Sodium in PDB 9eqh: WWP2 WW2-2,3-Linker-Hect (WWP2-Lh)

All present enzymatic activity of WWP2 WW2-2,3-Linker-Hect (WWP2-Lh):
2.3.2.26;

The structure of WWP2 WW2-2,3-Linker-Hect (WWP2-Lh), PDB code: 9eqh was solved by A.P.Dudey, A.M.Hemmings, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	70.08 / 2.05
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	44.009, 90.27, 111.177, 90, 90, 90
R / Rfree (%)	21.3 / 27.5

The binding sites of Sodium atom in the WWP2 WW2-2,3-Linker-Hect (WWP2-Lh) (pdb code 9eqh). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the WWP2 WW2-2,3-Linker-Hect (WWP2-Lh), PDB code: 9eqh:

Sodium binding site 1 out of 1 in the WWP2 WW2-2,3-Linker-Hect (WWP2-Lh)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of WWP2 WW2-2,3-Linker-Hect (WWP2-Lh) within 5.0Å range: probe atom residue distance (Å) B Occ A:Na903 b:39.0 occ:1.00 H A:ARG521 2.5 27.4 1.0 O A:ARG549 2.7 26.6 1.0 OE2 A:GLU551 2.8 34.5 1.0 HA A:SER520 3.1 26.0 1.0 N A:ARG521 3.1 27.2 1.0 HB2 A:ARG521 3.1 29.0 1.0 HE3 A:MET548 3.2 41.1 1.0 HB3 A:ARG521 3.2 29.0 1.0 HB3 A:MET548 3.2 35.2 1.0 HG3 A:GLU551 3.5 35.0 1.0 HB3 A:ARG549 3.5 45.4 1.0 CB A:ARG521 3.5 27.4 1.0 HE2 A:MET548 3.6 41.1 1.0 N A:ARG549 3.7 33.7 1.0 CD A:GLU551 3.7 35.3 1.0 H A:ARG549 3.7 35.4 1.0 C A:ARG549 3.7 39.6 1.0 CA A:ARG521 3.8 29.6 1.0 CA A:SER520 3.9 25.1 1.0 CE A:MET548 3.9 39.3 1.0 C A:MET548 3.9 35.8 1.0 C A:SER520 3.9 25.6 1.0 OG A:SER520 4.0 36.3 1.0 HA A:MET548 4.1 35.2 1.0 CG A:GLU551 4.1 36.0 1.0 CA A:ARG549 4.1 38.7 1.0 CB A:MET548 4.1 33.5 1.0 HA A:ARG521 4.2 29.7 1.0 CB A:ARG549 4.2 45.0 1.0 CA A:MET548 4.3 35.5 1.0 HE A:ARG521 4.3 33.7 1.0 O A:VAL519 4.3 30.6 1.0 O A:MET548 4.4 31.9 1.0 HE1 A:MET548 4.4 41.0 1.0 CB A:SER520 4.6 30.6 1.0 OE1 A:GLU551 4.6 29.4 1.0 HB2 A:MET548 4.6 35.2 1.0 HE21 A:GLN522 4.7 23.4 1.0 HG A:SER520 4.7 36.2 0.0 HG2 A:GLU551 4.8 35.0 1.0 HB2 A:GLU551 4.8 34.0 1.0 HB2 A:ARG549 4.8 45.3 1.0 H A:GLU551 4.8 34.8 1.0 NE A:ARG521 4.8 33.0 1.0 CG A:ARG521 4.9 31.9 1.0 H A:GLN522 4.9 32.3 1.0 N A:SER520 4.9 23.8 1.0 HB3 A:SER520 5.0 30.4 1.0 N A:GLY550 5.0 32.3 1.0 HD2 A:ARG521 5.0 31.9 1.0 HG2 A:ARG549 5.0 51.6 1.0

A.P.Dudey, J.M.Rigby, G.R.Hughes, G.R.Stephenson, T.E.Storr, A.Chantry, A.M.Hemmings. Expanding the Inhibitor Space of the WWP1 and WWP2 Hect E3 Ligases To Be Published.