Sodium in PDB 8zyj: Cryo-Em Structure of Human Testis-Specific Na+,K+-Atpase ALPHA4 in Ouabain-Bound Form

All present enzymatic activity of Cryo-Em Structure of Human Testis-Specific Na+,K+-Atpase ALPHA4 in Ouabain-Bound Form:
7.2.2.13;

The structure of Cryo-Em Structure of Human Testis-Specific Na+,K+-Atpase ALPHA4 in Ouabain-Bound Form also contains other interesting chemical elements:

Fluorine	(F)	3 atoms
Magnesium	(Mg)	1 atom

The binding sites of Sodium atom in the Cryo-Em Structure of Human Testis-Specific Na+,K+-Atpase ALPHA4 in Ouabain-Bound Form (pdb code 8zyj). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Cryo-Em Structure of Human Testis-Specific Na+,K+-Atpase ALPHA4 in Ouabain-Bound Form, PDB code: 8zyj:

Sodium binding site 1 out of 1 in the Cryo-Em Structure of Human Testis-Specific Na+,K+-Atpase ALPHA4 in Ouabain-Bound Form


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Cryo-Em Structure of Human Testis-Specific Na+,K+-Atpase ALPHA4 in Ouabain-Bound Form within 5.0Å range: probe atom residue distance (Å) B Occ A:Na1102 b:54.3 occ:1.00 O A:ALA734 2.4 47.2 1.0 OD2 A:ASP753 2.8 48.8 1.0 O A:LYS732 3.0 43.7 1.0 O A:LEU731 3.1 37.4 1.0 C A:ALA734 3.4 37.6 1.0 C A:LYS732 3.7 38.3 1.0 CG A:ASP753 3.8 47.8 1.0 N A:GLY737 3.9 32.1 1.0 N A:ALA734 4.0 33.2 1.0 OD1 A:ASP753 4.0 60.5 1.0 CA A:LYS732 4.1 38.9 1.0 O A:ASP735 4.1 39.6 1.0 CA A:ALA734 4.2 32.5 1.0 C A:ASP735 4.2 27.1 1.0 C A:LEU731 4.2 24.4 1.0 N A:ILE736 4.4 30.4 1.0 C A:ILE736 4.4 28.1 1.0 CB A:ALA734 4.5 28.1 1.0 N A:ASP735 4.5 38.7 1.0 C A:LYS733 4.5 31.1 1.0 CA A:ILE736 4.5 27.9 1.0 CA A:GLY737 4.6 23.4 1.0 N A:LYS733 4.6 32.7 1.0 CA A:ASP735 4.6 29.0 1.0 N A:LYS732 4.7 33.9 1.0 O A:ALA751 4.7 42.7 1.0 O A:LYS733 4.9 38.4 1.0

K.Abe, J.Mcdermott, H.V.Madapally, P.Marimuthu, C.C.Gopalasingam, C.Gerle, H.Shigematsu, H.Khandelia, G.Blanco. Molecular Structure of the Na+,K+-Atpase ALPHA4BETA1 Isoform in Its Ouabain-Bound Conformation. Int J Mol Sci V. 25 2024.
ISSN: ESSN 1422-0067
DOI: 10.3390/IJMS252212397