Sodium in PDB 8w6o: NAS1 in in/in State

The binding sites of Sodium atom in the NAS1 in in/in State (pdb code 8w6o). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 4 binding sites of Sodium where determined in the NAS1 in in/in State, PDB code: 8w6o:
Jump to Sodium binding site number: 1; 2; 3; 4;

Sodium binding site 1 out of 4 in the NAS1 in in/in State


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of NAS1 in in/in State within 5.0Å range: probe atom residue distance (Å) B Occ A:Na701 b:15.4 occ:1.00 O A:LEU138 2.5 15.8 1.0 O A:SER135 2.5 13.2 1.0 OD1 A:ASN140 2.5 16.5 1.0 O A:GLY258 2.5 18.3 1.0 N A:ASN140 3.2 16.5 1.0 CA A:SER139 3.3 16.5 1.0 C A:SER139 3.3 16.5 1.0 C A:LEU138 3.4 15.8 1.0 C A:SER135 3.4 13.2 1.0 CB A:SER135 3.6 13.2 1.0 CG A:ASN140 3.6 16.5 1.0 CA A:SER135 3.6 13.2 1.0 C A:GLY258 3.7 18.3 1.0 N A:SER139 3.7 16.5 1.0 O A:SER139 4.0 16.5 1.0 CA A:ASN140 4.0 16.5 1.0 CA A:GLY252 4.1 15.5 1.0 CA A:GLY258 4.3 18.3 1.0 CB A:ASN140 4.4 16.5 1.0 ND2 A:ASN140 4.5 16.5 1.0 CB A:SER139 4.6 16.5 1.0 N A:MET136 4.6 15.0 1.0 CA A:LEU138 4.7 15.8 1.0 N A:LEU138 4.7 15.8 1.0 N A:THR259 4.8 19.1 1.0 OG A:SER135 4.8 13.2 1.0 N A:GLY252 4.9 15.5 1.0

Sodium binding site 2 out of 4 in the NAS1 in in/in State


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of NAS1 in in/in State within 5.0Å range: probe atom residue distance (Å) B Occ A:Na702 b:20.4 occ:1.00 O A:THR485 2.5 19.1 1.0 OD1 A:ASN490 2.5 19.8 1.0 O A:ALA488 2.6 21.1 1.0 O A:ALA532 2.7 26.1 1.0 C A:ALA532 3.0 26.1 1.0 CB A:ALA532 3.0 26.1 1.0 CA A:ALA532 3.1 26.1 1.0 OG1 A:THR485 3.4 19.1 1.0 C A:ALA488 3.6 21.1 1.0 CG A:ASN490 3.6 19.8 1.0 C A:THR485 3.7 19.1 1.0 N A:ASN490 3.8 19.8 1.0 N A:ASN533 3.9 23.6 1.0 C A:SER489 3.9 20.5 1.0 CB A:ALA526 3.9 18.8 1.0 CA A:SER489 3.9 20.5 1.0 N A:SER489 4.2 20.5 1.0 CA A:THR485 4.3 19.1 1.0 CB A:THR485 4.4 19.1 1.0 CA A:ASN490 4.4 19.8 1.0 ND2 A:ASN490 4.5 19.8 1.0 O A:SER489 4.5 20.5 1.0 CB A:ASN490 4.5 19.8 1.0 N A:ALA532 4.6 26.1 1.0 CA A:ASN533 4.6 23.6 1.0 CB A:ASN533 4.7 23.6 1.0 N A:GLU486 4.7 21.3 1.0 N A:ALA488 4.8 21.1 1.0 CA A:ALA488 4.8 21.1 1.0 CG2 A:THR485 5.0 19.1 1.0 CA A:GLU486 5.0 21.3 1.0 C A:GLU486 5.0 21.3 1.0

Sodium binding site 3 out of 4 in the NAS1 in in/in State


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of NAS1 in in/in State within 5.0Å range: probe atom residue distance (Å) B Occ B:Na701 b:16.1 occ:1.00 O B:LEU138 2.5 15.1 1.0 O B:SER135 2.5 14.1 1.0 OD1 B:ASN140 2.5 16.1 1.0 O B:GLY258 2.5 18.9 1.0 N B:ASN140 3.2 16.1 1.0 C B:SER139 3.2 16.2 1.0 CA B:SER139 3.3 16.2 1.0 C B:SER135 3.4 14.1 1.0 C B:LEU138 3.4 15.1 1.0 CG B:ASN140 3.5 16.1 1.0 CB B:SER135 3.6 14.1 1.0 C B:GLY258 3.7 18.9 1.0 CA B:SER135 3.7 14.1 1.0 N B:SER139 3.8 16.2 1.0 O B:SER139 3.9 16.2 1.0 CA B:ASN140 4.0 16.1 1.0 CA B:GLY252 4.1 15.6 1.0 CA B:GLY258 4.3 18.9 1.0 CB B:ASN140 4.4 16.1 1.0 ND2 B:ASN140 4.4 16.1 1.0 CB B:SER139 4.6 16.2 1.0 N B:MET136 4.6 14.3 1.0 CA B:LEU138 4.7 15.1 1.0 N B:THR259 4.8 19.2 1.0 N B:LEU138 4.8 15.1 1.0 OG B:SER135 4.9 14.1 1.0 N B:GLY252 4.9 15.6 1.0

Sodium binding site 4 out of 4 in the NAS1 in in/in State


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 4 of NAS1 in in/in State within 5.0Å range: probe atom residue distance (Å) B Occ B:Na702 b:20.3 occ:1.00 O B:THR485 2.5 18.4 1.0 OD1 B:ASN490 2.5 19.9 1.0 O B:ALA488 2.6 20.5 1.0 O B:ALA532 2.8 26.0 1.0 CB B:ALA532 3.0 26.0 1.0 C B:ALA532 3.0 26.0 1.0 CA B:ALA532 3.1 26.0 1.0 OG1 B:THR485 3.4 18.4 1.0 C B:THR485 3.7 18.4 1.0 CG B:ASN490 3.7 19.9 1.0 C B:ALA488 3.7 20.5 1.0 N B:ASN490 3.7 19.9 1.0 C B:SER489 3.9 20.7 1.0 CA B:SER489 3.9 20.7 1.0 N B:ASN533 3.9 23.6 1.0 CB B:ALA526 3.9 18.0 1.0 N B:SER489 4.2 20.7 1.0 CA B:THR485 4.3 18.4 1.0 CB B:THR485 4.4 18.4 1.0 CA B:ASN490 4.4 19.9 1.0 O B:SER489 4.5 20.7 1.0 ND2 B:ASN490 4.5 19.9 1.0 CB B:ASN490 4.5 19.9 1.0 N B:ALA532 4.6 26.0 1.0 CA B:ASN533 4.7 23.6 1.0 N B:GLU486 4.7 20.8 1.0 CB B:ASN533 4.8 23.6 1.0 N B:ALA488 4.9 20.5 1.0 CA B:ALA488 4.9 20.5 1.0 CA B:GLU486 4.9 20.8 1.0 C B:GLU486 5.0 20.8 1.0

X.Chi, Y.Chen, Y.Li, L.Dai, Y.Zhang, Y.Shen, Y.Chen, T.Shi, H.Yang, Z.Wang, R.Yan. Cryo-Em Structures of the Human NAS1 and NADC1 Transporters Revealed the Elevator Transport and Allosteric Regulation Mechanism. Sci Adv V. 10 L3685 2024.
ISSN: ESSN 2375-2548
PubMed: 38552027
DOI: 10.1126/SCIADV.ADL3685