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PDB 1w5n-1x7d »
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Sodium in PDB 1x70: Human Dipeptidyl Peptidase IV in Complex with A Beta Amino Acid Inhibitor
Enzymatic activity of Human Dipeptidyl Peptidase IV in Complex with A Beta Amino Acid Inhibitor
All present enzymatic activity of Human Dipeptidyl Peptidase IV in Complex with A Beta Amino Acid Inhibitor:
3.4.14.5;
3.4.14.5;
Protein crystallography data
The structure of Human Dipeptidyl Peptidase IV in Complex with A Beta Amino Acid Inhibitor, PDB code: 1x70
was solved by
D.Kim,
L.Wang,
M.Beconi,
G.J.Eiermann,
M.H.Fisher,
H.He,
G.J.Hickey,
B.Leiting,
K.Lyons,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 30.00 / 2.10 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 118.253, 125.680, 137.206, 90.00, 90.00, 90.00 |
| R / Rfree (%) | n/a / n/a |
Other elements in 1x70:
The structure of Human Dipeptidyl Peptidase IV in Complex with A Beta Amino Acid Inhibitor also contains other interesting chemical elements:
| Fluorine | (F) | 12 atoms |
Sodium Binding Sites:
The binding sites of Sodium atom in the Human Dipeptidyl Peptidase IV in Complex with A Beta Amino Acid Inhibitor
(pdb code 1x70). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Human Dipeptidyl Peptidase IV in Complex with A Beta Amino Acid Inhibitor, PDB code: 1x70:
In total only one binding site of Sodium was determined in the Human Dipeptidyl Peptidase IV in Complex with A Beta Amino Acid Inhibitor, PDB code: 1x70:
Sodium binding site 1 out of 1 in 1x70
Go back to
Sodium Binding Sites List in 1x70
Sodium binding site 1 out
of 1 in the Human Dipeptidyl Peptidase IV in Complex with A Beta Amino Acid Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Sodium with other atoms in the Na binding
site number 1 of Human Dipeptidyl Peptidase IV in Complex with A Beta Amino Acid Inhibitor within 5.0Å range:
|
Reference:
D.Kim,
L.Wang,
M.Beconi,
G.J.Eiermann,
M.H.Fisher,
H.He,
G.J.Hickey,
J.E.Kowalchick,
B.Leiting,
K.Lyons,
F.Marsilio,
M.E.Mccann,
R.A.Patel,
A.Petrov,
G.Scapin,
S.B.Patel,
R.S.Roy,
J.K.Wu,
M.J.Wyvratt,
B.B.Zhang,
L.Zhu,
N.A.Thornberry,
A.E.Weber.
(2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-Dihydro[1,2, 4]Triazolo[4,3-A]Pyrazin- 7(8H)-Yl]-1-(2,4,5-Trifluorophenyl)Butan-2-Amine: A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor For the Treatment of Type 2 Diabetes J.Med.Chem. V. 48 141 2005.
ISSN: ISSN 0022-2623
PubMed: 15634008
DOI: 10.1021/JM0493156
Page generated: Mon Oct 7 00:30:14 2024
ISSN: ISSN 0022-2623
PubMed: 15634008
DOI: 10.1021/JM0493156
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