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Sodium in PDB 1tbz: Human Thrombin with Active Site N-Methyl-D Phenylalanyl-N-[5- (Aminoiminomethyl)Amino]-1-{{Benzothiazolyl)Carbonyl] Butyl]-L- Prolinamide Trifluroacetate and Exosite-Hirugen
Enzymatic activity of Human Thrombin with Active Site N-Methyl-D Phenylalanyl-N-[5- (Aminoiminomethyl)Amino]-1-{{Benzothiazolyl)Carbonyl] Butyl]-L- Prolinamide Trifluroacetate and Exosite-Hirugen
All present enzymatic activity of Human Thrombin with Active Site N-Methyl-D Phenylalanyl-N-[5- (Aminoiminomethyl)Amino]-1-{{Benzothiazolyl)Carbonyl] Butyl]-L- Prolinamide Trifluroacetate and Exosite-Hirugen:
3.4.21.5;
3.4.21.5;
Protein crystallography data
The structure of Human Thrombin with Active Site N-Methyl-D Phenylalanyl-N-[5- (Aminoiminomethyl)Amino]-1-{{Benzothiazolyl)Carbonyl] Butyl]-L- Prolinamide Trifluroacetate and Exosite-Hirugen, PDB code: 1tbz
was solved by
J.H.Matthews,
R.Krishnan,
M.J.Costanzo,
B.E.Maryanoff,
A.Tulinsky,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 7.00 / 2.30 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 70.790, 72.530, 73.120, 90.00, 101.00, 90.00 |
| R / Rfree (%) | 15.8 / n/a |
Sodium Binding Sites:
The binding sites of Sodium atom in the Human Thrombin with Active Site N-Methyl-D Phenylalanyl-N-[5- (Aminoiminomethyl)Amino]-1-{{Benzothiazolyl)Carbonyl] Butyl]-L- Prolinamide Trifluroacetate and Exosite-Hirugen
(pdb code 1tbz). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Human Thrombin with Active Site N-Methyl-D Phenylalanyl-N-[5- (Aminoiminomethyl)Amino]-1-{{Benzothiazolyl)Carbonyl] Butyl]-L- Prolinamide Trifluroacetate and Exosite-Hirugen, PDB code: 1tbz:
Jump to Sodium binding site number: 1; 2;
In total 2 binding sites of Sodium where determined in the Human Thrombin with Active Site N-Methyl-D Phenylalanyl-N-[5- (Aminoiminomethyl)Amino]-1-{{Benzothiazolyl)Carbonyl] Butyl]-L- Prolinamide Trifluroacetate and Exosite-Hirugen, PDB code: 1tbz:
Jump to Sodium binding site number: 1; 2;
Sodium binding site 1 out of 2 in 1tbz
Go back to
Sodium Binding Sites List in 1tbz
Sodium binding site 1 out
of 2 in the Human Thrombin with Active Site N-Methyl-D Phenylalanyl-N-[5- (Aminoiminomethyl)Amino]-1-{{Benzothiazolyl)Carbonyl] Butyl]-L- Prolinamide Trifluroacetate and Exosite-Hirugen
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Sodium with other atoms in the Na binding
site number 1 of Human Thrombin with Active Site N-Methyl-D Phenylalanyl-N-[5- (Aminoiminomethyl)Amino]-1-{{Benzothiazolyl)Carbonyl] Butyl]-L- Prolinamide Trifluroacetate and Exosite-Hirugen within 5.0Å range:
|
Sodium binding site 2 out of 2 in 1tbz
Go back to
Sodium Binding Sites List in 1tbz
Sodium binding site 2 out
of 2 in the Human Thrombin with Active Site N-Methyl-D Phenylalanyl-N-[5- (Aminoiminomethyl)Amino]-1-{{Benzothiazolyl)Carbonyl] Butyl]-L- Prolinamide Trifluroacetate and Exosite-Hirugen
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Sodium with other atoms in the Na binding
site number 2 of Human Thrombin with Active Site N-Methyl-D Phenylalanyl-N-[5- (Aminoiminomethyl)Amino]-1-{{Benzothiazolyl)Carbonyl] Butyl]-L- Prolinamide Trifluroacetate and Exosite-Hirugen within 5.0Å range:
|
Reference:
J.H.Matthews,
R.Krishnan,
M.J.Costanzo,
B.E.Maryanoff,
A.Tulinsky.
Crystal Structures of Thrombin with Thiazole-Containing Inhibitors: Probes of the S1' Binding Site. Biophys.J. V. 71 2830 1996.
ISSN: ISSN 0006-3495
PubMed: 8913620
Page generated: Sun Oct 6 22:38:30 2024
ISSN: ISSN 0006-3495
PubMed: 8913620
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