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Sodium in PDB 2aoh: Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with A Substrate Analog P6-Pr

Enzymatic activity of Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with A Substrate Analog P6-Pr

All present enzymatic activity of Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with A Substrate Analog P6-Pr:
3.4.23.16;

Protein crystallography data

The structure of Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with A Substrate Analog P6-Pr, PDB code: 2aoh was solved by Y.Tie, P.I.Boross, Y.F.Wang, L.Gaddis, F.Liu, X.Chen, J.Tozser, R.W.Harrison, I.T.Weber, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 1.42
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 58.882, 86.283, 46.404, 90.00, 90.00, 90.00
R / Rfree (%) 17.9 / 23.3

Other elements in 2aoh:

The structure of Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with A Substrate Analog P6-Pr also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with A Substrate Analog P6-Pr (pdb code 2aoh). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with A Substrate Analog P6-Pr, PDB code: 2aoh:

Sodium binding site 1 out of 1 in 2aoh

Go back to Sodium Binding Sites List in 2aoh
Sodium binding site 1 out of 1 in the Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with A Substrate Analog P6-Pr


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with A Substrate Analog P6-Pr within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na500

b:30.0
occ:1.00
 O A:HOH1024 2.3 25.2 1.0
O A:ASP60 2.4 20.1 1.0
O A:HOH1108 2.4 28.4 1.0
O A:HOH1035 2.5 29.3 1.0
O A:HOH1154 2.5 24.4 0.5
O A:HOH1066 2.8 30.4 1.0
C A:ASP60 3.3 19.2 1.0
N A:ASP60 3.7 16.5 1.0
CA A:ASP60 3.9 17.6 1.0
O A:HOH1232 4.1 27.2 0.5
O A:ARG41 4.2 24.6 1.0
CB A:ASP60 4.3 19.3 1.0
N A:GLN61 4.4 19.4 1.0
N A:ARG41 4.5 29.0 1.0
O A:GLN61 4.6 24.7 1.0
CB A:GLN61 4.6 27.2 1.0
O A:PRO39 4.7 27.9 1.0
C A:TYR59 4.7 14.5 1.0
CD1 A:ILE62 4.7 18.5 1.0
C A:GLN61 4.8 19.4 1.0
CA A:GLY40 4.8 27.1 1.0
CA A:GLN61 4.8 20.6 1.0

Reference:

Y.Tie, P.I.Boross, Y.F.Wang, L.Gaddis, F.Liu, X.Chen, J.Tozser, R.W.Harrison, I.T.Weber. Molecular Basis For Substrate Recognition and Drug Resistance From 1.1 to 1.6 Angstroms Resolution Crystal Structures of Hiv-1 Protease Mutants with Substrate Analogs. Febs J. V. 272 5265 2005.
ISSN: ISSN 1742-464X
PubMed: 16218957
DOI: 10.1111/J.1742-4658.2005.04923.X
Page generated: Mon Oct 7 01:54:37 2024

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