Sodium in PDB 8ta1: Crystal Structure of Dihydrofolate Reductase (Dhfr) From Mycobacterium Ulcerans AGY99 in Complex with Nadp and Inhibitor MAM907

Enzymatic activity of Crystal Structure of Dihydrofolate Reductase (Dhfr) From Mycobacterium Ulcerans AGY99 in Complex with Nadp and Inhibitor MAM907

All present enzymatic activity of Crystal Structure of Dihydrofolate Reductase (Dhfr) From Mycobacterium Ulcerans AGY99 in Complex with Nadp and Inhibitor MAM907:
1.5.1.3;

Protein crystallography data

The structure of Crystal Structure of Dihydrofolate Reductase (Dhfr) From Mycobacterium Ulcerans AGY99 in Complex with Nadp and Inhibitor MAM907, PDB code: 8ta1 was solved by Seattle Structural Genomics Center For Infectious Disease, Seattlestructural Genomics Center For Infectious Disease (Ssgcid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 22.27 / 1.50
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 28.722, 66.265, 44.138, 90, 92.21, 90
R / Rfree (%) 14.7 / 16.7

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure of Dihydrofolate Reductase (Dhfr) From Mycobacterium Ulcerans AGY99 in Complex with Nadp and Inhibitor MAM907 (pdb code 8ta1). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of Dihydrofolate Reductase (Dhfr) From Mycobacterium Ulcerans AGY99 in Complex with Nadp and Inhibitor MAM907, PDB code: 8ta1:

Sodium binding site 1 out of 1 in 8ta1

Go back to Sodium Binding Sites List in 8ta1
Sodium binding site 1 out of 1 in the Crystal Structure of Dihydrofolate Reductase (Dhfr) From Mycobacterium Ulcerans AGY99 in Complex with Nadp and Inhibitor MAM907


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of Dihydrofolate Reductase (Dhfr) From Mycobacterium Ulcerans AGY99 in Complex with Nadp and Inhibitor MAM907 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na201

b:35.4
occ:1.00
 O A:HOH466 2.0 20.6 1.0
N A:GLY61 2.8 8.3 1.0
O A:HOH507 3.0 25.1 1.0
CA A:PRO60 3.5 8.9 1.0
C A:PRO60 3.7 8.9 1.0
CA A:GLY61 3.8 9.4 1.0
O A:HOH434 3.9 22.4 1.0
O A:LEU59 4.1 8.6 1.0
N A:ARG62 4.2 9.9 1.0
O A:ARG62 4.3 8.0 1.0
CB A:PRO60 4.4 10.1 1.0
C A:GLY61 4.4 9.3 1.0
N A:PRO60 4.6 7.4 1.0
C A:LEU59 4.8 6.5 1.0
O A:PRO60 4.8 8.9 1.0

Reference:

E.L.Woodward, S.Lovell, M.R.Mian, S.Seibold. Crystal Structure of Dihydrofolate Reductase (Dhfr) From Mycobacterium Ulcerans AGY99 in Complex with Nadp and Inhibitor MAM907 To Be Published.
Page generated: Wed Oct 9 13:39:42 2024

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