Sodium in PDB 8tra: Cryo-Em Structure of the Rat P2X7 Receptor in Complex with the Allosteric Antagonist GSK1482160

The structure of Cryo-Em Structure of the Rat P2X7 Receptor in Complex with the Allosteric Antagonist GSK1482160 also contains other interesting chemical elements:

Chlorine	(Cl)	3 atoms
Fluorine	(F)	9 atoms
Zinc	(Zn)	6 atoms

The binding sites of Sodium atom in the Cryo-Em Structure of the Rat P2X7 Receptor in Complex with the Allosteric Antagonist GSK1482160 (pdb code 8tra). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Cryo-Em Structure of the Rat P2X7 Receptor in Complex with the Allosteric Antagonist GSK1482160, PDB code: 8tra:

Sodium binding site 1 out of 1 in the Cryo-Em Structure of the Rat P2X7 Receptor in Complex with the Allosteric Antagonist GSK1482160


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Cryo-Em Structure of the Rat P2X7 Receptor in Complex with the Allosteric Antagonist GSK1482160 within 5.0Å range: probe atom residue distance (Å) B Occ A:Na612 b:30.0 occ:1.00 HG C:SER342 1.8 12.8 1.0 HG A:SER342 1.9 12.8 1.0 HG B:SER342 1.9 12.8 1.0 OG C:SER342 1.9 12.8 1.0 OG A:SER342 1.9 12.8 1.0 OG B:SER342 1.9 12.8 1.0 O C:HOH701 2.9 9.8 1.0 O B:HOH701 2.9 30.0 1.0 O A:HOH701 2.9 30.0 1.0 CB C:SER342 3.1 12.8 1.0 CB A:SER342 3.2 12.8 1.0 CB B:SER342 3.2 12.8 1.0 HB2 C:SER342 3.3 12.8 1.0 HB2 A:SER342 3.3 12.8 1.0 HB2 B:SER342 3.3 12.8 1.0 H C:SER342 3.6 12.8 1.0 H B:SER342 3.7 12.8 1.0 H A:SER342 3.7 12.8 1.0 HB3 C:SER342 3.8 12.8 1.0 HB3 A:SER342 3.8 12.8 1.0 HB3 B:SER342 3.8 12.8 1.0 CA C:SER342 4.0 12.8 1.0 HA C:SER342 4.0 12.8 1.0 CA B:SER342 4.0 12.8 1.0 CA A:SER342 4.0 12.8 1.0 HA B:SER342 4.0 12.8 1.0 HA A:SER342 4.0 12.8 1.0 N C:SER342 4.0 12.8 1.0 N B:SER342 4.1 12.8 1.0 N A:SER342 4.1 12.8 1.0 O C:HOH746 4.1 18.6 1.0 O B:HOH746 4.1 30.0 1.0 O A:HOH739 4.1 30.0 1.0 O B:GLY338 4.3 11.8 1.0 O A:GLY338 4.3 11.8 1.0 O C:GLY338 4.3 11.8 1.0 HB2 B:LEU341 4.6 13.0 1.0 HB2 C:LEU341 4.6 13.0 1.0 HB2 A:LEU341 4.7 13.0 1.0 HB3 B:LEU341 5.0 13.0 1.0 HB3 C:LEU341 5.0 13.0 1.0 HB3 A:LEU341 5.0 13.0 1.0

A.C.Oken, I.A.Ditter, N.E.Lisi, I.Krishnamurthy, M.H.Godsey, S.E.Mansoor. P2X 7 Receptors Exhibit at Least Three Modes of Allosteric Antagonism. Sci Adv V. 10 O5084 2024.
ISSN: ESSN 2375-2548
PubMed: 39365862
DOI: 10.1126/SCIADV.ADO5084