Sodium in PDB 1zum: Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form
Enzymatic activity of Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form
All present enzymatic activity of Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form:
1.2.1.3;
Protein crystallography data
The structure of Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form, PDB code: 1zum
was solved by
H.N.Larson,
H.Weiner,
T.D.Hurley,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
42.63 /
2.10
|
Space group
|
P 1
|
Cell size a, b, c (Å), α, β, γ (°)
|
95.873,
105.261,
162.672,
78.81,
81.95,
88.04
|
R / Rfree (%)
|
20.4 /
23.8
|
Sodium Binding Sites:
Pages:
>>> Page 1 <<<
Page 2, Binding sites: 11 -
12;
Binding sites:
The binding sites of Sodium atom in the Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form
(pdb code 1zum). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total 12 binding sites of Sodium where determined in the
Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form, PDB code: 1zum:
Jump to Sodium binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
9;
10;
Sodium binding site 1 out
of 12 in 1zum
Go back to
Sodium Binding Sites List in 1zum
Sodium binding site 1 out
of 12 in the Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form
Mono view
Stereo pair view
|
A full contact list of Sodium with other atoms in the Na binding
site number 1 of Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Na3701
b:57.0
occ:1.00
|
O
|
A:GLN196
|
2.3
|
47.4
|
1.0
|
O
|
A:VAL40
|
2.5
|
51.5
|
1.0
|
OD1
|
A:ASP109
|
2.6
|
55.5
|
1.0
|
O
|
A:ASP109
|
2.7
|
48.8
|
1.0
|
O
|
A:HOH3851
|
2.7
|
48.7
|
1.0
|
OG1
|
A:THR39
|
2.8
|
44.4
|
1.0
|
CG
|
A:ASP109
|
3.4
|
56.0
|
1.0
|
C
|
A:GLN196
|
3.4
|
47.2
|
1.0
|
C
|
A:VAL40
|
3.6
|
50.2
|
1.0
|
N
|
A:VAL40
|
3.6
|
46.8
|
1.0
|
C
|
A:ASP109
|
3.7
|
49.5
|
1.0
|
CA
|
A:ASP109
|
3.9
|
51.0
|
1.0
|
OD2
|
A:ASP109
|
4.1
|
55.0
|
1.0
|
CA
|
A:VAL40
|
4.1
|
48.1
|
1.0
|
CA
|
A:GLN196
|
4.1
|
43.6
|
1.0
|
CB
|
A:THR39
|
4.1
|
43.5
|
1.0
|
CB
|
A:ASP109
|
4.2
|
53.2
|
1.0
|
C
|
A:THR39
|
4.2
|
45.5
|
1.0
|
CD
|
A:PRO42
|
4.4
|
56.9
|
1.0
|
N
|
A:THR197
|
4.4
|
48.4
|
1.0
|
CA
|
A:THR39
|
4.5
|
46.4
|
1.0
|
CD1
|
A:ILE48
|
4.7
|
54.4
|
1.0
|
CA
|
A:THR197
|
4.7
