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Sodium in PDB 2aoe: Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with A Substrate Analog Ca-P2

Enzymatic activity of Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with A Substrate Analog Ca-P2

All present enzymatic activity of Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with A Substrate Analog Ca-P2:
3.4.23.16;

Protein crystallography data

The structure of Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with A Substrate Analog Ca-P2, PDB code: 2aoe was solved by Y.Tie, P.I.Boross, Y.F.Wang, L.Gaddis, F.Liu, X.Chen, J.Tozser, R.W.Harrison, I.T.Weber, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 1.54
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 57.892, 85.962, 46.190, 90.00, 90.00, 90.00
R / Rfree (%) 13 / 19.8

Other elements in 2aoe:

The structure of Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with A Substrate Analog Ca-P2 also contains other interesting chemical elements:

Chlorine (Cl) 3 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with A Substrate Analog Ca-P2 (pdb code 2aoe). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with A Substrate Analog Ca-P2, PDB code: 2aoe:

Sodium binding site 1 out of 1 in 2aoe

Go back to Sodium Binding Sites List in 2aoe
Sodium binding site 1 out of 1 in the Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with A Substrate Analog Ca-P2


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with A Substrate Analog Ca-P2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na501

b:27.9
occ:1.00
 O A:HOH1059 2.2 24.6 1.0
O A:HOH1076 2.3 31.7 1.0
O A:ASP60 2.3 17.9 1.0
O A:HOH1136 2.5 43.8 1.0
O A:HOH1045 2.5 29.9 1.0
O A:HOH1047 2.9 36.5 1.0
C A:ASP60 3.4 16.6 1.0
N A:ASP60 3.7 16.1 1.0
CA A:ASP60 4.0 17.0 1.0
O A:ARG41 4.3 21.9 1.0
CB A:ASP60 4.4 19.6 1.0
O A:HOH1172 4.4 52.0 0.5
N A:GLN61 4.4 16.4 1.0
O A:PRO39 4.5 19.8 1.0
CB A:GLN61 4.5 23.7 1.0
O A:GLN61 4.6 20.7 1.0
C A:TYR59 4.7 13.2 1.0
CD1 A:ILE62 4.7 17.5 1.0
N A:ARG41 4.7 24.7 1.0
CA A:GLY40 4.7 26.2 1.0
C A:GLN61 4.8 18.4 1.0
CA A:GLN61 4.8 17.5 1.0

Reference:

Y.Tie, P.I.Boross, Y.F.Wang, L.Gaddis, F.Liu, X.Chen, J.Tozser, R.W.Harrison, I.T.Weber. Molecular Basis For Substrate Recognition and Drug Resistance From 1.1 to 1.6 Angstroms Resolution Crystal Structures of Hiv-1 Protease Mutants with Substrate Analogs. Febs J. V. 272 5265 2005.
ISSN: ISSN 1742-464X
PubMed: 16218957
DOI: 10.1111/J.1742-4658.2005.04923.X
Page generated: Mon Oct 7 01:54:37 2024

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