Sodium in PDB 8wtw: Cryo-Em Structure of Noradrenaline Transporter in Complex with A X- Mrla Analogue

The structure of Cryo-Em Structure of Noradrenaline Transporter in Complex with A X- Mrla Analogue also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Sodium atom in the Cryo-Em Structure of Noradrenaline Transporter in Complex with A X- Mrla Analogue (pdb code 8wtw). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Cryo-Em Structure of Noradrenaline Transporter in Complex with A X- Mrla Analogue, PDB code: 8wtw:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Cryo-Em Structure of Noradrenaline Transporter in Complex with A X- Mrla Analogue


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Cryo-Em Structure of Noradrenaline Transporter in Complex with A X- Mrla Analogue within 5.0Å range: probe atom residue distance (Å) B Occ A:Na702 b:53.9 occ:1.00 O A:ALA73 2.3 40.7 1.0 OD1 A:ASN78 2.3 55.2 1.0 O A:SER318 2.6 56.3 1.0 OG A:SER318 2.7 57.4 1.0 OD1 A:ASN350 2.9 50.5 1.0 CG A:ASN78 3.0 51.2 1.0 ND2 A:ASN78 3.1 49.2 1.0 C A:ALA73 3.5 43.3 1.0 C A:SER318 3.5 46.8 1.0 OD1 A:ASP75 3.6 56.1 1.0 CA A:SER318 3.8 44.2 1.0 CB A:SER318 3.8 41.1 1.0 CG A:ASN350 4.0 48.6 1.0 CA A:VAL74 4.1 37.0 1.0 N A:VAL74 4.3 38.8 1.0 N A:ASP75 4.3 38.9 1.0 ND2 A:ASN350 4.5 45.1 1.0 CB A:ASN78 4.5 45.2 1.0 CA A:ALA73 4.5 38.4 1.0 C A:VAL74 4.7 37.7 1.0 CG A:ASP75 4.7 57.2 1.0 N A:LEU319 4.8 41.4 1.0 N A:ASN78 4.8 50.8 1.0 CL A:CL701 5.0 71.0 1.0

Sodium binding site 2 out of 2 in the Cryo-Em Structure of Noradrenaline Transporter in Complex with A X- Mrla Analogue


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Cryo-Em Structure of Noradrenaline Transporter in Complex with A X- Mrla Analogue within 5.0Å range: probe atom residue distance (Å) B Occ A:Na703 b:66.5 occ:1.00 O A:GLY71 2.3 32.5 1.0 O A:VAL74 2.3 37.8 1.0 O A:LEU415 2.4 49.0 1.0 OG A:SER419 2.6 42.9 1.0 N A:SER419 3.4 37.5 1.0 CB A:ASP418 3.4 45.2 1.0 C A:VAL74 3.5 37.7 1.0 C A:GLY71 3.5 30.3 1.0 C A:LEU415 3.6 37.5 1.0 CB A:SER419 3.8 40.1 1.0 CB A:ASP75 4.0 45.1 1.0 C A:ASP418 4.0 41.3 1.0 CA A:ASP75 4.0 29.8 1.0 CA A:ASP418 4.1 32.9 1.0 CA A:SER419 4.1 34.7 1.0 N A:ASP75 4.2 38.9 1.0 N A:ASP418 4.2 40.0 1.0 OD2 A:ASP418 4.3 42.5 1.0 CA A:LEU415 4.3 29.8 1.0 O A:PHE72 4.3 48.4 1.0 CA A:PHE72 4.4 37.2 1.0 CG A:ASP418 4.4 47.9 1.0 N A:PHE72 4.4 33.4 1.0 CA A:GLY71 4.4 34.6 1.0 C A:PHE72 4.4 44.7 1.0 N A:GLY416 4.6 37.1 1.0 N A:VAL74 4.6 38.8 1.0 CA A:VAL74 4.6 37.0 1.0 O A:ALA414 4.6 52.0 1.0 CA A:GLY416 4.8 29.9 1.0 C A:GLY416 4.9 34.8 1.0 O A:ASP418 4.9 45.6 1.0

T.Hu, Z.Yu, J.Zhao, Y.Meng, K.Salomon, Q.Bai, Y.Wei, J.Zhang, S.Xu, Q.Dai, R.Yu, B.Yang, C.J.Loland, Y.Zhao. Transport and Inhibition Mechanisms of the Human Noradrenaline Transporter. Nature 2024.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-024-07638-Z