Sodium in PDB 8tr8: Cryo-Em Structure of the Rat P2X7 Receptor in Complex with the Allosteric Antagonist AZD9056

The structure of Cryo-Em Structure of the Rat P2X7 Receptor in Complex with the Allosteric Antagonist AZD9056 also contains other interesting chemical elements:

Zinc	(Zn)	6 atoms
Chlorine	(Cl)	3 atoms

The binding sites of Sodium atom in the Cryo-Em Structure of the Rat P2X7 Receptor in Complex with the Allosteric Antagonist AZD9056 (pdb code 8tr8). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Cryo-Em Structure of the Rat P2X7 Receptor in Complex with the Allosteric Antagonist AZD9056, PDB code: 8tr8:

Sodium binding site 1 out of 1 in the Cryo-Em Structure of the Rat P2X7 Receptor in Complex with the Allosteric Antagonist AZD9056


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Cryo-Em Structure of the Rat P2X7 Receptor in Complex with the Allosteric Antagonist AZD9056 within 5.0Å range: probe atom residue distance (Å) B Occ A:Na612 b:14.2 occ:1.00 HG C:SER342 2.3 16.1 1.0 HG A:SER342 2.3 16.1 1.0 OG C:SER342 2.3 16.1 1.0 HG B:SER342 2.3 16.1 1.0 OG A:SER342 2.4 16.1 1.0 OG B:SER342 2.5 16.1 1.0 O B:HOH709 2.7 13.3 1.0 O A:HOH709 2.8 13.4 1.0 O C:HOH711 2.8 13.3 1.0 HB2 C:SER342 3.2 16.1 1.0 HB2 A:SER342 3.3 16.1 1.0 CB C:SER342 3.3 16.1 1.0 CB A:SER342 3.4 16.1 1.0 HB2 B:SER342 3.4 16.1 1.0 H C:SER342 3.4 16.1 1.0 H A:SER342 3.5 16.1 1.0 CB B:SER342 3.5 16.1 1.0 H B:SER342 3.6 16.1 1.0 O C:GLY338 3.9 15.6 1.0 O A:GLY338 3.9 15.6 1.0 N C:SER342 4.0 16.1 1.0 N A:SER342 4.0 16.1 1.0 O B:GLY338 4.0 15.6 1.0 HB3 C:SER342 4.1 16.1 1.0 HB3 A:SER342 4.1 16.1 1.0 CA C:SER342 4.1 16.1 1.0 CA A:SER342 4.2 16.1 1.0 HB3 B:SER342 4.2 16.1 1.0 N B:SER342 4.2 16.1 1.0 HA C:SER342 4.2 16.1 1.0 O B:HOH735 4.3 19.6 1.0 HA A:SER342 4.3 16.1 1.0 HB2 C:LEU341 4.3 16.2 1.0 HB2 A:LEU341 4.3 16.2 1.0 O C:HOH721 4.3 18.2 1.0 O A:HOH724 4.3 14.9 1.0 CA B:SER342 4.3 16.1 1.0 HA B:SER342 4.5 16.1 1.0 HB2 B:LEU341 4.5 16.2 1.0 HB3 C:LEU341 5.0 16.2 1.0 HB3 A:LEU341 5.0 16.2 1.0 C C:LEU341 5.0 16.2 1.0

A.C.Oken, I.A.Ditter, N.E.Lisi, I.Krishnamurthy, M.H.Godsey, S.E.Mansoor. P2X 7 Receptors Exhibit at Least Three Modes of Allosteric Antagonism. Sci Adv V. 10 O5084 2024.
ISSN: ESSN 2375-2548
PubMed: 39365862
DOI: 10.1126/SCIADV.ADO5084