|
47.8
|
1.0
|
N
|
A:ASN41
|
4.7
|
50.0
|
1.0
|
CB
|
A:GLN196
|
4.7
|
46.3
|
1.0
|
CG2
|
A:THR197
|
4.9
|
44.6
|
1.0
|
CB
|
A:VAL40
|
4.9
|
48.1
|
1.0
|
N
|
A:ASN110
|
4.9
|
46.7
|
1.0
|
CG2
|
A:THR39
|
4.9
|
42.8
|
1.0
|
|
Sodium binding site 2 out
of 12 in 1zum
Go back to
Sodium Binding Sites List in 1zum
Sodium binding site 2 out
of 12 in the Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form
Mono view
Stereo pair view
|
A full contact list of Sodium with other atoms in the Na binding
site number 2 of Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Na3702
b:30.4
occ:1.00
|
O
|
B:GLN196
|
2.3
|
19.0
|
1.0
|
O
|
B:VAL40
|
2.4
|
22.1
|
1.0
|
O
|
B:HOH3783
|
2.5
|
30.5
|
1.0
|
OD1
|
B:ASP109
|
2.5
|
21.8
|
1.0
|
O
|
B:ASP109
|
2.6
|
18.4
|
1.0
|
OG1
|
B:THR39
|
3.2
|
30.1
|
1.0
|
C
|
B:GLN196
|
3.4
|
21.8
|
1.0
|
CG
|
B:ASP109
|
3.4
|
25.4
|
1.0
|
C
|
B:VAL40
|
3.5
|
26.2
|
1.0
|
C
|
B:ASP109
|
3.6
|
19.5
|
1.0
|
N
|
B:VAL40
|
3.7
|
25.7
|
1.0
|
CA
|
B:ASP109
|
3.9
|
18.1
|
1.0
|
O
|
B:HOH3821
|
4.0
|
41.7
|
1.0
|
CA
|
B:GLN196
|
4.1
|
22.8
|
1.0
|
CA
|
B:VAL40
|
4.1
|
26.0
|
1.0
|
CD
|
B:PRO42
|
4.2
|
19.6
|
1.0
|
OD2
|
B:ASP109
|
4.2
|
24.3
|
1.0
|
CB
|
B:ASP109
|
4.2
|
21.5
|
1.0
|
C
|
B:THR39
|
4.4
|
26.5
|
1.0
|
CB
|
B:THR39
|
4.5
|
28.2
|
1.0
|
N
|
B:THR197
|
4.5
|
21.0
|
1.0
|
CB
|
B:GLN196
|
4.6
|
25.9
|
1.0
|
N
|
B:ASN41
|
4.6
|
24.6
|
1.0
|
CA
|
B:THR39
|
4.7
|
27.1
|
1.0
|
CG2
|
B:THR197
|
4.8
|
17.7
|
1.0
|
CD1
|
B:ILE48
|
4.8
|
26.1
|
1.0
|
CA
|
B:THR197
|
4.8
|
19.8
|
1.0
|
N
|
B:ASN110
|
4.8
|
19.7
|
1.0
|
CB
|
B:VAL40
|
4.8
|
30.2
|
1.0
|
CA
|
B:ASN41
|
5.0
|
24.7
|
1.0
|
O
|
B:VAL345
|
5.0
|
20.6
|
1.0
|
|
Sodium binding site 3 out
of 12 in 1zum
Go back to
Sodium Binding Sites List in 1zum
Sodium binding site 3 out
of 12 in the Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form
Mono view
Stereo pair view
|
A full contact list of Sodium with other atoms in the Na binding
site number 3 of Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Na3703
b:34.8
occ:1.00
|
O
|
C:GLN196
|
2.3
|
19.9
|
1.0
|
O
|
C:VAL40
|
2.4
|
28.2
|
1.0
|
O
|
C:HOH3903
|
2.5
|
29.6
|
1.0
|
OD1
|
C:ASP109
|
2.6
|
29.1
|
1.0
|
O
|
C:ASP109
|
2.7
|
24.3
|
1.0
|
O
|
C:HOH3902
|
2.9
|
24.5
|
1.0
|
OG1
