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Sodium in PDB 1zoh: Crystal Structure of Protein Kinase CK2 in Complex with Tbb- Derivatives Inhibitors

Enzymatic activity of Crystal Structure of Protein Kinase CK2 in Complex with Tbb- Derivatives Inhibitors

All present enzymatic activity of Crystal Structure of Protein Kinase CK2 in Complex with Tbb- Derivatives Inhibitors:
2.7.1.37;

Protein crystallography data

The structure of Crystal Structure of Protein Kinase CK2 in Complex with Tbb- Derivatives Inhibitors, PDB code: 1zoh was solved by R.Battistutta, M.Mazzorana, S.Sarno, Z.Kazimierczuk, G.Zanotti, L.A.Pinna, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.39 / 1.81
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 143.560, 61.090, 44.690, 90.00, 102.70, 90.00
R / Rfree (%) 16.5 / 22.1

Other elements in 1zoh:

The structure of Crystal Structure of Protein Kinase CK2 in Complex with Tbb- Derivatives Inhibitors also contains other interesting chemical elements:

Bromine (Br) 4 atoms
Chlorine (Cl) 2 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure of Protein Kinase CK2 in Complex with Tbb- Derivatives Inhibitors (pdb code 1zoh). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of Protein Kinase CK2 in Complex with Tbb- Derivatives Inhibitors, PDB code: 1zoh:

Sodium binding site 1 out of 1 in 1zoh

Go back to Sodium Binding Sites List in 1zoh
Sodium binding site 1 out of 1 in the Crystal Structure of Protein Kinase CK2 in Complex with Tbb- Derivatives Inhibitors


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of Protein Kinase CK2 in Complex with Tbb- Derivatives Inhibitors within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na601

b:13.7
occ:1.00
OD1 A:ASP175 2.8 23.1 1.0
N A:ASP175 3.1 8.0 1.0
O A:HOH1043 3.1 13.3 1.0
BR11 A:K44501 3.2 29.7 1.0
CZ A:PHE113 3.5 11.8 1.0
CA A:ASP175 3.5 14.0 1.0
CE2 A:PHE113 3.7 14.3 1.0
CB A:ILE174 3.9 14.5 1.0
CE1 A:PHE113 3.9 10.7 1.0
CG A:ASP175 3.9 27.3 1.0
BR10 A:K44501 3.9 27.9 1.0
CD A:LYS68 3.9 24.4 1.0
C A:ILE174 4.1 7.2 1.0
CD2 A:PHE113 4.2 18.6 1.0
CA A:ILE174 4.3 6.1 1.0
NZ A:LYS68 4.3 25.5 1.0
CB A:ASP175 4.3 12.9 1.0
CD1 A:PHE113 4.4 15.0 1.0
CG1 A:VAL95 4.4 9.5 1.0
C1 A:K44501 4.5 16.4 1.0
CG A:PHE113 4.6 13.6 1.0
CD1 A:ILE174 4.6 9.8 1.0
CG1 A:ILE174 4.7 10.6 1.0
CG2 A:ILE174 4.7 6.7 1.0
CE A:LYS68 4.7 37.0 1.0
C A:ASP175 4.7 9.0 1.0
C4 A:K44501 4.8 14.1 1.0
N A:TRP176 4.8 12.0 1.0
O A:HOH1063 4.8 16.4 1.0
OD2 A:ASP175 5.0 27.5 1.0
CG A:LYS68 5.0 29.4 1.0

Reference:

R.Battistutta, M.Mazzorana, S.Sarno, Z.Kazimierczuk, G.Zanotti, L.A.Pinna. Inspecting the Structure-Activity Relationship of Protein Kinase CK2 Inhibitors Derived From Tetrabromo-Benzimidazole. Chem.Biol. V. 12 1211 2005.
ISSN: ISSN 1074-5521
PubMed: 16298300
DOI: 10.1016/J.CHEMBIOL.2005.08.015
Page generated: Tue Dec 15 05:44:38 2020

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