Sodium in PDB 2bb7: Mn Form of E. Coli Methionine Aminopeptidase in Complex with A Quinolinyl Sulfonamide Inhibitor

Enzymatic activity of Mn Form of E. Coli Methionine Aminopeptidase in Complex with A Quinolinyl Sulfonamide Inhibitor

All present enzymatic activity of Mn Form of E. Coli Methionine Aminopeptidase in Complex with A Quinolinyl Sulfonamide Inhibitor:
3.4.11.18;

Protein crystallography data

The structure of Mn Form of E. Coli Methionine Aminopeptidase in Complex with A Quinolinyl Sulfonamide Inhibitor, PDB code: 2bb7 was solved by Q.Z.Ye, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	17.62 / 1.70
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	38.039, 60.416, 50.521, 90.00, 104.40, 90.00
*R / R_free (%)*	18.7 / 23.3

Other elements in 2bb7:

The structure of Mn Form of E. Coli Methionine Aminopeptidase in Complex with A Quinolinyl Sulfonamide Inhibitor also contains other interesting chemical elements:

Manganese

(Mn)

3 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Mn Form of E. Coli Methionine Aminopeptidase in Complex with A Quinolinyl Sulfonamide Inhibitor (pdb code 2bb7). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Mn Form of E. Coli Methionine Aminopeptidase in Complex with A Quinolinyl Sulfonamide Inhibitor, PDB code: 2bb7:

Sodium binding site 1 out of 1 in 2bb7

Go back to

Sodium Binding Sites List in 2bb7

Sodium binding site 1 out of 1 in the Mn Form of E. Coli Methionine Aminopeptidase in Complex with A Quinolinyl Sulfonamide Inhibitor

Mono view

Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Mn Form of E. Coli Methionine Aminopeptidase in Complex with A Quinolinyl Sulfonamide Inhibitor within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Na304 b:22.2 occ:1.00	O	A:HOH364	2.2	18.6	1.0
	O	A:ASN74	2.2	18.1	1.0
	O	A:SER231	2.3	16.3	1.0
	O	A:VAL76	2.4	18.4	1.0
	C	A:ASN74	3.2	17.4	1.0
	C	A:SER231	3.3	16.6	1.0
	C	A:VAL76	3.5	17.4	1.0
	O	A:HOH310	3.6	16.8	1.0
	N	A:ASN74	3.7	16.3	1.0
	N	A:SER231	3.8	18.5	1.0
	CA	A:SER231	3.9	17.0	1.0
	CA	A:ASN74	3.9	17.1	1.0
	CB	A:SER231	3.9	18.2	1.0
	C	A:ILE73	4.0	16.2	1.0
	N	A:VAL76	4.0	17.2	1.0
	O	A:ILE73	4.2	16.3	1.0
	N	A:GLU75	4.3	18.6	1.0
	O	A:HOH395	4.3	16.5	1.0
	CA	A:VAL76	4.3	18.3	1.0
	C	A:GLU75	4.3	18.6	1.0
	N	A:ALA232	4.4	15.8	1.0
	O	A:SER72	4.4	14.8	1.0
	N	A:VAL77	4.4	18.1	1.0
	CA	A:VAL77	4.5	18.3	1.0
	OG	A:SER231	4.6	15.6	1.0
	C	A:SER72	4.6	15.8	1.0
	CA	A:GLU75	4.6	18.4	1.0
	N	A:ILE73	4.7	15.9	1.0
	CA	A:ILE73	4.7	16.3	1.0
	CA	A:ALA232	4.7	16.0	1.0
	CB	A:SER72	4.8	16.0	1.0
	CD1	A:ILE93	4.9	20.0	1.0
	CG1	A:ILE93	4.9	18.3	1.0
	CB	A:VAL76	4.9	18.1	1.0
	CE	A:MET112	4.9	18.4	1.0
	O	A:GLU75	4.9	17.8	1.0
	O	A:VAL77	5.0	17.6	1.0
	C	A:VAL77	5.0	17.6	1.0

Reference:

M.Huang, S.X.Xie, Z.Q.Ma, R.P.Hanzlik, Q.Z.Ye. Metal Mediated Inhibition of Methionine Aminopeptidase By Quinolinyl Sulfonamides Biochem.Biophys.Res.Commun. V. 339 506 2006.
ISSN: ISSN 0006-291X
PubMed: 16300729
DOI: 10.1016/J.BBRC.2005.11.042

Page generated: Tue Dec 15 05:45:44 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3

	© Copyright 2008-2020 by atomistry.com
Home \| Site Map \| Copyright \| Contact us \| Privacy