|
C:THR39
|
3.1
|
29.9
|
1.0
|
C
|
C:GLN196
|
3.4
|
22.1
|
1.0
|
C
|
C:VAL40
|
3.5
|
24.6
|
1.0
|
N
|
C:VAL40
|
3.6
|
23.3
|
1.0
|
CG
|
C:ASP109
|
3.6
|
28.4
|
1.0
|
C
|
C:ASP109
|
3.7
|
25.1
|
1.0
|
CA
|
C:VAL40
|
4.0
|
24.9
|
1.0
|
CA
|
C:ASP109
|
4.0
|
24.8
|
1.0
|
CA
|
C:GLN196
|
4.1
|
21.6
|
1.0
|
CD
|
C:PRO42
|
4.3
|
21.5
|
1.0
|
CB
|
C:ASP109
|
4.4
|
24.1
|
1.0
|
C
|
C:THR39
|
4.4
|
25.1
|
1.0
|
OD2
|
C:ASP109
|
4.4
|
26.4
|
1.0
|
CB
|
C:THR39
|
4.4
|
30.0
|
1.0
|
O
|
C:HOH3863
|
4.4
|
38.2
|
1.0
|
N
|
C:THR197
|
4.5
|
18.8
|
1.0
|
CB
|
C:GLN196
|
4.6
|
26.1
|
1.0
|
N
|
C:ASN41
|
4.6
|
23.1
|
1.0
|
CB
|
C:VAL40
|
4.7
|
22.7
|
1.0
|
CA
|
C:THR39
|
4.7
|
25.2
|
1.0
|
CD1
|
C:ILE48
|
4.7
|
23.8
|
1.0
|
CA
|
C:THR197
|
4.8
|
20.0
|
1.0
|
CG2
|
C:THR197
|
4.8
|
16.6
|
1.0
|
N
|
C:ASN110
|
4.9
|
24.8
|
1.0
|
O
|
C:VAL345
|
5.0
|
20.2
|
1.0
|
|
Sodium binding site 4 out
of 12 in 1zum
Go back to
Sodium Binding Sites List in 1zum
Sodium binding site 4 out
of 12 in the Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form
Mono view
Stereo pair view
|
A full contact list of Sodium with other atoms in the Na binding
site number 4 of Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Na3704
b:55.6
occ:1.00
|
O
|
D:VAL40
|
2.4
|
51.6
|
1.0
|
O
|
D:GLN196
|
2.4
|
50.0
|
1.0
|
O
|
D:ASP109
|
2.5
|
35.9
|
1.0
|
OD1
|
D:ASP109
|
2.5
|
45.1
|
1.0
|
O
|
D:HOH3840
|
2.6
|
59.8
|
1.0
|
O
|
D:HOH3796
|
3.0
|
56.5
|
1.0
|
CG
|
D:ASP109
|
3.4
|
48.3
|
1.0
|
OG1
|
D:THR39
|
3.4
|
50.4
|
1.0
|
C
|
D:ASP109
|
3.5
|
40.2
|
1.0
|
C
|
D:VAL40
|
3.5
|
50.2
|
1.0
|
C
|
D:GLN196
|
3.6
|
49.0
|
1.0
|
N
|
D:VAL40
|
3.8
|
50.7
|
1.0
|
CA
|
D:ASP109
|
3.9
|
42.5
|
1.0
|
CD
|
D:PRO42
|
4.1
|
57.5
|
1.0
|
CA
|
D:VAL40
|
4.2
|
50.9
|
1.0
|
OD2
|
D:ASP109
|
4.2
|
47.5
|
1.0
|
CA
|
D:GLN196
|
4.2
|
48.3
|
1.0
|
CG
|
D:PRO42
|
4.2
|
58.0
|
1.0
|
CB
|
D:ASP109
|
4.2
|
43.3
|
1.0
|
C
|
D:THR39
|
4.5
|
50.3
|
1.0
|
N
|
D:ASN41
|
4.6
|
50.0
|
1.0
|
N
|
D:THR197
|
4.6
|
46.7
|
1.0
|
N
|
D:ASN110
|
4.7
|
38.7
|
1.0
|
CB
|
D:GLN196
|
4.7
|
48.7
|
1.0
|
CB
|
D:THR39
|
4.7
|
50.3
|
1.0
|
CG2
|
D:THR197
|
4.8
|
46.3
|
1.0
|
O
|
D:VAL345
|
4.8
|
50.5
|
1.0
|
CA
|
D:THR39
|
4.9
|
51.2
|
1.0
|
CA
|
D:THR197
|
4.9
|
47.4
|
1.0
|
CD1
|
D:ILE48
|
