Sodium in PDB 8w43: X-Ray Crystal Structure of V30M-Ttr in Complex with Piceatannol

The structure of X-Ray Crystal Structure of V30M-Ttr in Complex with Piceatannol, PDB code: 8w43 was solved by T.Yokoyama, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.09 / 1.30
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	43.221, 84.189, 62.954, 90, 90, 90
R / Rfree (%)	15.6 / 18.1

The binding sites of Sodium atom in the X-Ray Crystal Structure of V30M-Ttr in Complex with Piceatannol (pdb code 8w43). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the X-Ray Crystal Structure of V30M-Ttr in Complex with Piceatannol, PDB code: 8w43:

Sodium binding site 1 out of 1 in the X-Ray Crystal Structure of V30M-Ttr in Complex with Piceatannol


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of X-Ray Crystal Structure of V30M-Ttr in Complex with Piceatannol within 5.0Å range: probe atom residue distance (Å) B Occ A:Na202 b:30.8 occ:1.00 O A:ASP99 2.2 29.1 1.0 O A:HOH357 2.4 32.4 1.0 O A:HOH373 2.5 48.8 1.0 O A:HOH388 2.7 45.8 1.0 C A:ASP99 3.5 28.9 1.0 OE1 A:GLU66 4.3 31.4 1.0 CA A:ASP99 4.3 28.4 1.0 N A:SER100 4.4 30.5 1.0 CA A:SER100 4.5 33.9 1.0 CB A:ASP99 4.5 33.6 1.0 O A:HOH384 4.5 53.8 1.0 CD A:GLU66 4.7 30.8 1.0 OE2 A:GLU66 4.8 32.7 1.0

T.Yokoyama, K.Kusaka, M.Mizuguchi, Y.Nabeshima, S.Fujiwara. Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights Into the Interactions Between Resveratrol Derivatives and Transthyretin. J.Med.Chem. 2023.
ISSN: ISSN 0022-2623
PubMed: 37910439
DOI: 10.1021/ACS.JMEDCHEM.3C01698