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Sodium in PDB 2aoc: Crystal Structure Analysis of Hiv-1 Protease Mutant I84V with A Substrate Analog P2-Nc

Enzymatic activity of Crystal Structure Analysis of Hiv-1 Protease Mutant I84V with A Substrate Analog P2-Nc

All present enzymatic activity of Crystal Structure Analysis of Hiv-1 Protease Mutant I84V with A Substrate Analog P2-Nc:
3.4.23.16;

Protein crystallography data

The structure of Crystal Structure Analysis of Hiv-1 Protease Mutant I84V with A Substrate Analog P2-Nc, PDB code: 2aoc was solved by Y.Tie, P.I.Boross, Y.F.Wang, L.Gaddis, F.Liu, X.Chen, J.Tozser, R.W.Harrison, I.T.Weber, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 1.30
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 57.802, 85.589, 46.461, 90.00, 90.00, 90.00
R / Rfree (%) 12.3 / 16.6

Other elements in 2aoc:

The structure of Crystal Structure Analysis of Hiv-1 Protease Mutant I84V with A Substrate Analog P2-Nc also contains other interesting chemical elements:

Chlorine (Cl) 3 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure Analysis of Hiv-1 Protease Mutant I84V with A Substrate Analog P2-Nc (pdb code 2aoc). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure Analysis of Hiv-1 Protease Mutant I84V with A Substrate Analog P2-Nc, PDB code: 2aoc:

Sodium binding site 1 out of 1 in 2aoc

Go back to Sodium Binding Sites List in 2aoc
Sodium binding site 1 out of 1 in the Crystal Structure Analysis of Hiv-1 Protease Mutant I84V with A Substrate Analog P2-Nc


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure Analysis of Hiv-1 Protease Mutant I84V with A Substrate Analog P2-Nc within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na500

b:21.0
occ:0.50
 O A:HOH1111 2.0 31.1 1.0
O A:HOH1211 2.2 38.9 1.0
O A:HOH1063 2.2 21.2 1.0
O A:ASP60 2.5 12.8 1.0
O A:HOH1172 3.0 38.2 1.0
C A:ASP60 3.4 11.7 1.0
N A:ASP60 3.7 10.7 1.0
CA A:ASP60 3.9 11.6 1.0
CB A:ASP60 4.2 14.5 1.0
O A:ARG41 4.3 18.4 1.0
O A:PRO39 4.3 18.0 1.0
N A:GLN61 4.4 11.9 1.0
CB A:GLN61 4.4 17.8 1.0
CA A:GLY40 4.5 18.0 1.0
N A:ARG41 4.6 17.8 1.0
C A:TYR59 4.7 9.3 1.0
CA A:GLN61 4.8 13.1 1.0
CD1 A:ILE62 4.8 12.9 1.0
C A:GLN61 4.9 12.4 1.0
O A:GLN61 4.9 17.0 1.0
C A:GLY40 4.9 17.0 1.0

Reference:

Y.Tie, P.I.Boross, Y.F.Wang, L.Gaddis, F.Liu, X.Chen, J.Tozser, R.W.Harrison, I.T.Weber. Molecular Basis For Substrate Recognition and Drug Resistance From 1.1 to 1.6 Angstroms Resolution Crystal Structures of Hiv-1 Protease Mutants with Substrate Analogs. Febs J. V. 272 5265 2005.
ISSN: ISSN 1742-464X
PubMed: 16218957
DOI: 10.1111/J.1742-4658.2005.04923.X
Page generated: Mon Oct 7 01:53:21 2024

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