4.9
|
55.2
|
1.0
|
CB
|
D:VAL40
|
4.9
|
51.9
|
1.0
|
CA
|
D:ASN41
|
4.9
|
50.6
|
1.0
|
|
Sodium binding site 5 out
of 12 in 1zum
Go back to
Sodium Binding Sites List in 1zum
Sodium binding site 5 out
of 12 in the Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form
Mono view
Stereo pair view
|
A full contact list of Sodium with other atoms in the Na binding
site number 5 of Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:Na3705
b:28.5
occ:1.00
|
O
|
E:GLN196
|
2.4
|
24.7
|
1.0
|
O
|
E:HOH3904
|
2.4
|
34.2
|
1.0
|
O
|
E:VAL40
|
2.4
|
27.6
|
1.0
|
O
|
E:ASP109
|
2.4
|
24.9
|
1.0
|
OD1
|
E:ASP109
|
2.5
|
28.1
|
1.0
|
OG1
|
E:THR39
|
3.2
|
35.1
|
1.0
|
O
|
E:HOH3835
|
3.2
|
39.3
|
1.0
|
C
|
E:ASP109
|
3.4
|
20.9
|
1.0
|
CG
|
E:ASP109
|
3.4
|
28.7
|
1.0
|
C
|
E:VAL40
|
3.5
|
30.9
|
1.0
|
C
|
E:GLN196
|
3.5
|
26.2
|
1.0
|
CA
|
E:ASP109
|
3.7
|
21.6
|
1.0
|
N
|
E:VAL40
|
3.7
|
29.6
|
1.0
|
CB
|
E:ASP109
|
4.1
|
24.1
|
1.0
|
CA
|
E:VAL40
|
4.1
|
29.0
|
1.0
|
OD2
|
E:ASP109
|
4.2
|
26.9
|
1.0
|
CA
|
E:GLN196
|
4.2
|
23.7
|
1.0
|
CD
|
E:PRO42
|
4.2
|
28.6
|
1.0
|
C
|
E:THR39
|
4.4
|
28.7
|
1.0
|
CB
|
E:THR39
|
4.5
|
30.9
|
1.0
|
N
|
E:ASN41
|
4.5
|
27.3
|
1.0
|
N
|
E:THR197
|
4.6
|
22.6
|
1.0
|
N
|
E:ASN110
|
4.6
|
21.9
|
1.0
|
CD1
|
E:ILE48
|
4.6
|
26.7
|
1.0
|
CG2
|
E:THR197
|
4.7
|
18.7
|
1.0
|
CA
|
E:THR197
|
4.7
|
24.3
|
1.0
|
CB
|
E:GLN196
|
4.7
|
23.5
|
1.0
|
CA
|
E:THR39
|
4.7
|
28.8
|
1.0
|
CA
|
E:ASN41
|
4.9
|
26.8
|
1.0
|
CB
|
E:VAL40
|
4.9
|
32.9
|
1.0
|
|
Sodium binding site 6 out
of 12 in 1zum
Go back to
Sodium Binding Sites List in 1zum
Sodium binding site 6 out
of 12 in the Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form
Mono view
Stereo pair view
|
A full contact list of Sodium with other atoms in the Na binding
site number 6 of Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
F:Na3706
b:25.1
occ:1.00
|
O
|
F:VAL40
|
2.3
|
20.8
|
1.0
|
O
|
F:GLN196
|
2.4
|
19.2
|
1.0
|
OD1
|
F:ASP109
|
2.4
|
20.1
|
1.0
|
O
|
F:ASP109
|
2.5
|
23.3
|
1.0
|
O
|
F:HOH3794
|
2.6
|
29.9
|
1.0
|
O
|
F:HOH3883
|
2.8
|
33.5
|
1.0
|
OG1
|
F:THR39
|
3.0
|
26.7
|
1.0
|
CG
|
F:ASP109
|
3.4
|
18.6
|
1.0
|
C
|
F:VAL40
|
3.4
|
20.3
|
1.0
|
C
|
F:ASP109
|
3.5
|
17.9
|
1.0
|
C
|
F:GLN196
|
3.6
|
18.3
|
1.0
