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Sodium in PDB 1c9d: Crystal Structure of the Complex of Bacterial Tryptophan Synthase with the Transition State Analogue Inhibitor 4-(2-Hydroxy-4- Fluorophenylthio)-Butylphosphonic Acid

Enzymatic activity of Crystal Structure of the Complex of Bacterial Tryptophan Synthase with the Transition State Analogue Inhibitor 4-(2-Hydroxy-4- Fluorophenylthio)-Butylphosphonic Acid

All present enzymatic activity of Crystal Structure of the Complex of Bacterial Tryptophan Synthase with the Transition State Analogue Inhibitor 4-(2-Hydroxy-4- Fluorophenylthio)-Butylphosphonic Acid:
4.2.1.20;

Protein crystallography data

The structure of Crystal Structure of the Complex of Bacterial Tryptophan Synthase with the Transition State Analogue Inhibitor 4-(2-Hydroxy-4- Fluorophenylthio)-Butylphosphonic Acid, PDB code: 1c9d was solved by E.Lolis, A.Sachpatzidis, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 2.30
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 184.220, 60.520, 67.790, 90.00, 94.43, 90.00
R / Rfree (%) 21.1 / 26.9

Other elements in 1c9d:

The structure of Crystal Structure of the Complex of Bacterial Tryptophan Synthase with the Transition State Analogue Inhibitor 4-(2-Hydroxy-4- Fluorophenylthio)-Butylphosphonic Acid also contains other interesting chemical elements:

Fluorine (F) 1 atom

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure of the Complex of Bacterial Tryptophan Synthase with the Transition State Analogue Inhibitor 4-(2-Hydroxy-4- Fluorophenylthio)-Butylphosphonic Acid (pdb code 1c9d). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of the Complex of Bacterial Tryptophan Synthase with the Transition State Analogue Inhibitor 4-(2-Hydroxy-4- Fluorophenylthio)-Butylphosphonic Acid, PDB code: 1c9d:

Sodium binding site 1 out of 1 in 1c9d

Go back to Sodium Binding Sites List in 1c9d
Sodium binding site 1 out of 1 in the Crystal Structure of the Complex of Bacterial Tryptophan Synthase with the Transition State Analogue Inhibitor 4-(2-Hydroxy-4- Fluorophenylthio)-Butylphosphonic Acid


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of the Complex of Bacterial Tryptophan Synthase with the Transition State Analogue Inhibitor 4-(2-Hydroxy-4- Fluorophenylthio)-Butylphosphonic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Na1191

b:7.4
occ:1.00
 O B:HOH1131 2.3 18.4 1.0
O B:HOH1028 2.3 6.7 1.0
O B:PHE306 2.3 19.5 1.0
O B:GLY232 2.4 8.3 1.0
O B:SER308 2.5 10.5 1.0
C B:PHE306 3.5 19.5 1.0
C B:GLY232 3.6 7.0 1.0
C B:SER308 3.7 8.1 1.0
CG B:PRO270 3.9 7.1 1.0
N B:SER308 4.0 8.2 1.0
CD B:PRO270 4.0 11.1 1.0
CB B:PHE306 4.2 20.4 1.0
O B:GLY268 4.2 9.7 1.0
CA B:GLY232 4.2 5.4 1.0
CA B:PHE306 4.3 21.7 1.0
CD1 B:PHE306 4.4 15.3 1.0
O B:VAL231 4.4 5.5 1.0
N B:PRO307 4.4 17.4 1.0
CA B:SER308 4.5 9.4 1.0
C B:PRO307 4.5 11.4 1.0
OG B:SER297 4.6 24.8 1.0
N B:GLY233 4.6 5.5 1.0
N B:PHE306 4.6 25.1 1.0
CA B:PRO307 4.7 14.9 1.0
N B:VAL309 4.7 7.7 1.0
CG B:PHE306 4.7 19.2 1.0
CA B:VAL309 4.8 5.1 1.0
CB B:VAL309 4.8 7.5 1.0
O B:LEU304 4.9 20.4 1.0
OE2 B:GLU256 4.9 9.6 1.0
CA B:GLY233 4.9 4.0 1.0

Reference:

A.Sachpatzidis, C.Dealwis, J.B.Lubetsky, P.H.Liang, K.S.Anderson, E.Lolis. Crystallographic Studies of Phosphonate-Based Alpha-Reaction Transition-State Analogues Complexed to Tryptophan Synthase. Biochemistry V. 38 12665 1999.
ISSN: ISSN 0006-2960
PubMed: 10504236
DOI: 10.1021/BI9907734
Page generated: Sun Oct 6 17:59:47 2024

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