Sodium in PDB 1q6x: Crystal Structure of Rat Choline Acetyltransferase

All present enzymatic activity of Crystal Structure of Rat Choline Acetyltransferase:
2.3.1.6;

The structure of Crystal Structure of Rat Choline Acetyltransferase, PDB code: 1q6x was solved by Y.Cai, D.W.Rodgers, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.94 / 2.50
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	84.701, 78.882, 139.364, 90.00, 98.38, 90.00
R / Rfree (%)	22.3 / 25.1

The binding sites of Sodium atom in the Crystal Structure of Rat Choline Acetyltransferase (pdb code 1q6x). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Crystal Structure of Rat Choline Acetyltransferase, PDB code: 1q6x:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Crystal Structure of Rat Choline Acetyltransferase


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of Rat Choline Acetyltransferase within 5.0Å range: probe atom residue distance (Å) B Occ A:Na1002 b:24.6 occ:1.00 O A:HOH1096 2.3 19.8 1.0 O A:THR594 2.3 27.8 1.0 O A:CYS591 2.6 34.1 1.0 O A:PHE588 2.6 21.3 1.0 O A:HOH1047 2.7 25.3 1.0 OG1 A:THR594 2.8 31.9 1.0 C A:THR594 3.2 29.9 1.0 C A:PHE588 3.4 21.1 1.0 CA A:HIS589 3.5 24.8 1.0 C A:CYS591 3.6 33.8 1.0 O A:HIS589 3.8 26.1 1.0 N A:HIS589 3.8 22.5 1.0 C A:HIS589 3.8 26.2 1.0 CA A:THR594 3.9 32.0 1.0 CB A:THR594 3.9 31.7 1.0 N A:THR594 4.0 34.4 1.0 N A:SER595 4.2 28.7 1.0 N A:CYS591 4.2 31.9 1.0 CA A:CYS591 4.3 33.0 1.0 CA A:SER595 4.5 29.5 1.0 CB A:CYS591 4.5 33.2 1.0 OG A:SER587 4.5 20.5 1.0 CA A:PHE588 4.6 19.7 1.0 N A:PHE588 4.6 19.4 1.0 N A:LYS592 4.6 35.7 1.0 OD2 A:ASP402 4.7 34.2 1.0 N A:SER590 4.7 27.6 1.0 CD2 A:HIS589 4.8 27.1 1.0 CB A:HIS589 4.8 25.8 1.0 CA A:LYS592 4.9 39.2 1.0 C A:LYS592 4.9 38.8 1.0 O A:LYS592 5.0 38.1 1.0

Sodium binding site 2 out of 2 in the Crystal Structure of Rat Choline Acetyltransferase


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Crystal Structure of Rat Choline Acetyltransferase within 5.0Å range: probe atom residue distance (Å) B Occ B:Na1001 b:21.4 occ:1.00 O B:HOH1045 2.3 20.3 1.0 O B:THR594 2.4 22.8 1.0 O B:PHE588 2.4 14.2 1.0 O B:CYS591 2.4 24.5 1.0 OG1 B:THR594 2.6 22.3 1.0 O B:HOH1018 2.8 25.2 1.0 C B:THR594 3.2 24.1 1.0 C B:PHE588 3.3 15.6 1.0 C B:CYS591 3.5 25.7 1.0 CA B:HIS589 3.6 19.4 1.0 CB B:THR594 3.7 24.8 1.0 N B:HIS589 3.8 16.7 1.0 CA B:THR594 3.8 25.5 1.0 C B:HIS589 3.8 20.4 1.0 O B:HIS589 3.8 17.9 1.0 N B:THR594 3.9 27.8 1.0 N B:CYS591 4.0 24.9 1.0 CA B:CYS591 4.2 24.6 1.0 N B:SER595 4.2 21.6 1.0 CB B:CYS591 4.2 25.7 1.0 OG B:SER587 4.4 14.3 1.0 CA B:PHE588 4.4 14.1 1.0 N B:PHE588 4.5 13.8 1.0 N B:LYS592 4.6 28.5 1.0 CA B:SER595 4.6 21.4 1.0 N B:SER590 4.7 21.9 1.0 O B:HOH1005 4.7 6.3 1.0 CG2 B:THR594 4.8 23.8 1.0 CA B:LYS592 4.8 32.3 1.0 C B:LYS592 4.8 32.4 1.0 OD2 B:ASP402 4.9 26.1 1.0 CB B:SER587 4.9 14.0 1.0 CB B:HIS589 4.9 20.7 1.0 CD2 B:HIS589 5.0 24.6 1.0

Y.Cai, C.N.Cronin, A.G.Engel, K.Ohno, L.B.Hersh, D.W.Rodgers. Choline Acetyltransferase Structure Reveals Distribution of Mutations That Cause Motor Disorders. Embo J. V. 23 2047 2004.
ISSN: ISSN 0261-4189
PubMed: 15131697
DOI: 10.1038/SJ.EMBOJ.7600221