|
N
|
F:VAL40
|
3.7
|
20.9
|
1.0
|
CA
|
F:ASP109
|
3.8
|
16.7
|
1.0
|
CA
|
F:VAL40
|
4.1
|
20.4
|
1.0
|
CB
|
F:ASP109
|
4.2
|
14.8
|
1.0
|
OD2
|
F:ASP109
|
4.2
|
18.8
|
1.0
|
CA
|
F:GLN196
|
4.3
|
19.0
|
1.0
|
CB
|
F:THR39
|
4.3
|
27.0
|
1.0
|
CD
|
F:PRO42
|
4.3
|
16.6
|
1.0
|
C
|
F:THR39
|
4.4
|
21.4
|
1.0
|
O
|
F:HOH3921
|
4.4
|
39.3
|
1.0
|
N
|
F:ASN41
|
4.5
|
18.3
|
1.0
|
N
|
F:THR197
|
4.6
|
17.9
|
1.0
|
CD1
|
F:ILE48
|
4.6
|
18.7
|
1.0
|
CA
|
F:THR39
|
4.7
|
21.3
|
1.0
|
CB
|
F:GLN196
|
4.7
|
25.1
|
1.0
|
N
|
F:ASN110
|
4.7
|
18.9
|
1.0
|
CA
|
F:THR197
|
4.8
|
17.3
|
1.0
|
CB
|
F:VAL40
|
4.8
|
19.1
|
1.0
|
CG2
|
F:THR197
|
4.8
|
10.8
|
1.0
|
CA
|
F:ASN41
|
4.9
|
20.4
|
1.0
|
CG2
|
F:THR39
|
5.0
|
23.3
|
1.0
|
|
Sodium binding site 7 out
of 12 in 1zum
Go back to
Sodium Binding Sites List in 1zum
Sodium binding site 7 out
of 12 in the Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form
Mono view
Stereo pair view
|
A full contact list of Sodium with other atoms in the Na binding
site number 7 of Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
G:Na3707
b:37.1
occ:1.00
|
O
|
G:GLN196
|
2.3
|
29.4
|
1.0
|
O
|
G:VAL40
|
2.4
|
38.4
|
1.0
|
O
|
G:ASP109
|
2.5
|
30.9
|
1.0
|
OD1
|
G:ASP109
|
2.6
|
39.3
|
1.0
|
O
|
G:HOH3949
|
2.6
|
42.8
|
1.0
|
OG1
|
G:THR39
|
3.0
|
39.5
|
1.0
|
C
|
G:ASP109
|
3.5
|
32.3
|
1.0
|
CG
|
G:ASP109
|
3.5
|
35.8
|
1.0
|
C
|
G:GLN196
|
3.5
|
33.3
|
1.0
|
C
|
G:VAL40
|
3.5
|
37.5
|
1.0
|
N
|
G:VAL40
|
3.7
|
37.0
|
1.0
|
CA
|
G:ASP109
|
3.8
|
30.5
|
1.0
|
CA
|
G:VAL40
|
4.1
|
36.8
|
1.0
|
CB
|
G:ASP109
|
4.2
|
33.3
|
1.0
|
CA
|
G:GLN196
|
4.2
|
32.5
|
1.0
|
CD
|
G:PRO42
|
4.3
|
34.7
|
1.0
|
OD2
|
G:ASP109
|
4.3
|
37.0
|
1.0
|
CB
|
G:THR39
|
4.3
|
42.9
|
1.0
|
C
|
G:THR39
|
4.3
|
40.6
|
1.0
|
N
|
G:THR197
|
4.5
|
30.9
|
1.0
|
N
|
G:ASN41
|
4.6
|
31.2
|
1.0
|
CA
|
G:THR39
|
4.7
|
41.3
|
1.0
|
CA
|
G:THR197
|
4.7
|
31.1
|
1.0
|
N
|
G:ASN110
|
4.7
|
32.0
|
1.0
|
CG2
|
G:THR197
|
4.7
|
27.6
|
1.0
|
CB
|
G:GLN196
|
4.7
|
32.6
|
1.0
|
CD1
|
G:ILE48
|
4.7
|
38.3
|
1.0
|
CB
|
G:VAL40
|
4.9
|
35.6
|
1.0
|
CA
|
G:ASN41
|
4.9
|
33.4
|
1.0
|
|
Sodium binding site 8 out
of 12 in 1zum
Go back to
Sodium Binding Sites List in 1zum
Sodium binding site 8 out
