHF6 Complex, PDB code: 2clf was solved by H.Ngo, R.Harris, N.Kimmich, P.Casino, D.Niks, L.Blumenstein, T.R.Barends, V.Kulik, M.Weyand, I.Schlichting, M.F.Dunn, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.15 / 1.7
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 182.840, 58.989, 67.423, 90.00, 94.78, 90.00
R / Rfree (%) 17.6 / 19.6

Other elements in 2clf:

The structure of Tryptophan Synthase in Complex with N-(4'- Trifluoromethoxybenzoyl)-2-Amino-1-Ethylphosphate (F6) - HIGHF6 Complex also contains other interesting chemical elements:

Fluorine (F) 6 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Tryptophan Synthase in Complex with N-(4'- Trifluoromethoxybenzoyl)-2-Amino-1-Ethylphosphate (F6) - HIGHF6 Complex (pdb code 2clf). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Tryptophan Synthase in Complex with N-(4'- Trifluoromethoxybenzoyl)-2-Amino-1-Ethylphosphate (F6) - HIGHF6 Complex, PDB code: 2clf:

Sodium binding site 1 out of 1 in 2clf

Go back to Sodium Binding Sites List in 2clf
Sodium binding site 1 out of 1 in the Tryptophan Synthase in Complex with N-(4'- Trifluoromethoxybenzoyl)-2-Amino-1-Ethylphosphate (F6) - HIGHF6 Complex


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Tryptophan Synthase in Complex with N-(4'- Trifluoromethoxybenzoyl)-2-Amino-1-Ethylphosphate (F6) - HIGHF6 Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Na1398

b:15.0
occ:1.00
 O B:GLY232 2.2 14.2 1.0
O B:SER308 2.3 12.9 1.0
O B:HOH2286 2.4 26.7 1.0
O B:HOH2272 2.4 16.4 1.0
O B:PHE306 2.4 28.9 1.0
C B:GLY232 3.4 13.2 1.0
C B:SER308 3.5 14.3 1.0
C B:PHE306 3.5 28.8 1.0
CB B:PHE306 3.8 31.4 1.0
CG B:PRO270 3.8 11.7 1.0
CD B:PRO270 3.9 13.2 1.0
N B:SER308 4.0 17.2 1.0
CA B:GLY232 4.0 13.1 1.0
CA B:PHE306 4.1 30.3 1.0
CD2 B:PHE306 4.1 30.4 1.0
O B:GLY268 4.2 14.6 1.0
N B:PHE306 4.3 32.4 1.0
O B:VAL231 4.3 13.6 1.0
CA B:SER308 4.3 15.0 1.0
CG B:PHE306 4.4 31.4 1.0
N B:VAL309 4.4 13.3 1.0
N B:GLY233 4.5 11.9 1.0
CA B:VAL309 4.5 12.7 1.0
O B:LEU304 4.6 19.1 1.0
N B:PRO307 4.6 27.0 1.0
CB B:VAL309 4.6 13.1 1.0
C B:PRO307 4.6 21.3 1.0
OG B:SER297 4.7 31.9 1.0
OE2 B:GLU256 4.8 13.3 1.0
CA B:GLY233 4.8 11.7 1.0
N B:GLY232 4.8 12.7 1.0
CA B:PRO307 4.9 24.5 1.0
C B:VAL231 4.9 12.4 1.0

Reference:

H.Ngo, R.Harris, N.Kimmich, P.Casino, D.Niks, L.Blumenstein, T.R.Barends, V.Kulik, M.Weyand, I.Schlichting, M.F.Dunn. Synthesis and Characterization of Allosteric Probes of Substrate Channeling in the Tryptophan Synthase Bienzyme Complex. Biochemistry V. 46 7713 2007.
ISSN: ISSN 0006-2960
PubMed: 17559195
DOI: 10.1021/BI700385F
Page generated: Mon Oct 7 02:09:19 2024

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