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Sodium in PDB 8xwc: Crystal Structure of Human 8-Oxoguanine Glycosylase K249H Mutant Bound to the Substrate 8-Oxoguanine Dna at pH 8.0 Under 277 K

Enzymatic activity of Crystal Structure of Human 8-Oxoguanine Glycosylase K249H Mutant Bound to the Substrate 8-Oxoguanine Dna at pH 8.0 Under 277 K

All present enzymatic activity of Crystal Structure of Human 8-Oxoguanine Glycosylase K249H Mutant Bound to the Substrate 8-Oxoguanine Dna at pH 8.0 Under 277 K:
4.2.99.18;

Protein crystallography data

The structure of Crystal Structure of Human 8-Oxoguanine Glycosylase K249H Mutant Bound to the Substrate 8-Oxoguanine Dna at pH 8.0 Under 277 K, PDB code: 8xwc was solved by M.Unno, M.Koga, N.Minowa, S.Komuro, Y.Tanaka, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.98 / 1.45
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 61.808, 69.544, 87.955, 90, 90, 90
R / Rfree (%) 15.4 / 17.9

Other elements in 8xwc:

The structure of Crystal Structure of Human 8-Oxoguanine Glycosylase K249H Mutant Bound to the Substrate 8-Oxoguanine Dna at pH 8.0 Under 277 K also contains other interesting chemical elements:

Magnesium (Mg) 1 atom

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure of Human 8-Oxoguanine Glycosylase K249H Mutant Bound to the Substrate 8-Oxoguanine Dna at pH 8.0 Under 277 K (pdb code 8xwc). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of Human 8-Oxoguanine Glycosylase K249H Mutant Bound to the Substrate 8-Oxoguanine Dna at pH 8.0 Under 277 K, PDB code: 8xwc:

Sodium binding site 1 out of 1 in 8xwc

Go back to Sodium Binding Sites List in 8xwc
Sodium binding site 1 out of 1 in the Crystal Structure of Human 8-Oxoguanine Glycosylase K249H Mutant Bound to the Substrate 8-Oxoguanine Dna at pH 8.0 Under 277 K


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of Human 8-Oxoguanine Glycosylase K249H Mutant Bound to the Substrate 8-Oxoguanine Dna at pH 8.0 Under 277 K within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na404

b:29.4
occ:1.00
OE1 A:GLN227 2.3 27.2 1.0
CB A:GLN227 3.3 14.6 1.0
CD A:GLN227 3.3 15.8 1.0
CA A:TRP224 3.4 10.2 1.0
O A:ALA223 3.7 12.2 1.0
N A:TRP224 3.7 10.1 1.0
C A:ALA223 3.8 11.0 1.0
CG A:GLN227 3.8 18.4 1.0
O A:HOH732 4.0 20.8 1.0
CB A:TRP224 4.2 10.4 1.0
CD1 A:TRP224 4.2 9.8 1.0
NE2 A:GLN227 4.4 22.5 1.0
C A:TRP224 4.5 11.3 1.0
O A:TRP224 4.6 10.4 1.0
CA A:GLN227 4.6 11.7 1.0
CB A:ALA223 4.6 14.4 1.0
O A:GLN219 4.6 12.7 1.0
CG A:TRP224 4.7 10.4 1.0
N A:GLN227 4.8 11.7 1.0
CA A:ALA223 4.9 10.6 1.0
O A:HOH651 5.0 18.0 1.0

Reference:

M.Unno, M.Morikawa, V.Sychovsky, M.Koga, N.Minowa, S.Komuro, M.Fukuta, F.Tshuyuguchi, R.Inamura, H.Mano, K.Nakashima, Y.Okamoto, T.Saito, Y.Hattori, Y.Tanaka. Active Residue Mutation of HOGG1 Provides A Novel Active Mutant with An Alternative Reaction Pathway To Be Published.
Page generated: Mon Aug 18 16:25:16 2025

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