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Sodium in PDB 1scn: Inactivation of Subtilisin Carlsberg By N-(Tert-Butoxycarbonyl-Alanyl- Prolyl-Phenylalanyl)-O-Benzol Hydroxylamine: Formation of Covalent Enzyme-Inhibitor Linkage in the Form of A Carbamate Derivative

Enzymatic activity of Inactivation of Subtilisin Carlsberg By N-(Tert-Butoxycarbonyl-Alanyl- Prolyl-Phenylalanyl)-O-Benzol Hydroxylamine: Formation of Covalent Enzyme-Inhibitor Linkage in the Form of A Carbamate Derivative

All present enzymatic activity of Inactivation of Subtilisin Carlsberg By N-(Tert-Butoxycarbonyl-Alanyl- Prolyl-Phenylalanyl)-O-Benzol Hydroxylamine: Formation of Covalent Enzyme-Inhibitor Linkage in the Form of A Carbamate Derivative:
3.4.21.62;

Protein crystallography data

The structure of Inactivation of Subtilisin Carlsberg By N-(Tert-Butoxycarbonyl-Alanyl- Prolyl-Phenylalanyl)-O-Benzol Hydroxylamine: Formation of Covalent Enzyme-Inhibitor Linkage in the Form of A Carbamate Derivative, PDB code: 1scn was solved by A.C.U.Steinmetz, H.-U.Demuth, D.Ringe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 1.90
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 76.500, 55.400, 53.400, 90.00, 90.00, 90.00
R / Rfree (%) n/a / n/a

Other elements in 1scn:

The structure of Inactivation of Subtilisin Carlsberg By N-(Tert-Butoxycarbonyl-Alanyl- Prolyl-Phenylalanyl)-O-Benzol Hydroxylamine: Formation of Covalent Enzyme-Inhibitor Linkage in the Form of A Carbamate Derivative also contains other interesting chemical elements:

Calcium (Ca) 2 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Inactivation of Subtilisin Carlsberg By N-(Tert-Butoxycarbonyl-Alanyl- Prolyl-Phenylalanyl)-O-Benzol Hydroxylamine: Formation of Covalent Enzyme-Inhibitor Linkage in the Form of A Carbamate Derivative (pdb code 1scn). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Inactivation of Subtilisin Carlsberg By N-(Tert-Butoxycarbonyl-Alanyl- Prolyl-Phenylalanyl)-O-Benzol Hydroxylamine: Formation of Covalent Enzyme-Inhibitor Linkage in the Form of A Carbamate Derivative, PDB code: 1scn:

Sodium binding site 1 out of 1 in 1scn

Go back to Sodium Binding Sites List in 1scn
Sodium binding site 1 out of 1 in the Inactivation of Subtilisin Carlsberg By N-(Tert-Butoxycarbonyl-Alanyl- Prolyl-Phenylalanyl)-O-Benzol Hydroxylamine: Formation of Covalent Enzyme-Inhibitor Linkage in the Form of A Carbamate Derivative


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Inactivation of Subtilisin Carlsberg By N-(Tert-Butoxycarbonyl-Alanyl- Prolyl-Phenylalanyl)-O-Benzol Hydroxylamine: Formation of Covalent Enzyme-Inhibitor Linkage in the Form of A Carbamate Derivative within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Na402

b:47.5
occ:1.00
 O E:GLU195 2.8 19.0 1.0
OE1 E:GLU197 3.0 14.8 1.0
O E:VAL174 3.1 16.6 1.0
N E:ALA176 3.2 20.0 1.0
CB E:ALA176 3.2 18.4 1.0
O E:HOH673 3.4 24.8 1.0
O E:HOH576 3.6 34.0 1.0
CB E:GLU197 3.7 15.9 1.0
O E:ALA169 3.9 16.1 1.0
CA E:ALA176 3.9 18.2 1.0
C E:GLU195 3.9 19.9 1.0
O E:HOH892 4.1 48.1 1.0
C E:ILE175 4.1 19.1 1.0
CD E:GLU197 4.1 24.0 1.0
CA E:ILE175 4.1 18.4 1.0
CB E:GLU195 4.2 18.4 1.0
NH2 E:ARG247 4.3 20.7 1.0
C E:VAL174 4.3 17.5 1.0
CG E:GLU197 4.4 13.7 1.0
N E:GLU197 4.5 16.4 1.0
CA E:GLU195 4.6 18.7 1.0
O E:TYR171 4.7 18.5 1.0
CA E:GLU197 4.7 16.2 1.0
N E:ILE175 4.8 17.6 1.0
O E:ALA176 4.8 14.8 1.0
C E:LEU196 4.8 17.8 1.0
C E:ALA176 4.9 16.1 1.0
C E:ALA169 5.0 17.0 1.0
N E:LEU196 5.0 20.7 1.0

Reference:

A.C.Steinmetz, H.U.Demuth, D.Ringe. Inactivation of Subtilisin Carlsberg By N-((Tert-Butoxycarbonyl)Alanylprolylphenylalanyl) -O-Benzolhydroxyl- Amine: Formation of A Covalent Enzyme-Inhibitor Linkage in the Form of A Carbamate Derivative. Biochemistry V. 33 10535 1994.
ISSN: ISSN 0006-2960
PubMed: 8068694
DOI: 10.1021/BI00200A040
Page generated: Sun Oct 6 22:24:01 2024

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