of 12 in the Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form
Mono view
Stereo pair view
|
A full contact list of Sodium with other atoms in the Na binding
site number 8 of Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
H:Na3708
b:36.0
occ:1.00
|
O
|
H:GLN196
|
2.3
|
27.4
|
1.0
|
O
|
H:ASP109
|
2.4
|
24.2
|
1.0
|
O
|
H:VAL40
|
2.4
|
36.6
|
1.0
|
OD1
|
H:ASP109
|
2.5
|
35.4
|
1.0
|
O
|
H:HOH3910
|
2.5
|
57.2
|
1.0
|
OG1
|
H:THR39
|
3.2
|
32.8
|
1.0
|
O
|
H:HOH3861
|
3.3
|
48.5
|
1.0
|
CG
|
H:ASP109
|
3.4
|
31.7
|
1.0
|
C
|
H:ASP109
|
3.4
|
27.0
|
1.0
|
C
|
H:GLN196
|
3.5
|
30.3
|
1.0
|
C
|
H:VAL40
|
3.6
|
37.4
|
1.0
|
CA
|
H:ASP109
|
3.8
|
26.2
|
1.0
|
N
|
H:VAL40
|
3.8
|
36.0
|
1.0
|
OD2
|
H:ASP109
|
4.1
|
33.6
|
1.0
|
CD
|
H:PRO42
|
4.1
|
37.7
|
1.0
|
CB
|
H:ASP109
|
4.2
|
26.6
|
1.0
|
CA
|
H:GLN196
|
4.2
|
30.5
|
1.0
|
CA
|
H:VAL40
|
4.2
|
37.3
|
1.0
|
CB
|
H:THR39
|
4.5
|
36.6
|
1.0
|
C
|
H:THR39
|
4.5
|
35.8
|
1.0
|
N
|
H:THR197
|
4.5
|
28.7
|
1.0
|
N
|
H:ASN110
|
4.6
|
26.6
|
1.0
|
N
|
H:ASN41
|
4.6
|
34.1
|
1.0
|
CG2
|
H:THR197
|
4.7
|
21.7
|
1.0
|
CB
|
H:GLN196
|
4.7
|
32.7
|
1.0
|
CA
|
H:THR197
|
4.7
|
27.5
|
1.0
|
CD1
|
H:ILE48
|
4.8
|
33.5
|
1.0
|
CA
|
H:THR39
|
4.8
|
35.4
|
1.0
|
O
|
H:VAL345
|
4.9
|
36.2
|
1.0
|
CA
|
H:ASN41
|
5.0
|
31.8
|
1.0
|
CB
|
H:VAL40
|
5.0
|
36.1
|
1.0
|
|
Sodium binding site 9 out
of 12 in 1zum
Go back to
Sodium Binding Sites List in 1zum
Sodium binding site 9 out
of 12 in the Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form
Mono view
Stereo pair view
|
A full contact list of Sodium with other atoms in the Na binding
site number 9 of Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
I:Na3709
b:36.2
occ:1.00
|
O
|
I:GLN196
|
2.4
|
33.9
|
1.0
|
O
|
I:VAL40
|
2.4
|
30.1
|
1.0
|
O
|
I:ASP109
|
2.5
|
28.2
|
1.0
|
OD1
|
I:ASP109
|
2.6
|
35.8
|
1.0
|
O
|
I:HOH3833
|
2.7
|
62.9
|
1.0
|
O
|
I:HOH3832
|
2.9
|
50.2
|
1.0
|
OG1
|
I:THR39
|
3.1
|
25.1
|
1.0
|
CG
|
I:ASP109
|
3.4
|
32.4
|
1.0
|
C
|
I:ASP109
|
3.4
|
28.1
|
1.0
|
C
|
I:VAL40
|
3.5
|
30.9
|
1.0
|
C
|
I:GLN196
|
3.5
|
33.2
|
1.0
|
N
|
I:VAL40
|
3.7
|
28.8
|
1.0
|
CA
|
I:ASP109
|
3.8
|
28.7
|
1.0
|
CA
|
I:VAL40
|
4.1
|
29.9
|
1.0
|
CB
|
I:ASP109
|
4.2
|
30.9
|
1.0
|
OD2
|
I:ASP109
|
4.2
|
30.1
|
1.0
|
CA
|
I:GLN196
|
4.2
|
35.0
|
1.0
|
CD
|
I:PRO42
|
4.3
|
28.6
|
1.0
|
CB
|
I:THR39
|
4.4
|
29.7
|
1.0
|
C
|
I:THR39
|
4.4
|
29.8
|
1.0
|
N
|
I:THR197
|
4.6
|
32.3
|
1.0
|
N
|
I:ASN41
|
4.6
|
28.9
|
1.0
|
CD1
|
I:ILE48
|
4.6
|
22.9
|
1.0
|
N
|
I:ASN110
|
4.6
|
26.1
|
1.0
|
CA
|
I:THR39
|
4.7
|
27.9
|
1.0
|
CG2
|
I:THR197
|
4.7
|
32.9
|
1.0
|
CB
|
I:GLN196
|
4.7
|
31.1
|
1.0
|
CA
|
I:THR197
|
4.7
|
28.7
|
1.0
|
CB
|
I:VAL40
|
4.9
|
33.1
|
1.0
|
CA
|
I:ASN41
|
5.0
|
28.6
|
1.0
|
|
Sodium binding site 10 out
of 12 in 1zum
Go back to
Sodium Binding Sites List in 1zum
Sodium binding site 10 out
of 12 in the Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form
Mono view
Stereo pair view
|
A full contact list of Sodium with other atoms in the Na binding
site number 10 of Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, Apo Form within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
J:Na3710
b:48.1
occ:1.00
|
O
|
J:ASP109
|
2.4
|
39.0
|
1.0
|
O
|
J:GLN196
|
2.4
|
50.6
|
1.0
|
O
|
J:VAL40
|
2.4
|
50.4
|
1.0
|
OD1
|
J:ASP109
|
2.5
|
47.0
|
1.0
|
O
|
J:HOH3781
|
2.8
|
45.5
|
1.0
|
C
|
J:ASP109
|
3.4
|
42.8
|
1.0
|
CG
|
J:ASP109
|
3.5
|
46.2
|
1.0
|
OG1
|
J:THR39
|
3.5
|
56.2
|
1.0
|
C
|
J:GLN196
|
3.6
|
48.6
|
1.0
|
C
|
J:VAL40
|
3.6
|
50.5
|
1.0
|
CA
|
J:ASP109
|
3.9
|
43.6
|
1.0
|
N
|
J:VAL40
|
3.9
|
51.4
|
1.0
|
CD
|
J:PRO42
|
4.1
|
45.1
|
1.0
|
CA
|
J:GLN196
|
4.2
|
50.1
|
1.0
|
CB
|
J:ASP109
|
4.2
|
44.0
|
1.0
|
CA
|
J:VAL40
|
4.3
|
50.3
|
1.0
|
OD2
|
J:ASP109
|
4.3
|
46.6
|
1.0
|
N
|
J:ASN110
|
4.6
|
43.8
|
1.0
|
CG2
|
J:THR197
|
4.6
|
41.7
|
1.0
|
CB
|
J:GLN196
|
4.6
|
49.0
|
1.0
|
N
|
J:THR197
|
4.6
|
45.1
|
1.0
|
N
|
J:ASN41
|
4.7
|
49.2
|
1.0
|
C
|
J:THR39
|
4.7
|
53.8
|
1.0
|
O
|
J:VAL345
|
4.7
|
39.8
|
1.0
|
CB
|
J:THR39
|
4.8
|
55.2
|
1.0
|
CA
|
J:THR197
|
4.9
|
42.2
|
1.0
|
N
|
J:PRO42
|
4.9
|
47.5
|
1.0
|
CA
|
J:ASN41
|
4.9
|
49.0
|
1.0
|
CB
|
J:VAL40
|
5.0
|
52.2
|
1.0
|
|
Reference:
H.N.Larson,
H.Weiner,
T.D.Hurley.
Disruption of the Coenzyme Binding Site and Dimer Interface Revealed in the Crystal Structure of Mitochondrial Aldehyde Dehydrogenase "Asian" Variant J.Biol.Chem. V. 280 30550 2005.
ISSN: ISSN 0021-9258
PubMed: 15983043
DOI: 10.1074/JBC.M502345200
Page generated: Mon Oct 7 01:45:41 2024
|